Yonsei University

FrottarX: An Effortful Visual Logging and Reflection System to Support Embodied Engagement with Physical Exhibits

Visual logging tools such as cameras allow people to easily document physical objects, but their effortless nature often shifts attention toward recording rather than attentive observation, limiting engagement with the actual physical environments. We present FrottarX, a visual l...

Beyond conventional immunosuppression: tailoring perioperative management protocols for clinical xenotransplantation

Clinical xenotransplantation offers a conceptually unlimited supply of donor organs, owing to transformative advances in gene-editing technologies. However, the pharmacological and physiological distinctions between allo- and xenotransplantation pose a major challenge. Unlike all...

ALKBH5-Dependent m 6 A Demethylation Promotes Cardiac Aging Through SLC38A3 Reduction and Glutamine Metabolic Alteration

BACKGROUND: N 6 -methyladenosine (m 6 A) modification has been linked to various types of physiological and pathological bioprocesses. However, the exact role of m 6 A mRNA methylation in cardiac aging is largely unknown. Here, we show that ALKBH5 (alpha-ketoglutarate-dependent d...

Trastuzumab plus nivolumab with gemcitabine and cisplatin as first-line therapy for HER2-positive unresectable biliary tract cancer: a phase 1b/2 trial

Biliary tract cancers (BTCs) are associated with poor outcomes despite recent incorporation of immune checkpoint inhibitors into first-line chemotherapy. Human epidermal growth factor receptor 2 (HER2) overexpression or amplification defines a therapeutically targetable subset of...

Paradoxical prognosis of extracellular vesicle-derived miR-4435 expression in advanced colorectal cancer

Abstract Extracellular vesicle (EV)-derived microRNAs are promising non-invasive biomarkers for colorectal cancer (CRC), but their stage-specific prognostic significance remains unclear. We evaluated circulating EV-derived miR-4435 and its target TIMP3 in a retrospective cohort o...

Deep Learning–Based Reconstruction in Ultra-Low-Dose CT of the Ankle and Foot: A Comparative Study with Hybrid Iterative Reconstruction

Objectives: To evaluate the quantitative and qualitative performance of ultra-low-dose CT with deep learning image reconstruction (DLR) compared to conventional hybrid iterative reconstruction (IR) in patients with ankle and foot fractures. Methods: A total of 32 patients (mean a...

Survival impact of repeated endobiliary radiofrequency ablation in patients undergoing durvalumab plus gemcitabine and cisplatin for extrahepatic cholangiocarcinoma (BRAVE trial): study protocol for an international multicenter randomized controlled trial

Extrahepatic cholangiocarcinoma (eCCA) often presents with unresectable disease and obstructive jaundice. Systemic therapy with gemcitabine–cisplatin plus durvalumab (GCD) is an international standard; however, the median overall survival (OS) remains about 1 year. Endobiliary ra...

Antiviral activity of Cirsium japonicum var. spinossimum extract and its flavonoid cirsimaritin against human coronavirus OC43

Coronaviruses cause a wide range of diseases, ranging from the common cold to severe illnesses such as COVID-19. Although vaccines and therapeutics against COVID-19 have been developed, recent reports have documented the emergence of viral variants with reduced susceptibility to...

High-Spatiotemporal and Multimodal Soft Tactile Interface with Layered Architecture for Simultaneous Structural and Thermal Perception

Advanced robotic systems require tactile perception to interact reliably with objects in environments where visual information is limited by occlusion, illumination variations, and focusing issues. However, conventional tactile sensors are limited to single-stimulus recognition a...

The short-form health psychological capital questionnaire: psychometric validation and measurement invariance across Thailand and the United States

Health Psychological Capital (PsyCap) reflects individuals’ positive psychological resources, including hope, efficacy, resilience, and optimism, for managing health-related challenges. Although PsyCap is widely studied and applied, few validated non-English instruments are avail...

Hospitalisation in cirrhosis is linked to distinct gut microbiome structural and functional profiles: a multinational metagenomic study

Background Hospitalisations represent major clinical events in cirrhosis, yet prediction based on clinical variables alone remains limited. Objective Given the role of the gut microbiome in disease progression, we evaluated whether gut metagenomic profiles are associated with 90-...

Distance and Coexistence: The Urban Transformation of Itaewon and the Seoul Central Mosque

Recently, intensifying resident opposition and the proliferation of exclusionary discourses surrounding mosque construction in one of major cities in South Korea have generated significant public controversy, contributing to the continued delay of such projects; yet, in contrast,...

Data-driven nonlinear seismic response prediction method for building structures by synthesizing structural metadata and seismic characteristics

This study proposed a data-driven prediction method combining structural metadata and seismic characteristics to effectively predict the nonlinear seismic responses of structures. The featured method derives structural metadata such as natural period (T), strength ratio (SR), and...

Conserved and rewired MAPK networks in human fungal pathogens

Abstract Mitogen-activated protein kinase (MAPK) cascades are among the most ancient and evolutionarily conserved signalling modules in eukaryotes, translating extracellular cues into adaptive transcriptional and metabolic outputs through a hierarchical three-tier kinase architec...

Noise-adaptive hybrid quantum convolutional neural networks based on depth-stratified feature extraction

Hierarchical quantum classifiers, such as quantum convolutional neural networks (QCNNs), represent recent progress toward designing effective and feasible architectures for quantum classification. However, their performance on near-term quantum hardware remains highly sensitive t...

Layer-by-Layer Electrode Design Integrating a Macroporous Carbon-Nanotube Skeleton for an Anion-Exchange Membrane Water Electrolyzer

Abstract Three-dimensional porous electrodes (anodes and cathodes) using only non-noble-metal electrocatalysts are important for enhancing the performance of anion-exchange membrane water electrolysis (AEMWE), contributing to reduced green-hydrogen production costs. This study de...

A vision-language conditioned agent for autonomous excavator operations in physics-based simulation

This study presents a vision-language conditioned agent for autonomous excavator operations in physics-based simulation. A semantic action-based instruction scheme is introduced, in which natural language instructions describe excavator action units with target specifications. Th...

Dimensional Changes of the Peri‐Implant Mucosa Applying a Suture‐Free Wound Closure Using a Healing Abutment Attachment: A Randomised Controlled Clinical Trial

ABSTRACT Aim To compare peri‐implant soft‐tissue dimensional changes following wound closure using a suture‐free healing abutment attachment (HAA) compared to conventional suturing during implant surgery. Materials and Methods Thirty patients who were randomly allocated to the HA...

Comparison of stool DNA–based SDC2 methylation testing and repeat fit for advanced colorectal neoplasia in fit-positive individuals: a multicenter prospective exploratory study

Abstract Background and Aim Fecal immunochemical test (FIT)–based colorectal cancer (CRC) screening is limited by false-negatives due to bleeding dependence and a high false-positive burden. We compared the diagnostic accuracy of stool DNA–based SDC2 methylation testing versus re...

Ultrafast Nuclear Rearrangement Governs Excited‐State Radial π‐Conjugation and Electron Transfer Dynamics in Organic Nanoring

ABSTRACT Radial π‐conjugation provides a unique platform for extending electronic delocalization in cyclic molecular architectures. Although radial π‐conjugation is relatively robust against static disorders in the ground state, both theoretical and experimental observations indi...