Washington University in St. Louis

Interventions to Reduce Financial Toxicity of Childhood, Adolescent, and Young Adult Cancer Survivors: A Scoping Review

Financial toxicity (FT) worsens health outcomes and quality of life for childhood, adolescent, and young adult (CAYA) cancer survivors. This scoping review examines interventions designed to alleviate FT among CAYA cancer survivors and identifies the levels of influence within th...

Sexually Dimorphic Role of Estrogen Receptor α in Preserving Right Ventricular Endothelial Integrity

Abstract Right ventricular (RV) function and adaptation to afterload increase determine survival in pulmonary hypertension (PH). RV adaptation in PH is sexually dimorphic and more preserved in females, mediated by protective estrogen receptor α (ERα) signaling in cardiomyocytes....

Rapid Adsorption−Desorption in Direct Air Capture Using 3D-Printed Amine Adsorbents with Electromagnetic Induction Heating

Abstract Direct air capture (DAC) is a promising strategy to address climate change and achieve carbon neutrality goals. The development of an adsorbent material with a high capacity, low pressure drop, and short regeneration period is necessary for high-performance DAC. Here, we...

Privacy-Preserving Transfer Learning for Community Detection using Locally Distributed Multiple Networks

Modern applications increasingly involve highly sensitive network data, where raw edges cannot be shared due to privacy constraints. We propose \texttt{TransNet}, a new spectral clustering-based transfer learning framework that improves community detection on a \emph{target netwo...

Why translation is not enough and how functional language use can improve cultural adaptation in bilingual implementation settings

Despite widespread bilingualism, most intervention adaptation efforts remain grounded in monolingual assumptions. This approach poorly reflects how bilingual communication functions. Research in sociolinguistics and psycholinguistics shows that bilingual speakers do not “turn off...

Thioamide‐Enabled Anodic N‐Centered Radical Cyclizations

An anodic cyclization leading to the 6‐membered ring, bisamine‐heterocyclic core of the chrysosporazine family of efflux inhibitors, has been accomplished. The reactions proceed through a N‐based radical intermediate that is derived from the oxidation of a thioamide anion and ben...

Tibialis Cranialis Extrafusal and Intrafusal Myofibers and Muscle Spindle Pathology in Canine Degenerative Myelopathy

Canine degenerative myelopathy (DM) is a progressive, adult-onset neurodegenerative disease, with similarities to superoxide dismutase 1 (SOD1)-associated ALS. Clinical signs of DM begin with asymmetric pelvic limb general proprioceptive ataxia and spastic paresis that progresses...

Fibroblast growth factor receptor signaling in maturing osteoblasts controls cell-matrix interactions critical for osteocyte survival

Abstract The terminal differentiation of osteoblasts into osteocytes, the most abundant cell type in cortical bone, is critical for skeletal homeostasis. Osteocyte loss is a hallmark of bone aging and fragility, yet the mechanisms regulating osteocyte formation and survival are p...

Author reply to Rothschild, Bruce (Tele‐rheumatology. The risk related to diagnostic and therapeutic decisions based on purposely incomplete, unvetted examination reports)

Disclosure Form Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Instrumental activities of daily living in older adults with epilepsy: A cross‐sectional and longitudinal multicenter study

OBJECTIVE: Instrumental activities of daily living (IADLs) represent a critical but understudied measure of day-to-day function in people with epilepsy (PWE). In the multicenter Brain Aging and Cognition in Epilepsy (BrACE) study of PWE ≥55 years of age, we examined the proportio...

Selective activation of nerve fiber subpopulations with intrafascicular stimulation

Background: Peripheral nerve stimulation (PNS) is most effective when specific nerve fiber subpopulations are activated, while minimizing off-target activation, which may cause undesirable side effects. This selectivity depends primarily on electrode design and charge delivery. W...

A Modular Tecton Matrix for Mechanosynthesis of Large‐Pore Hydrogen‐Bonded Organic Frameworks With Programmable Pore Environments

ABSTRACT Hydrogen‐bonded organic frameworks (HOFs) offer versatile porous architectures, yet predictable pore expansion via tecton extension remains challenging because framework assembly is highly sensitive to solvent‐mediated crystallization. Here, we establish a mechanosynthes...

Planning a Clinical Practice Guideline Revision for a Core Set of Outcome Measures in Adults Undergoing Neurologic Physical Therapy, Part 1: Assessing Dissemination and Scholarly Uptake

ABSTRACT Introduction Clinical Practice Guidelines (CPGs) facilitate evidence‐based decision‐making and standardising care, yet their dissemination and scholarly uptake vary widely. The Core Set of Outcome Measures for Adults With Neurologic Conditions Undergoing Rehabilitation C...

Strategies to Promote HIV Self-Testing and Long-Acting Injectable PrEP Among Ghanaian Youth: Results from the Y-FIT GH National Crowdsourcing Open Call

Abstract Crowdsourcing is a participatory problem-solving approach that engages a large and diverse group of individuals to generate ideas or solutions. In HIV prevention, it provides a structured mechanism for involving youth in shaping intervention strategies. The Innovative To...

Online Cannabis Marketing Practices and Regulatory Compliance: A Surveillance Study Across 5 US Cities in States with Different Cannabis Regulations

Background: Cannabis marketing and regulation have rapidly evolved. This study examined online cannabis marketing across different regulatory contexts. Methods: In 2022 and 2025, we assessed cannabis retailer websites from 5 US cities: Denver, Colorado; Seattle, Washington; Portl...

A Multicenter Prospective, Observational Study of Observation Versus Colectomy in Recurrent Diverticulitis

BACKGROUND: Understanding changes in quality of life that occur with colectomy is critical to decision-making in management of recurrent diverticulitis. We hypothesized that patients choosing colectomy at surgical consultation would report better disease-specific quality of life...

TPOP: A Laser-Based, Peroxide-Free Approach for Microsecond Hydroxyl Radical Protein Footprinting in Water

Abstract We introduce here a novel protein footprinting approach termed “two-photon oxidation of proteins (TPOP)”. This method employs a nanosecond, high-power, 248 nm excimer laser to induce two-photon absorption in both water and aromatic amino acids within proteins. The two-ph...

Ancient DNA reveals early use of melons in China’s Song dynasty

Abstract Melon ( Cucumis melo L.) domestication is thought to have occurred independently once in Northeast Africa and twice in India, but archaeobotanical seed remains point to a possible additional domestication in China. Because Cucumis seeds are difficult to diagnose morpholo...

Unfolded protein response signaling promotes myeloid cell production and cooperates with oncogenic mutation

Abstract Unfolded protein response (UPR) promotes protein homeostasis under endoplasmic reticulum stress. UPR signaling has numerous functions in metabolism, cancer, immunology, and neurodegenerative diseases. Recent studies also showed that UPR signaling has important roles in h...

Factors Influencing Caregiver Anxiety in the Pediatric Emergency Department

OBJECTIVES: This study identified demographic and experiential factors associated with caregiver anxiety in a pediatric emergency department (PED). METHODS: We conducted a cross-sectional survey of caregivers for children brought to our PED. Participant anxiety was assessed with...