Yonsei University

Prenatal PM2.5 exposure drives epigenetic reprogramming of fetal macrophages linked to atopic dermatitis

Abstract Prenatal environmental exposures are increasingly recognized as contributors to atopic dermatitis (AD), yet the underlying mechanisms remain unclear. Fine particulate matter (PM 2.5 ), a complex mixture of airborne pollutants, has been associated with elevated risk of al...

Data-driven personalization of just-in-time adaptive mental health intervention via two-stage reinforcement learning approach

Most digital mental health interventions still deliver uniform content, without accounting for how a user’s fluctuating psychological state interacts with their stable individual characteristics. We propose a two-stage offline reinforcement learning (RL) framework, trained on dat...

Instability control and emission characteristics of methane/hydrogen non-premixed flames under DC electric fields

This study experimentally investigated the Kelvin–Helmholtz instability in methane/hydrogen non-premixed flames induced by velocity differences between the fuel jet and co-flow. Using a co-flow burner, various fuel and co-flow velocity conditions were tested to identify the regim...

Regional CO 2 and CH 4 inversion system using WRF-Chem (v4.4)/DART (v9.8.0) and continuous high-precision observations over the Korean Peninsula

Abstract. Quantifying greenhouse gas (GHG) emissions over complex terrain remains a significant challenge for conventional inversion systems due to the high sensitivity of tracer transport to surface heterogeneity. We develop a high-resolution dual-species GHG top-down inversion...

Initial High-Frequency Amplification Accuracy Predicts Long-Term Hearing Aid Fitting Outcomes: A Real Ear Measurement-Based Study

Background: To investigate whether the accuracy of initial hearing aid amplification verified by real ear measurement (REM) predicts long-term fitting outcomes after one year, and to identify frequency-specific predictors associated with sustained fitting precision. Methods: This...

Chirality-Matched Cyclopropenimine–Thiourea Organocatalysis for Regiocontrolled Ring-Opening Polymerization of Methyl Glycolide

Abstract Poly(lactic-co-glycolic acid) (PLGA) is widely used in biomedical applications owing to its high biodegradability and biocompatibility. Although the ring-opening polymerization (ROP) of methyl glycolide (MeG) offers a route to synthesizing alternating PLGA, the comparabl...

MODEL-informed nivolumab less frequent dosing using virtual patients with solid tumors

Less frequent nivolumab dosing has been assessed for more efficient dosing, but there is no conclusive evidence. In this research, we suggested an appropriate model-informed drug dosing using virtual patients collected from the results of multiple clinical studies to provide a ra...

The Traumatic Event Checklist for North Korean Defectors

Objective This study aimed to develop and validate a trauma checklist specifically designed to capture the complex and culturally unique potentially traumatic events (PTEs) experienced by North Korean defectors (NKDs), in alignment with International Classification of Diseases, 1...

Integrative Genomic Analysis Reveals Molecular and Clinical Disparities between Bladder and Upper Tract Urothelial Carcinoma in K-MASTER Program

Purpose: The clinical outcome of urothelial carcinoma presents significant variability, reflecting its molecular composition, epidemiologic attributes, and primary site of origin. Despite histological similarities, upper tract urothelial carcinoma (UTUC) and bladder urothelial ca...

Development of an artificial intelligence model for predicting cardiovascular disease in MASLD

Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with cardiovascular disease (CVD). Conventional CVD risk scores often fail to reflect MASLD-specific factors. We aimed to develop and validate an artificial intelligence (AI) model for 10-year CVD risk...

Population Pharmacokinetic Comparability of CT-P16 Versus EU-Avastin® and US-Avastin® in Healthy Subjects and Patients with Non-Squamous Non-Small Cell Lung Cancer

CT-P16 (Vegzelma ® ) is a bevacizumab biosimilar approved for indications including non-squamous non-small cell lung cancer. We developed an integrated population pharmacokinetic model pooling data from two phase I studies in healthy subjects and one phase III study in patients w...

Objective Correlates of Activity Limitation in Korean Adults: A Combined Complex-Survey Regression and Explainable Machine-Learning Analysis of KNHANES 2019－2021

Background/Objective: This study aimed to identify objective, potentially intervention-relevant correlates of activity limitation in Korean adults using complex-survey logistic regression and explainable machine learning.A secondary aim was to examine how inclusion of self-rated...

Factors associated with the health-related quality of life of adolescents with atopic dermatitis in South Korea: a cross-sectional study

PURPOSE: Atopic dermatitis (AD) in adolescents has received less attention than AD in infants and children. However, AD can persist or worsen after school age and affect health-related quality of life (HRQoL) beyond adolescence. This study aimed to examine HRQoL and its associate...

Combined Associations of Alcohol Consumption Frequency and Healthy Lifestyle With Risk of Sudden Cardiac Arrest: A Multicenter Case–Control Study

BACKGROUND: Frequent alcohol consumption is a cardiovascular risk factor, but its association with sudden cardiac arrest (SCA) across lifestyle profiles remains unclear. We examined the combined associations of drinking frequency and Healthy Lifestyle Score (HLS) with SCA. METHOD...

Nutritional support for critically ill patients by the Korean Society for Parenteral and Enteral Nutrition—part II: a clinical practice guideline

Purpose: Nutritional therapy is an essential component of intensive care management. Appropriate nutritional support may reduce infectious and metabolic complications and promote recovery in critically ill patients. However, nutritional practices vary across institutions, and int...

Risk and protective factors for the intergenerational transmission of child maltreatment in South Korea: a secondary analysis of data from the Family with Children’s Life Experience Survey

PURPOSE: This study aimed to identify ecological risk and protective factors associated with membership in latent classes characterized by heterogeneous associations between parental adverse childhood experiences (ACEs) and the intergenerational transmission of child maltreatment...