Washington University in St. Louis

Acquired resistance to the RAS(ON) multi-selective inhibitor daraxonrasib guides rational combination therapy strategies in pancreatic cancer

Abstract Daraxonrasib is an orally bioavailable RAS(ON) multi-selective tri-complex inhibitor of the oncogenic mutant and wild-type variants of N, H and KRAS. We previously reported encouraging efficacy in a phase 1/2 clinical trial evaluating daraxonrasib monotherapy at clinical...

Traumatic Catheter Removal‐ At‐Risk Populations, Outcomes and Prevention: A Retrospective Medical Record Review

AIMS: Traumatic catheter removal (TCR) occurs when a urinary catheter is removed with the balloon inflated, causing urethral injury. We aim to identify cases of TCR, determine at-risk populations and describe outcomes and interventions. DESIGN: Retrospective medical record review...

Real-World Experience of Hepatitis C Treatment With Glecaprevir-Pibrentasvir During Pregnancy.

Guidelines endorse antenatal hepatitis C virus treatment following shared decision making. No clinical trial or real-world data exist for glecaprevir-pibrentasvir (GLE/PIB). We report our experience with prenatal GLE/PIB in 14 patients. Ten patients completed treatment; all achie...

Individualized hybrid electroconvulsive therapy (i-HECT) shows rapid anti-depressant effect in young patients with depression

Abstract Background For young patients with depression, electroconvulsive therapy (ECT) is highly effective but causes acute cognitive side effects. We designed a new individualized hybrid electroconvulsive therapy (i-HECT) combines ECT with low-charge electrotherapy (LCE) and in...

Bootstrapping Generalization Error Bounds for Time Series

Abstract We consider the problem of constructing confidence intervals for the risk of forecasting the future of a stationary, ergodic stochastic process, using a model estimated from the past of the process. We show that a bootstrap procedure provides valid confidence intervals f...

Vasospasm and Delayed Cerebral Ischemia in Aneurysmal Rupture with Intracerebral Hemorrhage With and Without Subarachnoid Hemorrhage

BACKGROUND: The risk of vasospasm and delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH) is well characterized. However, the risk of these complications in cases of aneurysmal rupture causing intracerebral hemorrhage is less clear. Here, we characteriz...

Disability-Related Differences in Substance Use Among U.S. Young Adults

BACKGROUND: People with (vs without) disabilities may be at greater risk for substance use, but limited research has explored the use of various substances among people with disabilities. This study examined differences in substance use among U.S. young adults with versus without...

Cognitive-behavioral suicide prevention for psychosis in community mental health: A pilot randomized clinical trial

Adults with schizophrenia spectrum disorders (SSDs) have substantially elevated suicide risk, yet few suicide prevention interventions have been developed or tested for this population. The effectiveness of Cognitive-Behavioral Suicide Prevention for psychosis (CBSPp) in US commu...

Robust Inference With Ghostknockoffs in Genome‐Wide Association Studies With Sample Relatedness

ABSTRACT Genome‐wide association studies (GWASs) have been extensively adopted to depict the underlying genetic architecture of complex traits. Recent studies show that knockoff‐based methods can identify variants with unique, potentially causal effects on phenotypes. However, th...

Fully tunable on-chip meta-generator for multidimensional Poincaré sphere mapping

Abstract The angular momentum of light can be elegantly mapped onto high-order Poincaré spheres, providing a powerful framework for describing structured light beams. Such beams have shown extraordinary potential across diverse applications, including high-capacity optical commun...

Senescent peripheral fibroblasts initiate chemotherapy-induced peripheral neuropathy

All raw data files to support manuscript.

The Plasmodium heme detoxification protein functions in mitochondrial protein synthesis

Abstract Malaria blood-stage parasites digest ~80% of host cell hemoglobin within a degradative vacuole, releasing heme that is detoxified by sequestration into hemozoin crystals. Although essential for survival and a validated drug target, the mechanisms of heme biomineralizatio...

Towards scalable AI-assisted pre-bunking of election misinformation: evidence from a pre-registered US panel experiment

Abstract We present a scalable artificial intelligence (AI)-assisted framework for rapidly generating ‘pre-bunking’ articles against election misinformation. Our approach uses a stable template structure that, once finalized through human review, can be quickly adapted to counter...

Patterns of Autonomous and Conditional Neural Specification for the Brain and Ventral Nerve Cord in Annelida

ABSTRACT Evolution of central nervous systems is a long‐debated topic. Similar mechanisms of conditional neural specification linked to dorsal‐ventral (D–V) axis formation have been used to support homology across several taxa. We tested for autonomous versus conditional neural s...

A compendium of next-generation patient-derived models for diverse cancers

Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...

Metal–Organic Framework‐Preserved Thermostable Microneedle Patch for Minimally Invasive Detection and Monitoring of Kidney Dysfunction

Early and decentralized biomarker detection and monitoring is essential for timely diagnosis and intervention, particularly in kidney disorders that often progress asymptomatically until irreversible damage has occurred. Here, we present a thermally resilient metal-organic framew...

“What Was College Made For?” Exploring College Students’ Civic Engagement Outcomes by College Major

Abstract In light of political discourse around return-on-investment (ROI) of obtaining postsecondary degrees, one often overlooked outcome of a college education is students’ development of their civic engagement. We were concerned about whether specific degree programs targeted...

The Digital Mental Health Study assessed feasibility of large-scale digital sensing for depression and anxiety

Abstract Data passively obtained from smartphones and wearables can provide nearly continuous objective information that enables quantification of states and traits across broad physiological, behavioral, and emotional domains impacted in mental health conditions, including depre...

The Impact of Septorhinoplasty on Work Productivity and Activity Impairment: A Multi‐Institutional, Prospective Cohort

OBJECTIVE: To evaluate the effect of septorhinoplasty on work productivity and activity impairment. STUDY DESIGN: Prospective cohort. SETTING: Four tertiary institutions. METHODS: Adults undergoing septorhinoplasty were administered surveys preoperatively and 3 to 8 months postop...

Adipose Tissue Palmitoylation Cycling Mediates Insulin Resistance and Preservation of β-Cell Function in Mice

Excess adiposity is associated with insulin resistance and pancreatic β-cell dysfunction. We show that palmitoylation cycling in white adipose tissue (WAT) balances insulin sensitivity and insulin secretion. WAT and brown adipose tissue (BAT) ablation of acyl-protein thioesterase...