Zhejiang University

Nanoporous titanium implant functionalized with sustained strontium release orchestrates immune microenvironment for enhanced osseointegration

Objectives Insufficient osseointegration remains a major limitation of dental and orthopedic implants. This study aimed to develop a strontium-releasing nanoporous titanium surface (TDS) with improved interfacial stability and immunomodulatory capacity to promote implant osseoint...

Localized hotspot mitigation using a hybrid microchannel heat sink with alternating-orientation arched-bridge pin-fins

Localized hotspots induced by non-uniform heat generation in AI accelerators and data-center processors necessitate microchannel heat sinks that can enhance local heat removal and improve substrate temperature uniformity. In this context, hybrid microchannel heat sink with altern...

Rapid versus slow puncture in endoscopic ultrasound-guided liver biopsy: a multicenter randomized crossover trial

Abstract Endoscopic ultrasound-guided liver biopsy (EUS-LB) is increasingly used for hepatic histologic assessment; however, optimal technical approaches remain undefined. This prospective, multicenter clinical study aimed to compare tissue acquisition and safety between the rapi...

Digitally Mediated Heritage Tourism for Sustainable Heritage Management: Evidence from the Liangzhu Heritage Site

How heritage tourism scenes evolve alongside digital mediation and how different forms of mediation are represented in visitor accounts remain insufficiently understood. This study examines the Liangzhu heritage site, centred on the Archaeological Ruins of Liangzhu City, using 71...

Nuclear BbAtg8 interacts with BbMac1 as a transcriptional modulator to sustain nuclear copper homeostasis during conidial germination

Pathogenic fungi endure host impose copper starvation by tightly coordinating trace metal homeostasis. However, how pathogens synchronize endogenous metal recycling with exogenous copper uptake to promote infection remains enigmatic. Using the entomopathogenic fungus Beauveria ba...

Tough Hydrogels for Remodeling Ruptured Tendons

Abstract Hydrogels have shown broad application potential due to their high water content and excellent interfacial adaptability, however, conventional biocompatible hydrogels often struggle to simultaneously achieve high strength, high toughness, and favorable biocompatibility,...

Next-generation natural killer cell therapy: bench to bedside and beyond

Natural killer (NK) cells have emerged as central players in cancer immunotherapy, progressing from basic discovery to clinically validated platforms over five decades. This review synthesizes the evolving understanding of NK cell biology, including subset heterogeneity, epigenet...

Phase-Dependent Spectral Induced Polarization Signatures During DNAPL Transport in Porous Media

Dense non-aqueous phase liquids (DNAPLs) pose persistent challenges for subsurface characterization because their migration, retention, and phase partitioning are difficult to resolve using conventional monitoring approaches. Spectral induced polarization (SIP) provides a non-inv...

Thermal plume intensification and double-diffusive transport in sawtooth-finned non-Newtonian enclosures with dual-ANN prediction

Advanced thermal engineering increasingly demands compact geometries that intensify heat and mass transport for energy storage, electronic cooling, and high-performance heat exchangers. This study introduces a centrally heated and concentrated triangular sawtooth fin within a non...

Individual and Combined Impacts of Boreal Summer Intraseasonal Oscillation and ENSO on Tropical Western North Pacific Synoptic‐Scale Disturbance Intensity

Abstract Synoptic‐scale disturbances (SSDs) over tropical western North Pacific (TWNP) are subjected to impacts of boreal summer intraseasonal oscillation (BSISO) and El Niño–Southern Oscillation (ENSO). This study investigates individual and combined impacts of BSISO and ENSO on...

Documented Governance Configurations for Proximity-Based Public Cultural Services in Zhejiang, China

Proximity policies specify where services should be reachable, but documented service design does not establish sustained operation. This study compares the policy and governance configurations presented for public cultural services in Jiaxing and Lishui, Zhejiang, China. Operati...

Early low-molecular-weight heparin versus early aspirin after off-pump coronary artery bypass: a retrospective propensity score-matched exploratory study

The optimal early antithrombotic strategy after off‑pump coronary artery bypass grafting (OPCAB) remains controversial. This single‑center retrospective propensity‑score matched study compared antithrombotic therapies initiated at postoperative 6 h. Clinical data were retrieved f...

Shifting cognitive structures in human-AI collaborative learning design

This study examines collaborative learning design with a generative artificial intelligence (GenAI) co-pilot among in-service university English teachers in China. In a between-subjects experiment ( N = 60), epistemic network analysis (ENA) was used to model the situated discours...

Metropolis-scale resilient and trustworthy traffic flow inference using multi-source data

Inferring network-wide traffic states from sparse observations with high accuracy and trustworthy uncertainty quantification is essential for intelligent transportation systems, yet it remains challenging due to the underdetermined nature of the problem, multifaceted disturbances...

Modeling of vibrational non-equilibrium in detonation with global kinetics

One-, two-, and three-step global kinetic models that include thermal non-equilibrium were developed for detonation simulations using the open-source software Cantera and the Shock and Detonation Toolbox (SDToolbox). The rate coefficients and thermodynamic parameters of these mod...

Interpolating chromatic and homomorphism thresholds

The problem of chromatic thresholds seeks minimum degree conditions that ensure that dense H -free graphs have a bounded chromatic number, or equivalently a bounded size homomorphic image. The strengthened homomorphism thresholds problem further requires that the homomorphic imag...

A Dual-Functional Hydrogel Coating for Expanded Polytetrafluoroethylene Endografts with Antibacterial and Interface-Sealing Functions

Abstract Although expanded polytetrafluoroethylene (ePTFE) endografts provide excellent mechanical exclusion of aneurysm blood flow, they remain biologically inert and lack surface functions that actively prevent bacterial colonization or promote favorable graft–vessel interface...

Healthy lifestyle as a protective factor against the risk of gastroesophageal reflux disease: Prospective population cohort analysis

Background Lifestyle modifications are recommended by American Gastroenterological Association (AGA) for managing gastroesophageal reflux disease (GERD), a significant health issue; but evidence is scarce. This study aims to investigate the longitudinal association between health...

Proteomics insight into phosphate limitation response in Burkholderia phytopathogens

Inorganic phosphate (Pi) limitation is a pervasive environmental constraint that shapes microbial behaviour in soil and plant-associated niches. To determine how Pi scarcity influences the pathogenic potential of rice-infecting Burkholderia species, we performed comparative prote...

A pair of chitosan receptors confer broad-spectrum fungal resistance

Chitosan, a major fungal cell wall component, activates plant immunity, yet the underlying perception mechanism remains unknown. In this study, we identified OsFID1, an apoplast-localized DUF26 domain protein, as a chitosan-binding receptor essential for chitosan-triggered immuni...