Yonsei University

Comparative study on the clinical effectiveness of low-concentration cyclosporine eye drops in patients with dry eye disease

Purpose This study aimed to evaluate the efficacy and safety of low-concentration, nanoparticle-based cyclosporine eye drops (SCAI-001 0.01% and SCAI-001 0.02%) compared to those of the conventional Restasis ® (cyclosporine 0.05%) emulsion for dry eye disease (DED). Methods In th...

Comparison of vascular access outcomes in octogenarian patients undergoing hemodialysis

Background: The number of patients aged ⩾80 years with end-stage kidney disease is increasing, making vascular access selection increasingly challenging. Although arteriovenous fistula (AVF) is generally preferred, its advantages over arteriovenous graft (AVG) in very elderly pat...

Laser-induced acoustic shockwave treatment using a diamond particle patch for rolling acne scars: a case series

Rolling acne scars are characterized by dermal tethering and are traditionally treated with subcision.This case series evaluated the clinical efficacy and safety of laser-induced acoustic shockwave treatment utilizing a diamond particle patch, a novel, non-invasive, and non-therm...

The effect of thickness, arch type, and storage duration on the dimensional stability and seating accuracy of 3d-printed implant surgical guides

This study investigated the effects of guide thickness, arch span, and storage duration on the dimensional stability and seating accuracy of 3D-printed implant surgical guides. Forty-eight surgical guides were fabricated using stereolithography (SLA) in partial-arch (PA) and full...

One- and Two-Particle Spectral Gap Identities for the Symmetric Inclusion Process and Related Models

Abstract The symmetric inclusion process (SIP) models particles diffusing on a graph with mutual attraction. We recently showed [KS24] that, in the log-concave regime (where diffusivity dominates interaction), the spectral gap of the conservative SIP matches that of a single part...

Unveiling the Structural Advantages in PTFE‐Based Dry‐Processed Electrodes for Sulfide‐Based All‐Solid‐State Batteries via 3D Microstructure‐Resolved Analysis

ABSTRACT All‐solid‐state batteries (ASSBs) employing sulfide‐based solid electrolytes (SEs) are promising candidates for next‐generation lithium‐ion batteries owing to their high energy density and safety. Their electrochemical performance is strongly influenced by the electrode...

Interfacial engineering of sulfur-modified g-C3N5/V2O5 heterostructures for enhanced overall water splitting and sonophotocatalytic tetracycline degradation

Electrochemical water splitting (EWS) and photocatalytic advanced oxidation processes (AOPs) are promising approaches for clean hydrogen production and environmental remediation; however, their efficiency is often limited by high overpotentials, rapid charge recombination, and po...

Shear-transfer mechanisms in ultra-high-performance concrete beams reinforced by externally web-bonded steel plates

This study investigated a reinforced ultra-high-performance concrete (UHPC) beam in which conventional stirrups were replaced with externally web-bonded steel plates on the web (RUB-WSPs) to enhance the structural efficiency and construction productivity. To study the shear perfo...

Administration of a phosphodiesterase 4B inhibitor reduces hippocampal neuronal cell death after global cerebral ischemia

Abstract Global cerebral ischemia (GCI) causes widespread neuronal injury, with hippocampal neurons being particularly vulnerable. This study examined whether post-GCI treatment with amlexanox (AMX), a phosphodiesterase 4B (PDE4B) inhibitor, reduces hippocampal neurodegeneration...

Bridging the gaps: how knowledge and access to care influence timely cholera treatment and reduce deaths in Nampula Province, Mozambique

Despite global efforts to improve cholera case management and reduce case fatality, persistent gaps remain in understanding local health-seeking behaviors and community knowledge. This study aimed to investigate these factors in Nampula province, Mozambique, which experiences fre...

Entrainment of prefrontal theta synchrony increases interbrain coupling and enhances social interaction in mouse models of autism

Social interaction requires the integration of information about self, other, and shared context. One of the proposed mechanisms supporting this coordination is interbrain synchrony – correlated neural activity between interacting individuals – yet its role in shaping social beha...

Deep learning in reduced-order space accelerates high-resolution multi-model climate downscaling

Regional climate projections using dynamical models are computationally intensive, and generating high-resolution multi-model ensembles can be prohibitively expensive. Here, we present a lightweight deep-learning downscaling framework that generates high-resolution sea surface te...

Fatigue Life Prediction of Composite–Steel Single-Lap Hybrid Joint with Experimental Calibration Method

Abstract The study explored a fatigue life prediction framework incorporating an experimentally derived calibration approach for composite–steel hybrid single-lap joints. Since the overlap length of hybrid joints governs the load transfer path, stress distribution, and adhesive-b...

Evorpacept plus trastuzumab, ramucirumab and paclitaxel in HER2-positive gastric cancer: a randomized phase 2 trial

Evorpacept blocks the CD47–signal regulatory protein α interaction, enhancing antibody-dependent cellular phagocytosis. In the phase 2 portion of ASPEN-06 (a multicenter, open-label, randomized phase 2/3 study), 127 patients with pretreated, human epidermal growth factor receptor...

Can Audiometric Configuration Predict Which Patients Derive Greater Speech Intelligibility Benefit from Hearing Aid Fitting?

Background: Although hearing aids improve audibility in patients with sensorineural hearing loss (SNHL), improvements in maximal speech intelligibility vary substantially among individuals, and reliable predictors of hearing aid benefit remain lacking. We investigated whether aud...

An Accelerated Longitudinal Design Study Examining Emotional Engagement toward Learning Science from Grades 3 through 12

Abstract As educators, we often see the enthusiasm for learning science in schools starting out strong in primary years and then fading as student progress into middle and secondary school. The motivation of this study is to offer a picture of how students’ emotional engagement i...

Journeys of Parents with LGBTQ+ Children: How Trauma and Healing Reshape Identity and (Mis)Informating Practices

This study examines how parents of LGBTQ+ individuals in South Korea navigate the emotional rupture fueled by fear, isolation, and disorientation after learning their children’s queer identity, encounter queer-related (mis)information as a way of coping with this emotional toll,...

Health-related quality of life in patients with spinal muscular atrophy receiving nusinersen and their caregivers: a cross-sectional study

Spinal muscular atrophy (SMA) is a rare neuromuscular disorder characterized by progressive motor decline. Although nusinersen has improved survival and motor outcomes, patients and caregivers continue to face substantial medical and psychosocial challenges. As treatment goals ha...

Structural Brain Volumes and Delay Discounting

This cross-sectional study evaluates a multilayer perceptron model for estimating delay discounting among college-aged adults.

ALKBH5-Dependent m 6 A Demethylation Promotes Cardiac Aging Through SLC38A3 Reduction and Glutamine Metabolic Alteration

BACKGROUND: N 6 -methyladenosine (m 6 A) modification has been linked to various types of physiological and pathological bioprocesses. However, the exact role of m 6 A mRNA methylation in cardiac aging is largely unknown. Here, we show that ALKBH5 (alpha-ketoglutarate-dependent d...