West China Hospital of Sichuan University

The association between perioperative oral care and adverse clinical events after complex cardiac surgery in children

Oral health is closely linked to various clinical complications, and maintaining good oral care has become one of the important interventions to reduce the risk of adverse clinical events. However, the association of oral health care with sepsis and cardiac function remains contr...

Development and validation of a nomogram for identifying the risk of oral frailty in middle-aged and elderly patients undergoing maintenance hemodialysis: a cross-sectional study

Oral frailty is a common subtype of frailty that is closely related to sarcopenia, malnutrition, disability, etc. However, it is often overlooked in maintenance hemodialysis (MHD) patients. Currently, research on oral frailty in MHD patients is still limited. This study aims to d...

Antioxidant Strategies for Inherited Retinal Degenerations in the Era of Gene Therapy

Inherited retinal degenerations (IRDs) are a genetically heterogeneous group of disorders characterized by progressive loss of photoreceptors and retinal pigment epithelium, leading to irreversible vision impairment. Although gene therapy has transformed the therapeutic outlook f...

The association between vestibular-related symptoms and depressive symptoms: a systematic review and meta-analysis

Abstract Introduction Vestibular-related symptoms are increasingly recognized as being significantly associated with depressive symptoms, yet the strength and consistency of this association remain unclear due to conflicting evidence across studies. It is also uncertain whether t...

Insights into Shared Genetic Architecture Linking Thyroid Function and Cancer

Abstract Background Growing evidence suggests a complex interplay between thyroid function and various cancers, and yet their shared genetic basis and underlying mechanisms remain unclear. Methods This study leveraged large-scale genome-wide association study (GWAS) summary for f...

Genetic links between female reproductive milestones and major depressive disorder: evidence from a common genetic factor model

Major depressive disorder (MDD) is more prevalent in women and has been linked to female reproductive timing. However, the genetic mechanisms underlying these associations remain unclear. Reproductive milestones are temporally structured and biologically interrelated, suggesting...

The association between oral health and frailty in community-dwelling older adults: a systematic review

Poor oral health is common among community-dwelling older adults and has been associated with frailty. However, evidence regarding the association between specific oral health indicators and frailty remains unclear. This systematic review aimed to summarize the current evidence o...

Patient-family concordance in end-of-life decision-making preferences among terminally ill older adults: a cross-sectional study

Family members frequently participate in end-of-life (EOL) decision-making for terminally ill older adults; however, family-member preferences for the patient may not align with the patient’s own preferences. Such discordance can complicate treatment planning and efforts to provi...

Postoperative Sleep Disturbance and Functional Recovery Following Hip Fracture Surgery: A 13‐Month Prospective Longitudinal Cohort Study

ABSTRACT Background Sleep disturbances are common after hip fracture surgery and may adversely affect postoperative recovery. However, the longitudinal course of sleep quality and its relationship with functional recovery remain poorly understood. This study aimed to characterize...

Overcoming Biological Barriers with Sononanomedicine: New Horizons in Oncology and Neurology

Abstract Biological barriers, including the tumor microenvironment and the blood–brain barrier, represent the primary bottleneck for the clinical translation of nanomedicines in oncology and neurology. Ultrasound, characterized by noninvasiveness, deep tissue penetration, and hig...

Ultrasound‐guided long peripheral catheter placement in adults with difficult intravenous access in the emergency department

Abstract Background Reliable vascular access is difficult to establish in patients with difficult intravenous access (DIVA) in the emergency department (ED). Long peripheral catheters (LPCs) offer durable peripheral access in selected patients. The feasibility, safety, and effect...

Self-efficacy of psychiatric nurses and its influencing factors in Guangdong China

Self-efficacy is a critical factor influencing quality of care, particularly for psychiatric nurses at higher occupational risk; however, research on its current status and influencing factors among the nursing population in China remains scarce. This study aimed to investigate t...

Blood nutritional and immune indices in lung cancer: a narrative review of prognostic significance, treatment response, and clinical applications

Lung cancer is the No.1 malignant tumor with the highest morbidity and mortality in the world. The prognosis of lung cancer depends not only on the tumor itself and the treatment, but also on the nutritional and immune status of the patients. Nutritional status can affect the qua...

Association between COVID-19 and exacerbation of allergic skin diseases

Coronavirus disease 2019 (COVID-19) has been linked to systemic immune dysregulation and various cutaneous manifestations, but its association with chronic allergic skin diseases, including atopic dermatitis (AD) and chronic urticaria (CU), remains unclear. This retrospective que...

Causal relationship between metabolites, cerebral volume, and amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by motor neuron degeneration. Although metabolic abnormalities have been implicated in ALS, the causal relationships between circulating metabolites and ALS remain unclear. This study ai...

LIDR-TB: large language model-integrated platform for traceable drug repurposing in tuberculosis

Tuberculosis (TB) remains a global challenge exacerbated by the ongoing emergence of drug-resistant strains. Although drug repurposing offers a cost-effective strategy to expedite therapeutic discovery, its application is impeded by the lack of unified, disease-specific framework...

MH-Penile-002: a phase II, prospective, single-arm trial of neoadjuvant anti-EGFR antibody-drug conjugate plus PD-1 inhibitor in penile cancer with challenging penile preservation or regional lymph node metastasis

Emerging evidence suggests that combinations of antibody-drug conjugates (ADCs) and immune checkpoint inhibitors (ICIs) may be effective for advanced penile squamous cell carcinoma (PSCC). These findings support the translation of this strategy into the neoadjuvant setting, offer...

Multiomics analysis reveals putative neural invasion-associated transcriptional signatures of hepatocellular carcinoma

Perineural invasion (PNI) drives tumor progression, local recurrence, and metastasis in pancreatic, prostate, and head/neck cancers. In hepatocellular carcinoma (HCC), the most common primary liver cancer, classical PNI is rarely observed, and the molecular mechanisms governing H...

miR-892b targeting CTNNB1 regulates sepsis-induced myocardial dysfunction

Numerous sepsis patients experience myocardial damage, leading to a high mortality rate of sepsis. To investigate the clinical and functional role of miR-892b in sepsis-induced myocardial dysfunction (SMD). The expression of miR-892b and CTNNB1 in clinical subjects was measured b...

Precision Medicine for Somatic Mutation-Driven Vascular Anomalies

Vascular anomalies, including proliferative vascular tumours and structural malformations, are largely driven by postzygotic somatic mutations that constitutively activate key signalling pathways, mainly the PI3K/AKT/mTOR and RAS/MAPK pathways. This molecular understanding has sh...