Zhejiang University

Autophagy-regulating bioactive nanoparticle alleviates MASH via gut–liver axis-mediated mitochondria/cAMP/GLP1 pathway

Chronic exposure of the liver to diverse insults can lead to metabolic dysfunction-associated steatohepatitis (MASH), a complex metabolic disorder characterized by hepatic steatosis and inflammation, often accompanied by progressive fibrosis, intestinal barrier dysfunction, and i...

Risk-taking in automated tasks: The role of sense of agency

Automation improves task performance, yet it also systematically alters how operators take risks. Which characteristics of automation drive this change, and through what psychological mechanism, remains unresolved: the sense of agency has often been implicated but never quantitat...

Functional mapping of IFITM3 resolves its antiviral core and deciphers human influenza susceptibility

Genetic variation in interferon-induced transmembrane protein 3 (IFITM3) contributes to inter-individual differences in influenza outcome, yet a comprehensive functional map of IFITM3 variation remains unavailable. Here we show a high-resolution functional atlas of 2,898 IFITM3 v...

From graph Laplacian to ring polymer dynamics: part I

Abstract A graph-theoretic formulation of overdamped Langevin dynamics and constitutive equations for ring polymers is developed. The polymer molecule is represented as a bead–spring network whose connectivity is described by a graph Laplacian. Starting from overdamped stochastic...

Associations of C-reactive protein-triglyceride-glucose index and cholesterol-high-density lipoprotein-glucose index with heart disease risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: a cohort study from CHARLS

Abstract Background Although the C-reactive protein-triglyceride-glucose index (CTI) and cholesterol-high-density lipoprotein-glucose index (CHG) have both been implicated in adverse cardiovascular outcomes, their comparative predictive performance for incident heart disease amon...

Large Language Model for Verilog Code Generation: Literature Review and the Road Ahead

Code generation represents a critical intersection of Software Engineering (SE) and Artificial Intelligence (AI). Within this broader landscape, Verilog, as a representative hardware description language (HDL), is fundamental to Electronic Design Automation (EDA), recent research...

Dynamic Uncertainty Learning with Noisy Correspondence for Text-based Person Retrieval

Text-Based Person Retrieval (TBPR) aims to locate a person in an image database based on a natural language description. While effective in theory, TBPR faces substantial challenges in real-world scenarios due to noisy correspondences —misaligned or weakly related image-text pair...

Super-resolution CT-based intratumoral and peritumoral radiomics analysis for trinary classification of PD-L1 status in lung adenocarcinoma ≥ 1 cm

<title>Abstract</title> Objectives To explore the potential of super-resolution CT-based intratumoral and peritumoral radiomics analysis for the trinary classification of PD-L1 status in lung adenocarcinoma with a diameter of ≥ 1cm, aiming to enhance the accuracy of PD-L1 status...

ElectrochemiluminescenceMicroscopy

Abstract Electrochemiluminescence (ECL) microscopy is an emerging imaging technology that combines electrochemistry with optical microscopy. It operates without external light excitation, effectively eliminating photobleaching, phototoxicity, and scattered light noise, and thus e...

Efficacy of Concentrated Growth Factors in Regulating Macrophage Immune Responses and Promoting Wound Healing After Plastic Surgery

OBJECTIVE: To evaluate the clinical effect of concentrated growth factor (CGF) on postoperative wound healing after plastic surgery, and to explore its association with changes in local immune-inflammatory markers and macrophage-related indicators. METHODS: Ninety-six patients wi...

Modular Sensory and Morphological Adaptations Underlying Fresh-Fruit Exploitation in Drosophilid Flies

(1) Background: Drosophilid flies oviposit in damaged or fermenting substrates, whereas D. suzukii prefers to lay eggs in ripening fruits. This ecological shift requires females to recognize fruit-stage cues while overcoming the mechanical barrier imposed by fresh-fruit surfaces....

Evaluationof 18F-FPPA as a PositronEmission Tomography Radioligand for Imaging CSF1R in LPS-Induced RatModel of Neuroinflammation

Abstract Noninvasive detection of microglia is crucial for monitoring their spatiotemporal dynamics and facilitating early medical intervention during the prodromal stages of these neuroinflammatory diseases. Colony-stimulating factor 1 receptor (CSF1R) is a promising imaging bio...

Adaptive estimation method for pavement adhesion coefficient integrating visual and dynamic data

The road adhesion coefficient is widely recognized as a key factor affecting vehicle active safety control. Accurate estimation of this parameter faces challenges such as visual interference and weak observability of vehicle dynamics under low excitation conditions. This paper pr...

Superconductivity from doping symmetric mass generation insulators: application to La3Ni2O7 under pressure

Abstract We investigate the bilayer nickelates as a platform to realize the symmetric mass generation (SMG) insulator, a featureless Mott insulator that arises due to the Lieb-Schultz-Mattis (LSM) anomaly cancellation in bilayer spin-1/2 lattice systems. Through a single-orbital...

Niche-dependent immunometabolic regulation of tissue repair and regeneration

Tissue repair restores structural integrity and functional homeostasis after injury through coordinated interactions among immune cells, structural compartments, and extracellular matrix remodeling, ultimately culminating in tissue-resident regenerative programs. Increasing evide...

Vaccinia-related kinase 2 confers pancreatic cancer with gemcitabine resistance through TPI1-driven aerobic glycolysis

Abstract Gemcitabine(GEM)-based chemotherapy is considered the first-line regimen for pancreatic cancer(PC), but the poor responsiveness and chemoresistance greatly limit its application. Metabolic reprogramming, especially aerobic glycolysis, which is regulated by glycolytic enz...

Lamellar high-entropy TiVCrMoC3 MXene enabling excellent hydrogen storage kinetics and cyclic stability of MgH2 via multi-phase interfaces and multiple transition metals effects

MgH2 is a promising hydrogen storage medium, but its industrial use is hindered by high dehydrogenation temperatures and sluggish kinetics. Herein, a lamellar high-entropy TiVCrMoC3 MXene was synthesized via HF-mediated etching of a TiVCrMoAlC3 MAX precursor and integrated into M...

Redox‐Mediated Ligand Exfoliation Enables High‐Density Single‐Site Molecular Catalysts for CO 2 Electroreduction

ABSTRACT Conventional strategies for fabricating single‐site electrocatalysts often suffer from metal aggregation and insufficient exposure of active sites, limiting their efficiency in CO 2 electroreduction. Here we present a redox‐mediated ligand exfoliation method to construct...

Quantifying the role of nitrogen in achieving global Sustainable Development Goals

Abstract Achieving the 2030 Sustainable Development Goals (SDGs) requires balancing well-being with environmental protection, yet the role of nitrogen across these goals remains poorly understood. Here, we show how dietary nitrogen intake and nitrogen release to air and water are...

Multimember Unit–Based Topology Optimization of Cable-Supported Grid Structures

Abstract Cable-supported grid structures, integrating rigid and flexible components, represent a lightweight and efficient structural form. Conventional topology design methods based on single-member units often produce incomplete upper grids and lower cable-supported structures...