Washington University in St. Louis

Mapping pediatric cardiac troponin testing worldwide: results from the IFCC survey on emerging applications, standardization needs and access

OBJECTIVES: Limited guidance on the use and interpretation of cardiac troponin (cTn) testing in pediatric populations has restricted its broader adoption, despite the significant burden of congenital and acquired cardiac conditions in children. This survey aimed to evaluate globa...

Private Languages

Strategic communication often relies on anchors observed by the sender but not by the receiver. An analyst may report against a proprietary valuation model, an auditor against an internal score, a manager against an accounting estimate, or an institution against its own standard....

Private Languages

Strategic communication often relies on anchors observed by the sender but not by the receiver. An analyst may report against a proprietary valuation model, an auditor against an internal score, a manager against an accounting estimate, or an institution against its own standard....

Cryptic NLRP3 Mosaicism Uncovered by Deep Sequencing in Muckle-Wells Syndrome: A Case Report

Background Muckle-Wells syndrome is part of the cryopyrin-associated periodic syndrome (CAPS) family, a group of rare autoinflammatory conditions caused by gain-of-function variants in the NLRP3 gene, leading to uncontrolled activation of the inflammasome and excessive IL-1β rele...

Mechanisms of Association of Maternal Education and Intent to Vaccinate Children Against COVID-19

BACKGROUND Although higher maternal education is positively associated with many child health–promoting practices, it is more complicated for child vaccination, and the explanatory mechanisms remain unclear. We aimed to examine mechanisms underlying the association of maternal ed...

Red Blood Cell Distribution Width Is Associated With Functional Outcomes Following Surgery for Hip Fracture

BACKGROUND: Elevated red blood cell distribution width (RDW) is increasingly found to be associated with adverse health outcomes in older adults. We leveraged a randomized clinical trial that was investigating responses to supervised exercise (EX) with or without a topical testos...

Implementation strategies and adjunctive interventions for HIV testing and linkage-to-care in the United States: a systematic review

Ending the HIV Epidemic in the United States depends on expanding HIV testing and rapidly linking people to care. However, methods to improve testing and linkage-to-care are inconsistently described and often conflate health system–level implementation strategies with recipient-d...

Outcomes in patients with endophthalmitis and no light perception vision initially treated with intravitreal antibiotics

Abstract Background Management of endophthalmitis presenting with NLP (no light perception) vision remains poorly defined, with limited evidence guiding treatment decisions. We aim to investigate whether treatment with intravitreal antibiotics reduces the rate of enucleation or e...