West China Hospital of Sichuan University

Sintilimab plus Bevacizumab biosimilar IBI305 and chemotherapy as a first-line treatment in advanced gastric or gastroesophageal junction adenocarcinoma (SBAGA): a single-arm, phase Ib/II study

Adding anti-PD-1 or anti-VEGF therapy to chemotherapy improves survival in patients with advanced gastric cancer, yet outcomes remain poor. This Phase Ib/II trial aimed to evaluate the efficacy and safety of combining sintilimab, the bevacizumab biosimilar IBI305, and CapeOX chem...

Bacterial etiology, antimicrobial susceptibility, and clinical outcomes in cervicofacial space infections before, during, and after the COVID-19 pandemic: a 10-year single-centre study

To investigate epidemiological trends of cervicofacial space infections in Western China, including pathogen distribution, antimicrobial resistance, and the impact of the COVID-19 pandemic on pathogen susceptibility and patient outcomes. Clinical data from 542 hospitalized patien...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

A Randomized Controlled Trial of Targeted Training on Nursing Interns' Preparedness for Public Health Emergencies: A Study From West China Hospital, 2022

OBJECTIVE: To explore the effects of coronavirus-specific education and training on nursing interns' self-efficacy, stress levels, and knowledge. METHODS: 74 nursing interns were randomly allocated to either an intervention group (n = 37) or a control group (n = 37). The interven...

EPI-Sense: an integrated hemodynamic sensing and analysis system for early pressure injury warning

Pressure injury poses a critical challenge in geriatric care. Current computer-aided diagnosis is limited by an exclusive reliance on surface texture, neglecting subcutaneous hemodynamics essential for distinguishing Reactive Hyperemia from Stage 1 PI and detecting Deep Tissue Pr...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

A deep learning model utilizing H&E-stained images for predicting HER2-low expression in breast cancer

The development and clinical application of novel HER2-targeted antibody-drug conjugates (ADCs) have significantly improved outcomes for breast cancer patients with HER2-low expression. The efficacy of such therapies critically depends on accurate assessment of HER2-low status. H...

Hepatocyte-intrinsic ER stress and NRF2 initiate primary sclerosing cholangitis, providing therapeutic insights

primary sclerosing cholangitis (PSC) is a severe liver disease that can progress to cholangiocarcinoma. Therapeutic development has been hindered by the rarity of PSC and by its poorly understood origin, which reflects incompletely defined genetic and environmental risk factors....

Chinese expert consensus on extraintestinal manifestations of inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic, relapsing, inflammatory condition of the gastrointestinal tract that primarily includes Crohn's disease and ulcerative colitis. Beyond the typical gastrointestinal symptoms, IBD is frequently associated with various extraintestinal m...

Clinical study on the combined predictive value of admission neutrophil-to-lymphocyte ratio and stress hyperglycemia ratio for early neurological deterioration in acute ischemic stroke

Early neurological deterioration (END) affects short-term prognosis in acute ischemic stroke. Inflammation and stress-related glucose dysregulation may contribute to END, but their incremental predictive value remains unclear. To evaluate the associations of admission neutrophil-...

A systematic review and meta-analysis of the effects of continuous glucose monitoring compared to self-monitoring of blood glucose on glycemic control and maternal and infant outcomes in women with gestational diabetes mellitus

Abstract Background Continuous glucose monitoring (CGM) compared to self-blood glucose monitoring (SMBG) has been a controversial topic regarding glycemic control in pregnant women with gestational diabetes mellitus (GDM), as well as maternal and infant outcomes. The aim of this...

TyG-Biomarker discordance profiling identifies metabolically heterogeneous phenotypes with divergent cardiovascular and diabetes risk: metabolomic characterization from the UK biobank

The triglyceride-glucose (TyG) index is a widely used surrogate of insulin resistance, yet it captures only a narrow slice of the broader cardiometabolic dysregulation associated with metabolic dysfunction. Whether individuals with equivalent TyG values harbour meaningfully disti...

Cross-system patterns of physical, psychological and cognitive multimorbidity and 9-year all-cause mortality among middle-aged and older Chinese adults: a prospective cohort study from the China Health and Retirement Longitudinal Study

Cross-system multimorbidity—the co-occurrence of physical, psychological and cognitive disorders—is increasingly recognised as a defining feature of population ageing, yet its relationship with long-term mortality has rarely been examined at the level of specific combinations. Mo...

Social determinants of health and lifestyle in the progression of degenerative bone and joint diseases: a prospective multi-state analysis

Abstract Aims The role of social determinants of health (SDOH) in the progression of degenerative bone and joint diseases (DBJDs) - from initial onset to multimorbidity and mortality - remains unclear. We aimed to assess the associations of SDOH with DBJDs progression, examine th...

Engineered desialylated platelet membrane camouflaged liposomes for the regulation of kupffer cells and hepatic stellate cells in treatment of liver fibrosis

The intercellular crosstalk and reciprocal activation between Kupffer cells (KCs) and hepatic stellate cells (HSCs) are critical drivers of liver fibrosis progression. Nonetheless, the co-regulation of KCs and HSCs is hindered by their distinct anatomical locations and the pathol...

Quantitative Evaluation of Cervical Spine Morphometry: Zero Echo Time MRI Versus Multislice CT

BACKGROUND: For preoperative cervical assessment, both CT and MRI are often required for bony and soft-tissue evaluation, yet CT entails radiation and MRI poorly depicts cortical bone. ZTE offers CT-like contrast in one examination, but whether it correlates with CT for quantitat...

Cross-cultural adaptation and psychometric assessment of the Chinese version of the University of Wisconsin Running Injury and Recovery Index in runners

The University of Wisconsin Running Injury and Recovery Index (UWRI) is a nine-item patient-reported outcome measure assessing self-perceived running ability following running-related injury (RRI). This study aimed to translate and cross-culturally adapt the UWRI into Chinese and...

U-Shaped Association Between Left Ventricular Dimension and Mortality in Patients With Heart Failure

Importance Left ventricular structural assessment is fundamental in heart failure (HF). However, the independent prognostic value of left ventricular size beyond its association with ejection fraction remains poorly defined in real-world, large-scale populations. Objective To inv...

Assembly of Bioactive Superstructures via Metal–Phenolic Complexation for Blood Purification

ABSTRACT Hyperbilirubinemia, which stems from bilirubin accumulation caused by liver failure, can lead to jaundice, multi‐organ damage, and mortality. Hemoperfusion is the most effective detoxification approach, and its efficacy critically depends on the adsorbent system. However...

Iatrogenic botulism induced by cosmetic injection requiring mechanical ventilation: clinical characteristics and outcomes

Introduction Cosmetic iatrogenic botulism is increasingly reported, but data on severe cases complicated by neuromuscular respiratory failure requiring mechanical ventilation remain limited. This study aims to characterize clinical features, treatment, and outcomes of such cases....