West China Hospital of Sichuan University

Machine Learning in Amyloidogenic Polypeptide Research: From Sequence Prediction to Drug Discovery

Abstract Over the past decade, machine learning (ML) has established a transformative paradigm for investigating amyloidogenic polypeptides. Characterized by their propensity to form ordered, β-sheet-rich fibrillar aggregates, these polypeptides are centrally implicated in the pa...

Integrated Proteomic and Phosphoproteomic Profiling Reveals Dysregulated Inflammatory Signaling Networks in Rheumatoid Arthritis

Aberrant protein phosphorylation orchestrates sustained inflammatory immune signaling in rheumatoid arthritis (RA), yet the coordinated remodeling of proteomic and phosphoproteomic landscapes in peripheral blood mononuclear cells (PBMCs) remains poorly resolved via system-level m...

The impact of tranexamic acid on graft function in liver transplantation: A randomised controlled trial

Tranexamic acid (TXA) has been reported to reduce transfusion requirements in liver transplantation (LT). However, clinical evidence regarding the impact of TXA on graft function and other outcomes in liver transplant recipients remains limited. This study aimed to evaluate the e...

Modified Xiaoyaosan Regulates the Neuro-Immune Microenvironment in Chronic Stress: A Preclinical Meta-Analysis and NF-kappaB Pathway Mechanism Exploration

Background: Chronic unpredictable mild stress (CUMS) triggers systemic pathologies, notably depression and endocrine disorders such as hyperprolactinemia (HPRL). Xiaoyaosan (XYS), a classic traditional Chinese medicine formulation, has been proven effective in treating these stre...

Stent-Graft Fracture 18 Years After Hybrid Repair of Thoracoabdominal Aortic Aneurysm: A Possible Risk of Retrograde Reconstruction

We report the case of a patient who underwent hybrid repair for a type V thoracoabdominal aortic aneurysm. The procedure ensured durable aneurysm exclusion and visceral perfusion for 18 years. Eighteen years after surgery, the stent-graft fractured occurred at the visceral artery...

Effect of Duloxetine on the Perioperative Anxiety Status and Stress Response Following Total Hip Arthroplasty: A Randomized Controlled Trial

ABSTRACT Objective The impact of psychological factors on surgical stress response has garnered extensive attention. However, perioperative intervention strategies are still lacking for the total hip arthroplasty (THA) population without psychiatric comorbidities. This study aime...

Effect of adjunctive minocycline on functional recovery and safety in acute ischemic stroke: a systematic review and meta-analysis

Neuroinflammation drives secondary brain injury after acute ischemic stroke. Minocycline, a tetracycline antibiotic with anti-inflammatory properties, has shown promise in preclinical and early-phase trials. The recent EMPHASIS trial necessitates an updated evidence synthesis. We...

Age-Associated Differences in Facial Skin Structure in Chinese Women: a Cross-Sectional Study

Facial skin aging is a process leading to structural degradation and visible phenotypical changes. Prior studies examined age-related skin parameters and suggested accelerated changes occurring in the early 30s, yet precise timing remains insufficiently defined, and few assessed...

Three-year outcomes of combined surgical peripheral iridectomy, goniosynechialysis and goniotomy for advanced primary angle-closure glaucoma: a multicentre study

Aims To assess the 3-year efficacy and safety of combined surgical peripheral iridectomy (SPI), goniosynechialysis (GSL) and goniotomy (GT) for advanced primary angle-closure glaucoma (PACG) without cataract. Methods This was a multicentre prospective observational study with ext...

BMI-adjusted handgrip strength as a functional index to assess fall risk among older adults

This study was devised to explore how body mass index-adjusted handgrip strength (HGS/BMI) is related to subsequent fall risk among older Chinese adults, while also examining whether HGS/BMI demonstrates more consistent associations and more stable sex-specific associations than...

Electroacupuncture for erectile dysfunction in patients after robotic-assisted radical prostatectomy: study protocol for a randomized controlled trial

Erectile dysfunction (ED) is a prevalent and impactful sequelae following robotic-assisted radical prostatectomy (RARP), significantly diminishing patients’ quality of life. Although electroacupuncture is widely employed for ED management in China, robust evidence supporting its...

Strabismus-Net mobile application for nine-gaze photograph-based strabismus diagnosis using dual-stream cross-attention and adaptive feature aggregation

Early detection and intervention of strabismus are crucial for effective treatment, yet traditional diagnostic methods require extensive expertise, often causing diagnostic delays in underserved areas. In this study, we propose and validate a “two-tier” stratified diagnostic syst...

Ultrasound-defined hepatic steatosis and clustering of cardiometabolic abnormalities: endpoint-dependent performance of seven metabolic indices in 356,197 adults

Hepatic steatosis commonly coexists with cardiometabolic abnormalities, but the extent to which an ultrasound finding identifies their clustering in routine health-examination populations remains unclear. We quantified the association between hepatic steatosis and cardiometabolic...

Unexplained intra-abdominal hemorrhage: a case report and literature review

Spontaneous intra-abdominal hemorrhage is a life-threatening emergency with high mortality, often linked to vascular pathologies or visceral organ rupture. This case report details a rare instance of recurrent hemorrhage and reviews etiological insights. A 72-year-old hypertensiv...

Early-life famine exposure and advanced cardiovascular-kidney-metabolic syndrome in Chinese adults: an apparent critical window explained by a birth-cohort gradient

Abstract Background Famine studies repeatedly report window-specific effects on adult disease risk, but because exposure windows are defined by date of birth, window-specific estimates are structurally confounded by birth cohort and by chronological age. We examined whether expos...

Study on the impact of meditation intervention on the white matter structure in schizophrenia

Schizophrenia is associated with abnormal white matter structural connectivity, and meditation has been investigated as an adjunctive intervention for clinical symptoms. This study examined whether an 8-month meditation intervention was associated with longitudinal changes in cli...

Productivity loss associated with type 2 diabetes in China: the trend and projection from 1990 to 2050

Background: Type 2 diabetes (T2D) has become increasingly prevalent among young adults in their prime working years. This study aimed to estimate the productivity-adjusted life years (PALYs) loss associated with T2D among working-age Chinese adults from 1990 to 2021, with project...

Association between in-hospital changes in estimated plasma volume status and worsening renal function in patients with acute heart failure

Worsening renal function (WRF) during treatment for acute heart failure (AHF) has context-dependent clinical implications. Estimated plasma volume status (ePVS), calculated from hematocrit and body weight, may complement decongestion assessment. We evaluated the association betwe...

Sprayable EGCG-Grafted Alginate Hydrogels Embedded with Platelet Exosomes: Functional Synergy of Immunomodulation and Angiogenesis for Accelerating Burn Wound Healing

Abstract Burn wounds were often entrapped in inflammatory cascades and highly vulnerable to bacterial infection. Meanwhile, accumulated necrotic tissue and impaired vessels further aggravated local ischemia, thereby impeding the wound healing process. Herein, a sprayable hydrogel...

Sandwich structured Ω-shaped fiber optic-based sensor with dual signals for simultaneous temperature and refractive index detection

Measurements of refractive index (RI) and temperature play a vital role in a wide range of applications. Nevertheless, cross-sensitivity remains a major obstacle when RI and temperature need to be measured simultaneously. In this study, a novel sandwich structured Ω-shaped fiber...