Washington University in St. Louis

Join the Ambassadors Coordination Group to Strengthen Community Connections for Global Impact

This poster introduces the Research Data Alliance (RDA) Ambassadors Coordination Group (ACG) and invites RDA members from all regions and disciplines to join. Ambassadors connect communities, promote RDA outputs and FAIR data practices, and mentor new members. The group works thr...

Disability Representation in Social and Personality Psychology Research: A State-of-the-Art Review

We conducted a systematic state-of-the-art review examining disability representation of three flagship social and personality psychology journals between 2017 and 2022. First, we examined the 2,343 articles published in that time frame and found that 192 (8.19%) of them used at...

Development and feasibility testing of an electronic medical record intervention to improve emergency department discharge communication for patients with uncertainty: a pilot study

Abstract Background A significant proportion of patients leave the emergency department (ED) without a definitive diagnosis, leading to challenges in the post-discharge period due to diagnostic uncertainty. Building on previous work aimed at improving discharge communication, we...

Antiferroelectric hafnia down to the 2D limit

Antiferroelectricity is a material property characterized by alternating electric dipoles spontaneously ordered in antiparallel directions. Antiferroelectrics are promising for energy storage, solid-state cooling, and memory technologies; however, these materials are scarce, and...

Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency

Abstract Medulloblastoma is a biologically heterogeneous childhood cerebellar tumor harboring frequent chromatin-modifying gene alterations. How these alterations promote transcriptional programs governing malignancy remains poorly defined. To address this knowledge gap, we evalu...

The Punitive Dimension of Presidential Particularism

Existing accounts of presidential particularism emphasize the targeted distribution of benefits to electorally valuable constituencies. This research note demonstrates that presidential particularism can also operate punitively, through the selective imposition of costs on consti...

Prevalence and trends in recent alcohol consumption by cancer history and cancer type in a nationally representative sample of U.S. adults

Abstract Purpose Alcohol consumption increases the risk of several cancer types. Using nationally representative data, we aimed to 1) quantify trends in alcohol consumption by cancer history and 2) estimate prevalence differences in alcohol consumption comparing individuals with...

Trends in Regionalization of Pediatric Inpatient and Critical Care by Medical Complexity

BACKGROUND AND OBJECTIVES: Pediatric inpatient and critical care services are increasingly regionalizing: shifting from smaller hospitals to larger specialty centers. Children with medical complexity (CMC) and with technology dependence (TD) account for a disproportionate share o...

Black Women’s Health Futures: Speculative Method as Structural Intervention

Public health research predominantly works in the present tense. It documents the disparities that structural racism and gendered racism produce and projects them forward, modeling futures as extrapolations of present harm. For Black women, positioned at the intersection of racis...

Effect of In-line Clinical Decision Support to Improve Accuracy of American Society of Anesthesiologists Physical Status Documentation: A Two Center Evaluation of a Quality Intervention

Background: American Society of Anesthesiologists Physical Status (ASA PS) classification is a widely used ordinal scale that captures comorbidity burden but has significant inter-rater variability. Previous efforts to enhance ASA PS documentation with Clinical Decision Support (...

Actionable genetic landscape and dynamics in circulating DNA from 12,827 patients with metastatic breast cancer

Abstract Plasma cell-free DNA (cfDNA) is a sensitive, noninvasive tool for monitoring the genomic landscape, heterogeneity, and evolution of cancer, aggregating genetic information from multiple metastatic sites. Here, we study 15,564 cfDNA samples from 12,827 patients with metas...

Vitamin D in coronary heart disease: a Mendelian randomization meta-analysis of data stratified by 25(OH)D levels

Maria Fusaro, Pasquale Perrone Filardi, Gianfranco Sinagra, Maria Luisa Brandi, Maurizio Gallieni, Jean-Yves Reginster, Eugene McCloskey, Etienne Cavalier,

Clonal Hematopoiesis of Indeterminate Potential Proteomic Risk Score for Predicting Clinical Outcome in Patients With Heart Failure With Preserved Ejection Fraction

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) is common in heart failure with preserved ejection fraction (HFpEF). However, the proteomic signatures linked to CHIP driver mutations and their prognostic implications in HFpEF remain poorly defined. We aimed to...

Periacetabular Osteotomy and Combined Open Femoral Head-Neck Junction Osteochondroplasty: A Concise Follow-up of a Previous Report at a Mean 10-Year Follow-up

Background: Hip dysplasia is a well-established cause of hip dysfunction and secondary osteoarthritis in young adults. Periacetabular osteotomy (PAO) is a common surgical treatment for symptomatic acetabular dysplasia. Recent awareness of concomitant impingement in dysplastic hip...

Reliability of computational versus noncomputational metrics of working memory and episodic memory in serious mental illness.

= 76). These participants were tested in working memory and episodic memory paradigms. We applied a computational model that yielded parameters corresponding to memory storage capacity, memory precision, and the rate of attention lapses. We also examined a noncomputational metric...

Local equilibrium geometry at active-set boundaries in optimization-based feedback systems

We study local equilibrium changes in smooth control-affine systems closed by minimum-deviation quadratic-program feedback. At a regular active-set boundary, the optimizer and the closed-loop vector field remain continuous, while the closed-loop Jacobian acquires an explicit rank...

Examining social and biological determinants of health driving opioid and stimulant involved deaths among black people in St. Louis, MO

The fourth wave of the opioid crisis—characterized by co-use of opioids (namely illicit fentanyl) and stimulants– has exacerbated the risk of fatal overdose. The effects of co-involved opioid and stimulant use have been particularly stark among Black people in the U.S., who demon...

Transitioning primary care from residents to attendings – an approach to address challenges in care during the academic year transition

Internal medicine residents provide primary care to a panel of patients. Annually, 600,000 patients are assigned new resident primary care physicians (rPCPs) when their current rPCP graduates. At our academic resident and faculty primary care practice, all rPCPs review their pane...

Toward actionable biomarkers in psychiatry: a collaborative roadmap for precision clinical trials. An ACNP position paper

Abstract Psychiatric drug development remains constrained by diagnostic heterogeneity, insufficient and inconsistent drug response, high placebo response rates, and the absence of validated biomarkers that can reliably guide patient stratification, trial design, and regulatory de...

How we talk and teach in the operating room: using live operative recordings to evaluate resident autonomy

Abstract Purpose Intraoperative dialogue between faculty and trainees is rich with feedback; however surgical training still relies primarily on delayed, subjective post-procedural written evaluations. We sought to capture and analyze minute-to-minute intraoperative communication...