Institution
Yonsei University
Recent research
- AI & ComputingOpen access
Implementation Strategies for Real-World Evidence (RWE) Based Post Reimbursement Management
Real-world evidence (RWE) refers to clinical evidence generated through the processing and analysis of real-world data (RWD), which are routinely collected from real-world clinical settings rather than from controlled experimental environments such as randomized clinical trials.T...
- Health & MedicineOpen access
Objective Hwa-byung (HB) is a syndrome associated with stressful events within Korea’s social and cultural contexts. The clinical symptoms of HB may be associated with autonomic imbalance. This study investigated the neurophysiological characteristics of HB by comparing heart rat...
- Health & MedicineOpen access
Abstract Background REM sleep behaviour disorder (RBD) is the strongest prodromal marker of alpha-synucleinopathies, but whether a brief questionnaire carries prognostic information for Lewy body dementia is unclear. We tested whether criteria-based probable RBD (pRBD)—a question...
- Health & MedicineOpen access
The landscape of allele-specific expression in human kidneys
Allele-specific expression (ASE), the preferential expression of one gene copy, is a key mechanism of genomic regulation. However, its role in human kidney disease remains poorly understood. In this study, we generated a high-quality, genome-wide ASE map using paired whole-genome...
- Climate & EnvironmentOpen access
North Atlantic chlorophyll blooms modulate European hydroclimate and terrestrial productivity
Marine and terrestrial ecosystems are usually treated as separate components of the global carbon cycle, and whether variability in ocean biology reaches plant growth on land has remained unclear. Here we show that phytoplankton blooms in the high-latitude North Atlantic are link...
- Health & MedicineOpen access
The 2025 Korean Guidelines for Cardiopulmonary Resuscitation provide updated, evidence-based recommendations to optimize the transition from intrauterine to extrauterine life. While approximately 85% of term newborns initiate spontaneous breathing independently, timely interventi...
- Health & MedicineOpen access
Pediatric cardiac arrest primarily arises from asphyxia in infants and trauma in older children, contrasting with adult etiologies dominated by cardiac events. This underscores prevention as the cornerstone of pediatric basic life support, through injury mitigation like child res...
- Engineering & Technology
Abstract Developing high-performance membranes for H2/CH4 separation is a critical imperative for the advancement of the hydrogen economy. However, conventional polymeric membranes often suffer from the intrinsic trade-off between permeability and selectivity, as well as the tech...
- Health & MedicineOpen access
The 2025 Korean pediatric advanced life support guideline update introduces clinically important revisions emphasizing airway strategy, physiologic resuscitation targets, post-cardiac arrest hemodynamics, neuroprotection, and extracorporeal support. In out-of-hospital pediatric c...
- Health & Medicine
The ISHLT Consensus document for the selection of lung transplant candidates recommends frailty assessment as part of a comprehensive candidacy evaluation. Missing from this and other recent consensus documents were practical recommendations on which frailty measures to consider...
- Health & MedicineOpen access
[Purpose] The time of day at which exercise is performed influences physiological responses and performance, and thus its health benefits. This study investigated whether electroencephalographic (EEG) and autonomic nervous system responses to morning versus evening exercise diffe...
- Physics & SpaceOpen access
We present the MEGATRON suite of cosmological radiation hydrodynamics simulations following the formation of Milky Way-mass galaxies from the earliest cosmic epochs when Population III stars form to Cosmic Noon. The suite represents the first set of cosmological simulations that...
- Health & MedicineOpen access
Stereotactic body radiation therapy (SBRT) is a noninvasive, high-precision radiation technique that delivers a high dose to the tumor in a limited number of fractions, typically five or fewer, and is increasingly used as a curative-intent option for hepatocellular carcinoma (HCC...
- Materials & EnergyOpen access
Spatial Proteomics as a Potential Decision‐Support Layer for Early Melanoma: A Narrative Review
Distinguishing early melanoma from borderline, atypical, or biologically intermediate melanocytic lesions remains one of the most consequential and urgent diagnostic challenges in dermato-oncology, since melanoma causes nearly 95% of skin cancer deaths. This narrative review esta...
- BiologyOpen access
Objectives: Anthracycline remains a cornerstone of breast cancer chemotherapy.Although pulsed electromagnetic field (PEMF) exposure enhances doxorubicin efficacy, whether this effect extends to other anthracyclines is unclear.This study investigated whether PEMF potentiates dauno...
- Health & MedicineOpen access
Hepatocellular carcinoma (HCC) displays significant molecular heterogeneity that clinical staging alone does not fully account for when assessing the risk of recurrence following curative treatment. To address this, we developed a multi-cohort survival modeling framework that tra...
- Physics & SpaceOpen access
MEGATRON: how the first stars can create an iron metallicity plateau in the smallest dwarf galaxies
We study the stellar mass-iron metallicity relation of dwarf galaxies in the new high-resolution MEGATRON cosmological radiation-hydrodynamics simulations. These simulations model galaxy formation up to z ≈ 8 in a region that will collapse into a Milky-Way-like galaxy at z = 0 ,...
- BiologyOpen access
Alzheimer’s disease through the lens of mesenchymal drift: the collapse of cellular identity
Cellular identity is maintained by precise epigenetic regulation, but chronic stress and aging can disrupt this control, leading to mesenchymal drift (MD). Unlike the coordinated process of epithelial-mesenchymal transition (EMT), MD is a stochastic, lineage-independent phenomeno...
- Society & Economics
Research Findings: Based on the lived experiences of Head Start (HS) teachers, this study aims to understand their perceptions of their psychological and physical well-being, the relationships between their work and well-being, and the support they need in the workplace to improv...
- Physics & SpaceOpen access
We present three cosmological radiation-hydrodynamic zoom simulations of the progenitor of a Milky Way-mass galaxy from the MEGATRON suite. The simulations combine on-the-fly radiative transfer with a detailed non-equilibrium thermochemical network (81 ions and molecules), resolv...