West China Hospital of Sichuan University

Ectopic thyroid tissue accompanied by distinct blood supply and lymphoid tissue within the carotid sheath - a case report

Rationale: Ectopic thyroid tissue (ETT) is not extremely rare, but it may be overlooked in clinical practice because of its frequently asymptomatic presentation, lack of urgency for diagnosis, and limitations in diagnostic techniques. We report a case of ETT within the carotid sh...

BIRC3 facilitates osteogenic differentiation of bone marrow mesenchymal stem cells via NGFR/β-catenin signalling axis

Aims: Osteoporosis primarily results from age-related declines in bone marrow mesenchymal stem cell (BMSC) differentiation into osteoblasts; however, the regulatory mechanisms remain unclear. Methods: Integrated analysis of Gene Expression Omnibus (GEO) and RNA sequencing (RNA-se...

Next-generation natural killer cell therapy: bench to bedside and beyond

Natural killer (NK) cells have emerged as central players in cancer immunotherapy, progressing from basic discovery to clinically validated platforms over five decades. This review synthesizes the evolving understanding of NK cell biology, including subset heterogeneity, epigenet...

Ocular Gene Therapy in China: Technological Framework, Clinical Translation, and Future Perspectives

The eye is well suited to gene therapy because of its compartmentalized anatomy, accessibility for local delivery, and capacity for longitudinal assessment. In China, ocular gene therapy is undergoing rapid clinical translation, with expanding innovation in vector engineering, de...

The Application Potential and Future Challenges of Plant-Derived Exosome-like Nanoparticles in the Treatment of Liver Diseases

Liver disease is a serious global health challenge, with high morbidity and mortality that put significant socioeconomic stress on society. Despite therapeutic advances, current regimens have been limited by rapid drug resistance and insufficient targeting accuracy, and there is...

Development of a Potent and Isoform-Selective HDAC11 Inhibitor with Anti-Tumor Efficacy against Non-Small Cell Lung Cancer

Abstract Targeting histone deacetylase 11 (HDAC11) represents a promising therapeutic strategy, yet developing selective inhibitors for solid tumors remains a formidable challenge. Herein, we describe the rational lead optimization of a novel series of indole-based hydroxamic aci...

Programmable Temperature‐Capped Dressing for Enhanced Wound Healing, Bacterial Clearance, and Inflammatory Modulation

ABSTRACT Reconciling efficient bacterial eradication with tissue safety remains a challenge in photothermal therapy (PTT) because of open‐loop thermal actuation. Herein, we propose a detachable bilayer hydrogel dressing comprising a poly(N‐isopropylacrylamide) (PNIPAM)‐based prot...

Evaluation of Rare MCOLN1 Variants in a Large Cohort of α‐Synucleinopathies

Note: Genomic position was based on GRCh37.Variants were classified according to the 2015 American College of Medical Genetics and Genomics (ACMG) and Association for Molecular Pathology (AMP) joint consensus guidelines, with P indicating that the variant is pathogenic.Function p...

Enhanced Energy Storage Performance of High‐Temperature Dielectric Films by Internally Constructing Oriented Microfibril Structure

ABSTRACT High‐temperature dielectric films are essential components for capacitive energy storage in severe environments, ranging from hybrid electric vehicles to power systems. However, the surge in leakage current at elevated temperatures leads to a dramatic decrease in dischar...

Association between estimated plasma volume status and 90-day outcomes in patients with acute-on-chronic liver failure treated with artificial liver support system: a retrospective cohort study

Water and electrolyte imbalance is a common complication of liver failure. Estimated plasma volume status (ePVS) has shown significant prognostic value in conditions characterized by fluid redistribution and inflammation; however, its association with clinical outcomes in acute-o...

Differential associations of aging attitude risk with depression, anxiety, and suicide-related risk among older Chinese adults: a network analysis and GGMNIRA-based simulated intervention study

Attitudes toward aging reflect how individuals understand and appraise their own aging process and may be closely associated with mental health in later life. Previous studies have primarily examined associations of attitudes toward aging with depression, anxiety, and suicide-rel...

Intratumoral microbiota: spatiotemporal dynamics, microenvironmental immune reprogramming, and immunotherapeutic implications

The discovery of intratumoral microbiota has challenged the traditional view of tumors as sterile environments and revealed a previously unrecognized layer of complexity within the tumor microenvironment (TME). Accumulating evidence indicates that microorganisms residing in tumor...

Acupuncture and Moxibustion for Neck Pain: A Clinical Practice Guideline

ABSTRACT Background Neck pain (NP) is a leading cause of disability worldwide. Pharmacological treatments often provide limited benefits and may be associated with adverse effects, highlighting the need for effective non‐pharmacological options. Aim To develop evidence‐based reco...

Advanced detection of carcinogenic heterocyclic amines in meats: an overview of analytical and nanotechnology methods

Abstract Despite extensive research on the formation and health risks of heterocyclic amines (HAs) in cooked meats, there is a gap in comparative analysis of advanced detection methods, particularly juxtaposing classical analytical techniques against emerging nanotechnology‐based...

Staged Orthoplastic Soft-Tissue Reconstruction of Complex Tibial Fracture-Related Infection Using a Chimeric Anterolateral Thigh Free Flap After Failed Soleus Muscle Flap: A Case Report

A complex tibial fracture-related infection (FRI) after local-flap failure may require staged source control, dead-space management, and vascularized soft-tissue reconstruction. A 60-year-old man with type 2 diabetes developed FRI after an industrial injury causing a localized in...

Delayed deterioration after surgical treatment of a spinal dural arteriovenous fistula detected by three spinal angiographies: Case report

Spinal dural arteriovenous fistulas (DAVFs) are the most common subtype of spinal arteriovenous malformations, and they often cause progressive myelopathy. Early detection and intervention are critical to preventing irreversible neurological deficits. Selective spinal angiography...

Taking a clinical history in adolescents and adults presenting with seizures or epilepsy

Abstract Despite advances in EEG, neuroimaging, and other diagnostic technologies, a carefully obtained clinical history remains the cornerstone of diagnosis, classification, and treatment planning. However, structured guidance on history‐taking that integrates state‐of‐the‐art e...

Machine Learning in Amyloidogenic Polypeptide Research: From Sequence Prediction to Drug Discovery

Abstract Over the past decade, machine learning (ML) has established a transformative paradigm for investigating amyloidogenic polypeptides. Characterized by their propensity to form ordered, β-sheet-rich fibrillar aggregates, these polypeptides are centrally implicated in the pa...

Gut microbiota‐derived tryptophan metabolite attenuates calcium oxalate nephropathy by suppressing renal tubular cell apoptosis through the AhR – SOCS3 – STAT1 axis

Calcium oxalate (CaOx) nephropathy is a highly prevalent urological disease worldwide. Gut microbiota dysbiosis and host metabolic dysregulation are recognized as pivotal drivers in disease pathogenesis, yet the underlying mechanisms remain incompletely understood. In this study,...

The impact of tranexamic acid on graft function in liver transplantation: A randomised controlled trial

Tranexamic acid (TXA) has been reported to reduce transfusion requirements in liver transplantation (LT). However, clinical evidence regarding the impact of TXA on graft function and other outcomes in liver transplant recipients remains limited. This study aimed to evaluate the e...