West China Hospital of Sichuan University

Reading trajectory analysis via multi-task gaze estimation for schizophrenia detection based on facial videos

Schizophrenia is a serious psychiatric disorder characterized by cognitive dysfunction, abnormal reading behavior, and impaired oculomotor control. To support non-invasive and low-cost screening, this study proposes a multi-scale fusion framework that detects schizophrenia from f...

Integrative Genomic and Functional Investigation of the Multi‐Layered Genetic Architecture Between Anorexia Nervosa and Bone Loss

ABSTRACT Objective Bone loss is a severe and often irreversible complication of anorexia nervosa (AN), yet the genetic mechanisms underlying this comorbidity remain underexplored. This study focuses on constructing a comprehensive genetic architecture between AN and estimated cal...

Precision Medicine for Somatic Mutation-Driven Vascular Anomalies

Vascular anomalies, including proliferative vascular tumours and structural malformations, are largely driven by postzygotic somatic mutations that constitutively activate key signalling pathways, mainly the PI3K/AKT/mTOR and RAS/MAPK pathways. This molecular understanding has sh...

Head-up lateral positioning during emergence from anaesthesia after ambulatory adenotonsillectomy in children: protocol for a multicentre randomised controlled trial

Tonsillectomy and adenoidectomy are common paediatric surgeries, with > 50% of children experiencing postoperative respiratory adverse events (PRAEs). Existing mitigation strategies have limitations, and evidence on positional interventions (e.g. lateral/semi-reclined) specifical...

Preoperative platelet-to-lymphocyte ratio and post-hepatectomy hemorrhage risk after elective hepatectomy: a single-center cohort study with exploratory calendar-time assessment of a candidate cutoff

Post-hepatectomy hemorrhage (PHH) is clinically important after liver resection, yet simple preoperative bleeding risk markers remain limited. We assessed whether preoperative platelet-to-lymphocyte ratio (PLR) was associated with PHH and derived an ROC-based threshold. In this a...

Intraoral dental caries detection based on mask-regularized vision transformer

Accurate detection of dental caries supports early intervention; however, many deep-learning approaches require dense pixel-level annotations for every image, which are costly to obtain and limit scalability. Models trained with limited supervision may also rely on spurious visua...

Digital echoes of death and dying distress among family members of intensive care unit patients: A qualitative study

Objectives To explore how ICU family members experience and articulate death and dying distress through social media narratives. Methods This study employed a qualitative design informed by the socioecological model and a constructivist epistemological perspective. Data were draw...

Clinical outcomes of bivalirudin and heparin in pediatric extracorporeal membrane oxygenation: A systematic review and meta-analysis

Managing anticoagulation during pediatric extracorporeal membrane oxygenation (ECMO) remains a persistent clinical challenge due to the narrow margin between life-threatening hemorrhage and thrombotic occlusion. While bivalirudin has gained traction as a promising alternative to...

Characteristics, treatment patterns, and outcomes of patients with transthyretin amyloidosis: a large-scale, observational, retrospective study in China (OverTTuRe China)

Abstract Background Evidence remains limited on disease journey for transthyretin (ATTR) amyloidosis in China. This study aims to analyse China data from OverTTuRe, an observational, retrospective, multi-country cohort study. Methods Data were extracted from medical records (2013...

Intraoperative blood pressure management strategies and postoperative outcomes in patients undergoing noncardiac surgery: a systematic review and meta-analysis

Abstract Background Current recommendations for intraoperative blood pressure management suggest maintaining mean arterial pressure (MAP) at ≥ 60–65 mmHg to avoid hypotension. However, controversy remains regarding whether higher or individualized MAP targets improve clinically i...

Longitudinal Study on Post‐Traumatic Stress Disorder, Anxiety, and Depression Among Medical Staff in China

ABSTRACT Background Evidence of the longitudinal relationship between anxiety, depression, and post‐traumatic stress disorder (PTSD) is not uniform. This study aimed to explore the dynamic changes, independent factors, and bidirectional predictive relationships of anxiety, depres...

Development and validation of an exosomal microRNA prognostic signature for BCLC stage A/B hepatocellular carcinoma

Hepatocellular carcinoma (HCC) exhibits remarkable prognostic heterogeneity within identical Barcelona Clinic Liver Cancer (BCLC) stages, thus requiring more precise molecular biomarkers. Exosomal microRNAs (miRNAs) are stable, non-invasive biomarkers that faithfully reflect the...

ECG theoretical knowledge and interpretation competency of arrhythmias in final-year students: a cross-sectional study

Electrocardiography (ECG) is the key method for diagnosing arrhythmias. Nurses' prompt recognition and early clinical decisions can greatly improve patient outcomes, making it essential to develop nursing students' ECG interpretation skills for arrhythmias. This study aims to ass...

Robustness of 4D-optimized intensity-modulated proton radiation therapy and proton arc radiation therapy for stereotactic arrhythmia radio-ablation against cardiorespiratory motion

Background Stereotactic arrhythmia radioablation (STAR) is an emerging noninvasive treatment for refractory ventricular tachycardia. Proton therapy offers dosimetric advantages, but pencil-beam scanning is motion-sensitive. This study used an extended cardiac-torso (XCAT)-based 4...

Development and internal validation of a nomogram for visualising multidimensional correlates of baseline suicide‑attempt history among hospitalized adolescents and young adults with mental disorders

Suicide is prevalent among adolescents and young adults with mental disorders (AYAMD). Identifying factors associated with suicide‑attempt history and characterising risk profiles are essential for targeted suicide prevention in this high‑risk inpatient population. The study incl...

Prognostic immunonutritional indices and the clinical outcome of patients with traumatic brain injury: a systematic review and meta-analysis

Adverse immunonutritional status has been increasingly recognized as a prognostic factor in patients with traumatic brain injury (TBI). This systematic review and meta-analysis evaluated the associations between immunonutritional status—defined by a low prognostic nutritional ind...

Mortality-trained MRI brain age acceleration mediates sex-specific associations between health-related phenotypes and incident dementia

Abstract Background Brain age acceleration (BAA) has emerged as a promising neuroimaging marker of brain health and neurodegeneration. However, most existing brain age models are trained to predict chronological age, which may not be the most clinically relevant target. In this s...

Local anesthetic systemic toxicity with liposomal bupivacaine: a case series and literature review

Local Anesthetic Systemic Toxicity (LAST) is an uncommon complication, with manifestations ranging from mild, non-specific neurological symptoms to severe cardiac arrest. Toxicity specifically associated with liposomal bupivacaine is even more rarely documented in the literature....

Multi-omics mapping of TIMP1-associated stromal–myeloid remodeling in autoimmune gastritis and gastric cancer

Abstract Background Autoimmune gastritis (AIG) is a chronic immune-mediated atrophic disease that can induce cancer-related epithelial remodeling, although its association with gastric adenocarcinoma depends on histological and clinical modifiers. Gastric cancer (GC) progression...

Glutaredoxin 1 facilitates colitis recovery by controlling glutathionylation and activity of STAT6 in M2 macrophages

Inflammatory bowel disease (IBD) is characterized by oxidative stress and intractable inflammation. Current therapeutic strategies are far from satisfactory because of its not fully understood pathogenesis. M2 macrophages can promote inflammation resolution and tissue repair, and...