West China Hospital of Sichuan University

Exploring a Novel Whole-Ovary Decellularization Technique for Developing Suitable Ovarian Bioscaffolds

Artificial ovary construction requires a biocompatible scaffold that mimics native extracellular matrix. This study developed a novel decellularization technique combining physical preconditioning (freeze–thaw cycle, multipoint needling, and 10% NaCl hypertonic solution) with sho...

Tail convergence in insurance financial protection: multi-layer performance among hospitalised NCD patients in Southwest China

Introduction China’s multi-layer health insurance system provides financial protection through basic insurance (Urban Employee Basic Medical Insurance [UEBMI] and Urban-Rural Resident Basic Medical Insurance [URRBMI]), catastrophic supplemental coverage, and medical assistance. U...

Sichuan dark tea with a medicine-food-homology formula synergistically alleviates alcohol-associated gut microbiota disturbance, liver steatosis and death in mice

Alcohol-associated liver disease (ALD) is a global health concern. Sichuan dark tea, a popular Chinese beverage, has been reported to have good health effects. In the study, Sichuan dark tea with a medicine-food-homology formula (TEA&MFH) has been created and evaluated for potent...

Extensive systemic thromboembolism in a patient with α-thalassemia after splenectomy: a case report

Pulmonary embolism (PE) is a common respiratory disease that require a thorough etiological workup. However, the pathophysiology of PE in thalassemia patient post-splenectomy can be easily overlooked by pulmonologists. A 38-year-old man, who had been diagnosed with α-thalassemia...

Recent Advances in Non-Viral Vectors for Gene Therapy and Gene Delivery: From Lipid Nanoparticles to Engineered Extracellular Vesicles

Gene therapy and genome editing increasingly depend on the safe, effective, and cell-selective delivery of nucleic acids and protein–nucleic acid complexes. Although viral vectors remain important for applications requiring durable gene expression, non-viral vectors offer advanta...

Serum miR-378d is associated with liver stiffness and fibrosis risk in patients with metabolic dysfunction-associated steatotic liver disease

Tissue biopsy is the gold standard for diagnosing metabolic dysfunction-associated steatohepatitis (MASH), but it is invasive and time-consuming to analyze. This paper aimed to explore the association between serum miR-378d and liver stiffness and fibrosis risk in patients with m...

Freestanding Hierarchical‐Porous BCZT Thin Films Enable Efficient Ultrasonic Energy Harvesting in Soft Tissue

ABSTRACT Excellent electromechanical properties of piezoceramic thin films facilitate ultrasonic energy harvesting in bioelectronic systems. However, most piezoceramic thin films are fragile and cannot maintain mechanical integrity under deformation, hindering their application i...

Clinical predictors of tracheobronchial tuberculosis and associated airway stenosis among patients with pulmonary tuberculosis: a study from Southwestern China

To investigate the clinical characteristics and predictors of tracheobronchial tuberculosis (TBTB) in southwestern China. This single-centre retrospective study included 1,999 patients with confirmed PTB who presented to the outpatient or inpatient departments of West China Hospi...

Metabolomic Profiling of Telomere Length: Associations with Aging-related Phenotypes and Modifiable Lifestyle Factors in Chinese Older Adults

BACKGROUND: Telomere length (TL) is a well-established biomarker of cellular senescence, yet the metabolic profile of TL and its associations with aging-related phenotypes and responses to modifiable lifestyle factors remain unclear. METHODS: TL was measured using quantitative re...

Long‐term efficacy of adjunctive cenobamate: Open‐label extension of a randomized, placebo‐controlled study in a multinational Asian population

OBJECTIVE: This study was undertaken to assess long-term efficacy, safety, and tolerability of adjunctive cenobamate in an open-label extension (OLE) of a randomized, double-blind, placebo-controlled, dose-response study (NCT04557085; YKP3089C035 [Study C035]) in Asian patients w...

