West China Hospital of Sichuan University

Quantitative Evaluation of Cervical Spine Morphometry: Zero Echo Time MRI Versus Multislice CT

BACKGROUND: For preoperative cervical assessment, both CT and MRI are often required for bony and soft-tissue evaluation, yet CT entails radiation and MRI poorly depicts cortical bone. ZTE offers CT-like contrast in one examination, but whether it correlates with CT for quantitat...

Cross-cultural adaptation and psychometric assessment of the Chinese version of the University of Wisconsin Running Injury and Recovery Index in runners

The University of Wisconsin Running Injury and Recovery Index (UWRI) is a nine-item patient-reported outcome measure assessing self-perceived running ability following running-related injury (RRI). This study aimed to translate and cross-culturally adapt the UWRI into Chinese and...

Iatrogenic botulism induced by cosmetic injection requiring mechanical ventilation: clinical characteristics and outcomes

Introduction Cosmetic iatrogenic botulism is increasingly reported, but data on severe cases complicated by neuromuscular respiratory failure requiring mechanical ventilation remain limited. This study aims to characterize clinical features, treatment, and outcomes of such cases....

Association Between Psoriasis and Overactive Bladder Among US Adults: A Study Based on 2005–2006 and 2009–2014 National Health and Nutrition Examination Survey

BACKGROUND: Both psoriasis and overactive bladder (OAB) are considered systemic conditions that share many inflammatory or immune pathways in the pathogenesis. One previous study found patients with psoriatic arthritis (PsA) reported significantly higher bladder autonomic dysfunc...

Aminosugar-FunctionalizedMicrospheres with SuperiorBoron Selectivity and Reusability: Synthesis, Performance, and ChelationMechanism

Abstract Traditional adsorbents often face challenges such as low adsorption capacity, poor selectivity, difficulties in regeneration, and limited stability, rendering them inadequate for boron-containing wastewater treatment. In this study, glycerol methacrylate (GMA) is graft-c...

U-Shaped Association Between Left Ventricular Dimension and Mortality in Patients With Heart Failure

Importance Left ventricular structural assessment is fundamental in heart failure (HF). However, the independent prognostic value of left ventricular size beyond its association with ejection fraction remains poorly defined in real-world, large-scale populations. Objective To inv...

Assembly of Bioactive Superstructures via Metal–Phenolic Complexation for Blood Purification

ABSTRACT Hyperbilirubinemia, which stems from bilirubin accumulation caused by liver failure, can lead to jaundice, multi‐organ damage, and mortality. Hemoperfusion is the most effective detoxification approach, and its efficacy critically depends on the adsorbent system. However...

Robot‐assisted Parotidectomy: Improved Clinical and Patient‐Reported Outcomes

OBJECTIVE: To compare perioperative outcomes, postoperative safety, and patient-reported outcomes among conventional, endoscopic, and robot-assisted parotidectomy for primary benign parotid tumors. STUDY DESIGN: Retrospective comparative study. SETTING: Tertiary academic institut...

RNF213 in Panvascular Disease: A Molecular Hub Linking Genetic Susceptibility to Systemic Vasculopathy

Panvascular diseases, characterized by systemic vascular dysfunction across multiple organ systems, represent a complex interplay of genetic susceptibility and environmental triggers. Ring Finger Protein 213 (RNF213), initially identified as the principal susceptibility gene for...

Erythritol Exacerbates DSS-Induced Colitis and Influences Behavioral Responses in Mice Through Gut Microbiota and Metabolic Alterations

Excessive consumption of ultra-processed foods (UPFs) containing non-nutritive sweeteners (NNS) has been implicated in inflammatory bowel disease (IBD), yet the effects of erythritol on intestinal inflammation remain poorly understood. In this study, we assessed NNS-containing UP...

Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics

ABSTRACT Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics. Although mRNA‐based medicines have achieved clear clinical impact in vaccination, broader applications remain limited by mRNA instability, deli...

Prevalence of disease related malnutrition assessed by NRS2002, STAMP, MNA-SF, one-step and two-step GLIM at admission and discharge: A systematic review and meta-analysis.

BACKGROUND AND OBJECTIVES: Disease-related malnutrition (DRM) mandates routine screening in many nations to ensure quality care as nutritional status often deteriorates during hospitalization. This study aimed to establish tool-specific prevalence benchmarks at admission and disc...

lnc-HOTAIR inhibits MTHFR expression to regulate endothelial cell proliferation and apoptosis in aSAH-induced cerebral vasospasm

Abstract Background: Cerebral vasospasm (CVS) following aneurysmal subarachnoid hemorrhage (aSAH) is a major cause of disability and mortality, yet its pathogenesis remains incompletely understood. long non-coding RNA HOX Transcript Antisense RNA (lnc-HOTAIR) is involved in the r...

A New Technique for the Treatment of Ureteral Stricture in Patients with Solitary Kidney

OBJECTIVE: To evaluate the safety and efficacy of the Allium metal ureteral stent (AMUS) in treating ureteral stricture (US) in patients with solitary kidney (SK). PATIENTS AND METHODS: We prospectively collected clinical data from 47 SK patients with US who underwent endoscopic...

Aligning Clinical Needs and AI Capabilities: A Survey on LLMs for Medical Reasoning

Abstract Large language models (LLMs) have emerged as important tools in healthcare, showing growing potential for clinical reasoning and patient care. This survey examines recent progress in medical LLMs, focusing on reasoning applications and requirements. We present a dual-vie...

The cGAS-STING Pathway in Neuroinflammation and Neurological Disease: Mechanisms, Disease Contexts, and Periphery-to-Brain Communication

Neurodegenerative disorders involve a strong inflammatory component, yet the underlying inflammatory mechanisms may be heterogeneous across disease stage, cell type, and systemic context. A key unresolved question is how cellular and systemic stress is converted into sustained ne...

The Multi-Layered Effect of Panaxatriol Saponins in Preventing Diabetic Nephropathy in Mice

Background: Diabetic nephropathy (DN) is a common microvascular complication of diabetes and the leading cause of end-stage renal disease (ESRD). Nearly 40% of people with diabetes will develop DN, and DN accounts for 23% of ESRD cases in China. Dysfunction of the gut-kidney axis...