West China Hospital of Sichuan University

Multi-omics mapping of TIMP1-associated stromal–myeloid remodeling in autoimmune gastritis and gastric cancer

Abstract Background Autoimmune gastritis (AIG) is a chronic immune-mediated atrophic disease that can induce cancer-related epithelial remodeling, although its association with gastric adenocarcinoma depends on histological and clinical modifiers. Gastric cancer (GC) progression...

Glutaredoxin 1 facilitates colitis recovery by controlling glutathionylation and activity of STAT6 in M2 macrophages

Inflammatory bowel disease (IBD) is characterized by oxidative stress and intractable inflammation. Current therapeutic strategies are far from satisfactory because of its not fully understood pathogenesis. M2 macrophages can promote inflammation resolution and tissue repair, and...

Cholesterol sulfate as a novel theranostic target for sepsis-induced liver injury through Beclin1-mediated autophagy enhancement and pyroptosis suppression

Sepsis remains a life-threatening syndrome, and septic liver injury is a frequent and critical complication for which no specific pharmacological therapy exists. Current biomarkers lack sufficient specificity for early diagnosis and severity assessment, highlighting an urgent nee...

Machine learning identifies plasma-derived exosomal miRNAs associated with low muscle mass in Tibetan patients with rheumatoid arthritis

Sarcopenia poses a significant health burden in aging populations, particularly among patients with rheumatoid arthritis (RA), but current diagnostic approaches face limitations in early detection. This study aims to identify plasma-derived exosomal miRNA features associated with...

Extensive melorheostosis of the upper extremity: Evaluation of disease activity with 99mTc-MDP bone scintigraphy.

Tc-MDP) bone scintigraphy demonstrated intense tracer uptake, indicating high metabolic activity despite the long-term disease course. Three-dimensional computed tomography (CT) reconstruction visualized extensive hyperostosis crossing multiple joints, while magnetic resonance im...

18F-FDG PET/CT of primary malignant melanoma arising from the Eustachian tube region.

F-FDG uptake with a maximum standardized uptake value (SUVmax) of 10.59. Postoperative pathology confirmed malignant melanoma of the right torus tubarius.

Development and validation of a nursing-oriented triage decision tool for prehospital trauma patients in China: a retrospective cohort study

In China, prehospital emergency medical services (EMS) frequently employ nurses as frontline triage personnel, a practice that differs from EMS systems in many Western countries where paramedics typically fulfill this role. However, existing triage tools such as ATLS and CRAMS we...

The Efficacy of Adjuvant EGFR-TKI Therapy for Stage IA Lung Adenocarcinoma with EGFR Mutations: A Retrospective Cohort Study

Abstract Introduction Surgical resection is the standard for early-stage lung adenocarcinoma (LUAD), but recurrence remains a risk for patients with epidermal growth factor receptor (EGFR) mutations. The efficacy of adjuvant EGFR tyrosine kinase inhibitors (EGFR-TKIs) in stage IA...

Comparative efficacy and safety of neoadjuvant and perioperative systemic therapies for resectable locally advanced gastric and gastroesophageal junction adenocarcinoma: a network meta analysis of randomized controlled trials

The optimal neoadjuvant or perioperative systemic strategy for resectable locally advanced gastric cancer (LAGC) and gastroesophageal junction adenocarcinoma (GEJA) remains uncertain. This study compared clinically defined treatment classes rather than individual regimens. PubMed...

Depressive Symptoms Trajectories Across the Transition to Cardiovascular Disease in Middle-Aged and Older Adults: A Multicohort Study

Abstract Aims The long-term depressive symptoms trajectories across the transition to diagnosed cardiovascular disease (CVD) remain poorly characterized. We aimed to investigate trajectories of depressive symptoms before and after incident CVD in multinational aging populations....

Comparative efficacy of various wound dressings on scar formation following thyroidectomy: a systematic review and meta-analysis

Background: Visible cervical scarring remains a common concern following conventional thyroidectomy and may adversely affect cosmetic satisfaction and quality of life. Although several postoperative wound interventions have been introduced to improve scar healing, their comparati...

POU4F3 variants are prevalent in Chinese patients with autosomal dominant non-syndromic hearing loss and concurrent tinnitus

POU4F3 (DFNA15) is an established causative gene for autosomal dominant non-syndromic hearing loss (ADNSHL); however, its mutational spectrum in the Chinese population remains incompletely characterized. This study aimed to expand the mutational spectrum of POU4F3 in the Chinese...

Emotional labor regulation profiles and predictors among institutional elderly care workers: a cross-sectional study in western China

Emotional labor, the management of feelings and expressions to meet emotional demands, is crucial in the elderly care industry. However, this workforce faces challenges such as high turnover, burnout, and a lack of effective emotional management systems. Meanwhile, research on em...

Albumin-Based Biomarkers and Adverse Outcomes in Coronary Artery Disease: A Systematic Review and Meta-Analysis

Background: Albumin-based biomarkers have emerged as practical tools for prognostic assessment in coronary artery disease (CAD), but their comparative prognostic patterns and potential clinical utility have not been systematically evaluated. Methods: We performed a systematic rev...

Site-specific programming characterizes dynamic post-translational acetylation of histone H2B lysine 108 in mouse embryonic stem cells

Dynamic histone modifications are critical for regulating stem cell fate. However, generalized strategies for site-specific programming of histone modifications profiling on unperturbed chromatin in embryonic stem cells (ESCs) remain challenging. In this study, we established a g...

EIF1 coordinates transcriptomic and splicing networks associated with cell cycle dysregulation in diabetic retinopathy

Purpose EIF1, an RNA-binding protein implicated in multiple diseases, remains poorly characterized in diabetic retinopathy (DR). This study therefore investigated EIF1 expression and function in an in vitro model of DR pathogenesis. Methods Human retinal pigment epithelial cells...

Association between serum chloride and all-cause mortality in bronchiectasis: a retrospective cohort study and predictive model establishment based on machine learning

Bronchiectasis remains a chronic respiratory condition with substantial disease burden. While chloride dysregulation plays a role in its pathogenesis, the effect of serum chloride on clinical outcomes remains unclear. This study aims to investigate the association between serum c...

Differentiating Nontuberculous Mycobacterial Lung Disease from Pulmonary Tuberculosis: A Retrospective Study on Clinical Features and a Diagnostic Model

Background: Nontuberculous mycobacterial pulmonary disease (NTM-PD) and pulmonary tuberculosis (PTB) present with similar clinical and radiological features, frequently leading to misdiagnosis. This study aimed to compare NTM-PD with extrapulmonary NTM disease (ENTM) and PTB and...

52‐week ivarmacitinib in moderate‐to‐severe atopic dermatitis: A phase 3 trial

BACKGROUND: Ivarmacitinib, an oral JAK1 inhibitor, improved efficacy outcomes versus placebo at Week 16 in a phase 3 trial in patients with moderate-to-severe atopic dermatitis (AD). OBJECTIVES: To describe efficacy and safety outcomes through Week 52. METHODS: In this multicentr...

Optimal Strain Combinations for Prognostic Prediction in Pulmonary Arterial Hypertension

BACKGROUND: Strain parameters are sensitive indicators of myocardial performance, but the optimal combination for prognostic prediction in pulmonary arterial hypertension remains unclear. METHODS: Patients diagnosed with pulmonary arterial hypertension between June 2013 and June...