Yonsei University

Nontoxic mRNA vehicles based on electrically neutral self-assembling peptides

The cationic molecules and low-molecular-weight amphiphiles commonly used in nonviral gene delivery vehicles often induce adverse nonspecific effects, notably cytotoxicity and detergent-like unfavourable membrane activity. To address these limitations, here we report the developm...

Clinical Application of Circulating Tumor DNA in Surgically Treated Esophageal Squamous Cell Carcinoma

Background: Esophageal squamous cell carcinoma (ESCC) is associated with a high recurrence rate and is one of the most aggressive malignancies. Recurrence is mainly detected via imaging modalities; however, postoperative imaging surveillance has disadvantages, including reduced s...

Mélange diapir origin for Neo-Tethyan ridge-subduction magmatism

The mélange diapir model invokes physical mixing of partially melted slab components with mantle wedge peridotite, enabling material transfer from the subducted slab to the overlying mantle wedge. However, identifying distinctive igneous rock suites generated through this process...

From international experience to global mindset: The contingent role of organizational context

Global mindset is widely recognized as essential for navigating cultural diversity and strategic complexity in multinational enterprises (MNEs). While prior research has identified individual factors influencing its development, less is known about how individual and organization...

Macrophage trained immunity requires a mitochondrial glutamine-restriction checkpoint for antitumor protection in mice

Trained immunity enables innate immune cells to acquire memory-like responses, offering a strategy to enhance antitumor immunity. However, the metabolic‒epigenetic mechanisms underlying this process remain poorly defined. Here, we show that lipopolysaccharide-induced macrophage t...

The burden of low back pain in the United States, 1990 to 2021

Low back pain (LBP) is a major global health concern and remains a leading contributor to healthcare expenditure in the United States (US). Few recent studies have systematically analyzed the temporal, geographic, and demographic patterns of LBP burden and its associated risk fac...

Building a Physics-Aware AI Ecosystem for Solid-State Hydrogen Storage Materials

Abstract Hydrogen storage remains a central bottleneck for scalable hydrogen energy systems due to the multiscale and coupled nature of the thermodynamics, kinetics, and microstructural evolution of hydrogen storage materials (HSMs). Although artificial intelligence (AI) has acce...

Lipid Mediators Derived from Docosahexaenoic Acid Alleviate Periodontal Inflammation and Alveolar Bone Loss in Periodontitis Associated with Suppression of the NF-κB and STAT3 Signaling Pathways

Background: Lipid mediators (LM), comprising 17S-hydroxy-docosahexaenoic acid, resolvin D5, and protectin DX in a ratio of 3:47:50, were naturally generated from docosahexaenoic acid by soybean lipoxygenase and exhibit potent anti-inflammatory activities. However, their therapeut...

Cervical sagittal alignment differences according to scapular rotational posture

Scapular posture may influence cervical biomechanics because of the anatomical and functional linkage between the cervical spine and the scapulothoracic complex. Although abnormal scapular positioning has been associated with neck pain and altered muscle activity, radiographic ev...

ComplexCore-Satellite Nanoparticles with Trench-StructuredShells and Cavities for Highly Sensitive SERS-Based Lateral Flow Assays

Abstract Herein, we report a multistep synthetic strategy for the fabrication of complex and multifunctional core-satellite nanoparticles with trench-structured shells and cavities (CSTs). Starting from cuboctahedral Au nanoparticles, Pt, Ag, and Au were sequentially deposited in...

Hyaluronic Acid Hydrogel Incorporating Dexpanthenol-Engineered Extracellular Vesicles for Accelerated Wound Closure and Mitigated Secondary Infection Risk

Background: Loss of epithelial integrity leaves the wound bed open to opportunistic bacterial colonization, and the risk of secondary infection persists for as long as the defect remains unclosed. Wound dressings must therefore provide an immediate external barrier while accelera...

Impact of Observation Density of Next-Generation GeoHIS on Global Numerical Model Performance: A KIM-OSSE Study

The geostationary hyperspectral infrared sounder (GeoHIS) provides atmospheric variables at high spatiotemporal resolution. Consequently, GeoHIS can provide valuable information for improving real-time forecasting and enhancing the performance of numerical weather prediction (NWP...

End-to-end deep learning-based determination of programmable shunt valve settings from standard two-view skull radiographs

Accurate identification of programmable shunt valve settings is crucial for managing patients with hydrocephalus, as unintended setting changes can lead to overdrainage or underdrainage of cerebrospinal fluid (CSF). Existing artificial intelligence (AI) models primarily focus on...

Clinical Characteristics and Outcomes of Pediatric Patients With Long QT Syndrome: A Korean Multicenter Cohort Study

This multicenter nationwide cohort study comprehensively analyzed the clinical features, genetic architecture, and outcomes of Korean pediatric patients with long QT syndrome (LQTS).Prolonged QT intervals, fetal arrhythmia, and LQT2/3 genotypes compared to LQT1 were independent r...

Unipolar Barrier Near‐Infrared 2D Photodetectors for 3D Image Sensors

ABSTRACT Photodetectors sensitive to the near‐infrared (NIR) range are of great importance for applications in machine vision, autonomous driving, and three‐dimensional (3D) imaging under low‐light or adverse weather conditions. Recently, two‐dimensional (2D) semiconductors have...

Synergetic Enhancement in Thermoelectric Performance via Localized Magnetic Moments and Lattice Softening

ABSTRACT Magnetism‐assisted transport is achieved in Mn‐containing SnSe magnetic nanocomposites, where superparamagnetic MnSe nanoprecipitates are introduced to modulate both carrier and phonon scattering. Transmission electron microscopy reveals well‐dispersed 5–10 nm MnSe inclu...

Reflex Charging for Anion‐Derived Solid Electrolyte Interphase Formation

ABSTRACT Lithium (Li) metal offers exceptional energy density but suffers from unstable interphases that lead to dendrite growth and poor reversibility. Because the interphase is established during the earliest stages of operation, controlling its formation is critical for stabil...

Dynamic load transfer behaviour of piled raft foundations in saturated sand

This study investigates the dynamic response and load-sharing mechanism of a piled raft foundation subjected to earthquake loading. A series of 1g shaking table tests was conducted to analyse the dynamic behaviour of soil–structure interaction. The experimental setup involved mod...

Reflex Charging for Anion‐Derived Solid Electrolyte Interphase Formation

ABSTRACT Lithium (Li) metal offers exceptional energy density but suffers from unstable interphases that lead to dendrite growth and poor reversibility. Because the interphase is established during the earliest stages of operation, controlling its formation is critical for stabil...

Interpretable machine learning models for classifying lateral epicondylitis based on wrist range of motion and strength in assembly line workers

Background Lateral epicondylitis (LE) is a prevalent overuse injury among workers performing repetitive wrist movements. Altered wrist range of motion (ROM) and reduced muscle strength occur in individuals with LE; however, their combined utility for classifying LE remains unclea...