Functional effects of microbial metabolites in dental caries

Dental caries is a multifactorial disease primarily driven by the metabolic activity of microorganisms within oral biofilms. The carious process begins when fermentable carbohydrates are metabolized by microbes, leading to the production of organic acids that lower the local pH a...

HIRA loss is frequent but not universal in human fumarate hydratase-deficient renal cell carcinoma and defines divergent oncogenic programs

Fumarate hydratase-deficient renal cell carcinoma (FH-dRCC) is a rare and highly aggressive malignancy driven by fumarate accumulation and widespread epigenetic reprogramming. Although Valcarcel-Jimenez et al. have demonstrated that loss of the histone chaperone Hira is a critica...

Bionic Protein Bond Constraint‐Reinforced and Enriched Multifunctional Hydrogel Coating for Invasive Medical Devices

ABSTRACT Dual‐targeted strategies addressing both infection and trauma from invasive devices are imperative. Herein, we developed a bionic protein bond constraint strategy to construct multifunctional quaternary ammonium hydrogel coatings (BEAC). Inspired by the secondary bonds s...

Hepatitis B surface antigen clearance rate with pegylated interferon-α therapy in different chronic hepatitis B virus infection populations: A systematic review and meta-analysis

BACKGROUND: Chronic hepatitis B virus (HBV) infection is an urgent public health issue, particularly in endemic regions of Asia and sub-Saharan Africa. Achieving hepatitis B surface antigen (HBsAg) clearance significantly reduces the risk of hepatocellular carcinoma. Pegylated in...

Bone Marrow‐Derived Cell Therapy Plus Core Decompression Enhanced Efficacy Compared With Core Decompression Alone in Treating Osteonecrosis of the Femoral Head: A Systematic Review and Meta‐analysis of Randomized Controlled Trials

PURPOSE: To systematically determine whether bone marrow-derived cell therapy combined with core decompression could result in better improvements in pain relief, function, and radiographic progression, higher survival of hip joints, and an equivalent rate of adverse events than...

Precision Dosing for Pediatric Growth Hormone Deficiency With Daily and Weekly Growth Hormone

ABSTRACT Pediatric growth hormone deficiency (GHD) typically requires daily injections of recombinant human growth hormone (rhGH). Long‐acting PEGylated recombinant human growth hormone (PEG‐rhGH) formulations have been developed to reduce injection frequency and improve adherenc...

Sitting Time and Physical Activity Correlate With Asthma Exacerbations in Adults: A Cross‐Sectional Study From the Australasian Severe Asthma Network

Summary Lower levels of sitting time were associated with a lower risk of severe asthma exacerbations in adults. High levels of physical activity eliminated the detrimental association of sitting time with severe asthma exacerbations in adults.

Immune-inflammatory biomarkers for in-hospital mortality risk stratification in older patients with sepsis: a multicentre leave-one-hospital-out validation study

Older adults with sepsis have high mortality, but whether circulating immune-inflammatory biomarkers improve prediction beyond routine clinical information across hospitals is uncertain. We analysed 816 patients aged ≥ 60 years from a prospectively assembled multicentre cohort at...

Minimally invasive surgery vs radical open surgery for perihilar cholangiocarcinoma: a systematic review and network meta-analysis

This network meta-analysis (NMA) analyses the latest evidence to evaluate perioperative and postoperative outcomes between minimally invasive surgery (MIS), including robot-assisted (RA) and laparoscopic (LA) approaches, versus open (OA) radical surgery for hilar cholangiocarcino...

P1.003. Causal Immune-Inflammation Mapping of the GERD-Barrett-Adenocarcinoma Cascade Identifies FGF19-HLA-DR+ T-Cell Axis Driving Esophagogastric Junction Metaplasia

Abstract Topic Benign Disease: Barrett’s Esophagus: Pathology and Pathophysiology; Non-invasive Neoplasia Background Gastroesophageal reflux disease (GERD), Barrett’s esophagus (BE), and esophageal adenocarcinoma (EAC) form a recognized pathological continuum, but the causal immu...