West China Hospital of Sichuan University

P1.080. Dynamic ctDNA Profiling Predicts Pathological Complete Response and Identifies Pseudoprogression in ESCC Receiving Neoadjuvant Immunochemotherapy

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background The integration of anti-PD-1 antibody therapy with chemotherapy has shown promising results in the neoadjuvant treatment of locally advanced esophageal squamous cell carcinoma. Conventional imaging m...

Immune-inflammatory biomarkers for in-hospital mortality risk stratification in older patients with sepsis: a multicentre leave-one-hospital-out validation study

Older adults with sepsis have high mortality, but whether circulating immune-inflammatory biomarkers improve prediction beyond routine clinical information across hospitals is uncertain. We analysed 816 patients aged ≥ 60 years from a prospectively assembled multicentre cohort at...

Minimally invasive surgery vs radical open surgery for perihilar cholangiocarcinoma: a systematic review and network meta-analysis

This network meta-analysis (NMA) analyses the latest evidence to evaluate perioperative and postoperative outcomes between minimally invasive surgery (MIS), including robot-assisted (RA) and laparoscopic (LA) approaches, versus open (OA) radical surgery for hilar cholangiocarcino...

P1.003. Causal Immune-Inflammation Mapping of the GERD-Barrett-Adenocarcinoma Cascade Identifies FGF19-HLA-DR+ T-Cell Axis Driving Esophagogastric Junction Metaplasia

Abstract Topic Benign Disease: Barrett’s Esophagus: Pathology and Pathophysiology; Non-invasive Neoplasia Background Gastroesophageal reflux disease (GERD), Barrett’s esophagus (BE), and esophageal adenocarcinoma (EAC) form a recognized pathological continuum, but the causal immu...

Rosemary extract (E392) in main Chinese foods and associated health risk

This study assessed the application of rosemary extract (E392) in foods and estimated dietary exposure in China, using a stepwise approach, encompassing theoretical maximum use, enterprise-reported usage, and product-level monitoring. Exposure assessments combined national dietar...

Sintilimab plus Bevacizumab biosimilar IBI305 and chemotherapy as a first-line treatment in advanced gastric or gastroesophageal junction adenocarcinoma (SBAGA): a single-arm, phase Ib/II study

Adding anti-PD-1 or anti-VEGF therapy to chemotherapy improves survival in patients with advanced gastric cancer, yet outcomes remain poor. This Phase Ib/II trial aimed to evaluate the efficacy and safety of combining sintilimab, the bevacizumab biosimilar IBI305, and CapeOX chem...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Bacterial etiology, antimicrobial susceptibility, and clinical outcomes in cervicofacial space infections before, during, and after the COVID-19 pandemic: a 10-year single-centre study

To investigate epidemiological trends of cervicofacial space infections in Western China, including pathogen distribution, antimicrobial resistance, and the impact of the COVID-19 pandemic on pathogen susceptibility and patient outcomes. Clinical data from 542 hospitalized patien...

A Randomized Controlled Trial of Targeted Training on Nursing Interns' Preparedness for Public Health Emergencies: A Study From West China Hospital, 2022

OBJECTIVE: To explore the effects of coronavirus-specific education and training on nursing interns' self-efficacy, stress levels, and knowledge. METHODS: 74 nursing interns were randomly allocated to either an intervention group (n = 37) or a control group (n = 37). The interven...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

EPI-Sense: an integrated hemodynamic sensing and analysis system for early pressure injury warning

Pressure injury poses a critical challenge in geriatric care. Current computer-aided diagnosis is limited by an exclusive reliance on surface texture, neglecting subcutaneous hemodynamics essential for distinguishing Reactive Hyperemia from Stage 1 PI and detecting Deep Tissue Pr...

Hepatocyte-intrinsic ER stress and NRF2 initiate primary sclerosing cholangitis, providing therapeutic insights

primary sclerosing cholangitis (PSC) is a severe liver disease that can progress to cholangiocarcinoma. Therapeutic development has been hindered by the rarity of PSC and by its poorly understood origin, which reflects incompletely defined genetic and environmental risk factors....

A deep learning model utilizing H&E-stained images for predicting HER2-low expression in breast cancer

The development and clinical application of novel HER2-targeted antibody-drug conjugates (ADCs) have significantly improved outcomes for breast cancer patients with HER2-low expression. The efficacy of such therapies critically depends on accurate assessment of HER2-low status. H...

Chinese expert consensus on extraintestinal manifestations of inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic, relapsing, inflammatory condition of the gastrointestinal tract that primarily includes Crohn's disease and ulcerative colitis. Beyond the typical gastrointestinal symptoms, IBD is frequently associated with various extraintestinal m...

Clinical study on the combined predictive value of admission neutrophil-to-lymphocyte ratio and stress hyperglycemia ratio for early neurological deterioration in acute ischemic stroke

Early neurological deterioration (END) affects short-term prognosis in acute ischemic stroke. Inflammation and stress-related glucose dysregulation may contribute to END, but their incremental predictive value remains unclear. To evaluate the associations of admission neutrophil-...

A systematic review and meta-analysis of the effects of continuous glucose monitoring compared to self-monitoring of blood glucose on glycemic control and maternal and infant outcomes in women with gestational diabetes mellitus

Abstract Background Continuous glucose monitoring (CGM) compared to self-blood glucose monitoring (SMBG) has been a controversial topic regarding glycemic control in pregnant women with gestational diabetes mellitus (GDM), as well as maternal and infant outcomes. The aim of this...

Cross-system patterns of physical, psychological and cognitive multimorbidity and 9-year all-cause mortality among middle-aged and older Chinese adults: a prospective cohort study from the China Health and Retirement Longitudinal Study

Cross-system multimorbidity—the co-occurrence of physical, psychological and cognitive disorders—is increasingly recognised as a defining feature of population ageing, yet its relationship with long-term mortality has rarely been examined at the level of specific combinations. Mo...

TyG-Biomarker discordance profiling identifies metabolically heterogeneous phenotypes with divergent cardiovascular and diabetes risk: metabolomic characterization from the UK biobank

The triglyceride-glucose (TyG) index is a widely used surrogate of insulin resistance, yet it captures only a narrow slice of the broader cardiometabolic dysregulation associated with metabolic dysfunction. Whether individuals with equivalent TyG values harbour meaningfully disti...

Social determinants of health and lifestyle in the progression of degenerative bone and joint diseases: a prospective multi-state analysis

Abstract Aims The role of social determinants of health (SDOH) in the progression of degenerative bone and joint diseases (DBJDs) - from initial onset to multimorbidity and mortality - remains unclear. We aimed to assess the associations of SDOH with DBJDs progression, examine th...

Engineered desialylated platelet membrane camouflaged liposomes for the regulation of kupffer cells and hepatic stellate cells in treatment of liver fibrosis

The intercellular crosstalk and reciprocal activation between Kupffer cells (KCs) and hepatic stellate cells (HSCs) are critical drivers of liver fibrosis progression. Nonetheless, the co-regulation of KCs and HSCs is hindered by their distinct anatomical locations and the pathol...