Institution
Washington University in St. Louis
Recent research
- Health & MedicineOpen access
Exercise is widely recognized for its cardiovascular benefits; however, its safety and role in patients with thoracic aortic aneurysms (TAAs) remains complex due to its distinctive biomechanical vulnerabilities. Fundamentally different from abdominal aortic aneurysms, TAAs develo...
- BiologyOpen access
Abstract Cognitive aging is often associated with increased Stroop interference, but it remains unclear whether this reflects a broad decline in inhibitory control or selective impairments in specific conflict-resolution mechanisms. The present study examined age-related differen...
- Health & Medicine
Toward clinically actionable lupus biomarkers: a roadmap for research, validation, and translation
Abstract Despite advances in lupus biomarker research, clinical translation has remained limited, leading to delayed diagnosis, imprecise disease monitoring, and trial-and-error treatment approaches. This roadmap, developed by the Lupus Research Alliance’s Biomarker Roadmap Commi...
- Society & Economics
Objective Psychological resilience may support adaptation to physical limitations, but definitions and measures vary. This scoping review examined how psychological resilience has been conceptualized and measured among older adults, focusing on studies addressing physical limitat...
- Health & Medicine
Background: For patients with open physes approaching skeletal maturity, transphyseal anterior cruciate ligament reconstruction (ACLR) with soft tissue autograft and metaphyseal fixation is often preferred. Although iatrogenic physeal injury is rare, growth disturbances have been...
- Health & MedicineOpen access
Aberrant one-carbon metabolism and ancestral genetics underlie edematous severe acute malnutrition
Edematous severe childhood malnutrition is distinct from the non-edematous form of malnutrition and remains a major cause of under-five mortality. Its etiology remains unclear, although aberrant one-carbon metabolism has emerged as a potential contributor. Here, we assess genetic...
- Health & MedicineOpen access
Abstract We surveyed clinicians about efforts to initiate hepatitis C antivirals during hospitalization or at discharge. We identified 29 hospitals in the United States working on such initiatives, with most efforts being less than 3 years old. Further initiative expansion is hin...
- Health & MedicineOpen access
Stathmin 1 is a cytoplasmic phosphoprotein that regulates microtubule dynamics. Stathmin 1 expression is a feature of proliferating cells, and it is overexpressed in many cancers, including leukemias. In contrast to its roles in proliferating cells, considerably less is known of...
- Health & MedicineOpen access
Abstract Background Irreversible electroporation (IRE) is used in selected patients with Stage III pancreatic ductal adenocarcinoma (PDAC), but its association with survival relative to standard-of-care (SOC) therapy remains uncertain. Methods This multicenter observational study...
- Health & Medicine
Study Design. Retrospective analysis of a prospective multicenter operative cervical deformity (CD) database. Objective. To determine whether T1 slope (T1S) and C2 slope (C2S) together identify distinct CD phenotypes: cervical-only versus global sagittal deformity, and to compare...
- Biology
Microglial dysfunction is increasingly implicated in Alzheimer’s disease (AD) pathogenesis, with loss-of-function variants in the microglial receptor TREM2 as major risk factors for late-onset AD. We report VG-3927, an oral, CNS-penetrant small-molecule TREM2 agonist that engages...
- Engineering & TechnologyOpen access
Twist-Induced Out-of-Plane Ferroelectricity in Bilayer Hafnia
Abstract Ferroelectric HfO2 is a promising candidate for next-generation memory devices due to its CMOS compatibility and ability to retain polarization at nanometer scales. However, the polar orthorhombic phase responsible for ferroelectricity is metastable and requires extrinsi...
- Health & Medicine
Global Incidence of All-Cause Dementia
Importance Global dementia incidence estimates are limited by underrepresentation of low- and middle-income countries and heterogeneous analytic methods. Due to these limitations, true understanding of the global dementia landscape remains incomplete. Objective To identify dement...
- Health & MedicineOpen access
Complete data and analysis package for a systematic review and meta-analysis of peripheral immune biomarkers in bipolar disorder, focused on the interleukin-23/T-helper-17 axis (PROSPERO CRD420261434475). The deposit contains the extraction layer (one row per reported group stati...
- Health & MedicineOpen access
Abstract Tau is traditionally known for its role in microtubule stabilisation, with its pathological aggregation central to tauopathies such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Recent evidence suggests that tau also plays important nuclear and nucleolar...
- BiologyOpen access
Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...
- Health & Medicine
Date presented: April 24, 2026 Primary Author and Speaker: Alaina Randerson, alainaranderson@gmail.com
- Health & Medicine
Systematic Review of 3D Printing as a Medium for Assistive Technology in Rehabilitation
Date presented: April 23, 2026 Primary Author and Speaker: William E. Janes, janesw@health.missouri.edu
- Society & EconomicsOpen access
Background Depression is a leading cause of disability worldwide, associated with reduced quality-of-life and significant economic costs. While NICE has recommended first-line pharmacological, psychological and physical interventions for adults with less severe (subthreshold/mild...
- Health & Medicine
Date presented: April 24, 2026 Primary Author and Speaker: Szu-Wei Chen, szuwei.chen@siu.edu