Utrecht University

Evaluating Concerning Behavior of Fixated Individuals

Fixated individuals who send repeated concerning communications to public figures pose a significant challenge, particularly when such communications escalate to approach or violence. The present study examined associations between three sources of threat assessment information-m...

Global hyper-resolution modeling of historical and future groundwater dynamics

Abstract. The sustainable management of global groundwater resources is a key societal challenge and is central to the Sustainable Development Goals. The localized dynamics of groundwater abstraction, topography, and surface-water interactions, as well as the sensitivity of groun...

Primary Non-Adherence to Electronic Prescriptions in Lithuania, 2018–2024: Nationwide Prevalence, Factors, and Regional Variation

Background/Objectives: Primary non-adherence occurs when a prescribed medicine is never collected, preventing treatment from the beginning. Despite non-adherence being a widespread problem, most evidence comes from Western European and North American systems, and the Baltic regio...

On the intersections of projected Hamiltonian orbits in cotangent bundles

Abstract We study the generic behaviour of Hamiltonian trajectories on a regular level set in the cotangent bundle, after projection to the base. We prove that for a generic submersive level set, projected trajectories have discrete (self-)intersections. Additionally, fixing end-...

SOLiD‐MaP: A Photoproximity Labeling Platform for Small Molecule Binding Site Mapping on RNA

RNA-targeting small molecules are emerging as promising therapeutic modalities, but their development requires methods that define binding sites and evaluate RNA target selectivity. Existing approaches for detecting ligand-RNA interactions have provided powerful foundations, yet...

Synthesis and Application of 3,3-Difluoro Sialic Acid as a Sialyltransferase and Neuraminidase Inhibitor

Abstract Sialic acid (Neu5Ac) is a monosaccharide terminating glycoconjugates, serving as ligands for lectins in health and disease. Tools to target sialyltransferases (STs) and neuraminidases (NEUs) are important in the study of sialoglycans. 3FaxNeu5Ac is a common ST inhibitor,...

Empowerment in EU energy law: connecting legal and sustainability transition perspectives

The EU advances consumer empowerment as one of the pillars of energy legislation, aiming to transfer ownership of the energy transition to citizens. Rights and instruments have been introduced that offer citizens new ways of engaging with energy. However, EU energy legislation la...

Oleic Acid Binding and Exchange Dynamics on NaYF4 Nanocrystals

Abstract Lanthanide-doped NaYF4 nanocrystals (NCs) are widely used for their exceptional photoluminescence properties. Their performance and processability are critically dependent on surface-bound ligands such as oleic acid. While these ligands stabilize NCs during synthesis and...

Stoichiometry-Dependent Specificity in Biotin Enrichment: A Benchmarking Framework for Proximity-Labeling Proteomics

ABSTRACT Proximity labeling methods (including, BioID, TurboID, ultraID), along with surface proteomics and microdomain mapping, enable proteome-wide identification of spatially proximal proteins via MS-based analysis. These workflows require specific enrichment of biotinylated p...

Cases of collective learning? Combining Value Creation and Multilevel Boundary Crossing in cross organizational Professional Learning Communities

In gaining insight into the complex process of learning in Professional Learning Communities (PLCs) both the Value Creation (VC) Framework and Multilevel Boundary Crossing (MBC) were combined as method of analysis in a multiple case study. The members of two heterogenic education...

Sex-specific associations of the plasma-proteome with incident coronary artery disease

AIMS: The etiology of coronary artery Disease (CAD) appears different for men and women, yet insights into underlying sex-specific biological mechanisms are limited. We integrated genomic and proteomic analyses to investigate sex-specific associations of the plasma-proteome with...

High altitude precipitation dynamics using long-term observations in a Himalayan catchment

Abstract. In the Himalayas, the interaction between climate, orography and land cover results in a highly heterogeneous precipitation pattern. Mountain precipitation, being the main driver of the water cycle, ultimately provides water for millions of people downstream. Our curren...

The longitudinal interplay between acculturation and intergroup contact in adolescence

Abstract In current multicultural societies, mutual adjustment of majority and ethnic minority groups is a crucial issue shaped by groups' acculturation preferences and their encounters. These aspects are particularly relevant in adolescence when young people extend their social...

How many bromeliads are there? History and future perspectives of species scientific discovery in the pineapple family

Societal Impact Statement It remains unclear how many plant species are not yet recorded by science. We illustrated the process by which species of the pineapple family in tropical America have been newly described to science to date, and we estimated how many species may still a...

Longitudinal analysis of the B-cell receptor repertoire across 30 years of ageing

Abstract Background The gradual decline in the functionality of the immune system during aging is commonly referred to as immunosenescence. This study aims to investigate changes in the B-cell receptor immunoglobulin heavy chain (BCR IGH) gene repertoire during natural aging and...

A FAIR annotated set of 60k+ in situ zooplankton images from the Greater North Sea and Greenland

Abstract. The North Sea is a productive shelf sea with a wide variety of hydrographic and biological conditions. It is subject to high anthropogenic pressures, including climate change, terrestrial nutrient loading, and the development of offshore wind farms, and the associated e...

Sea Level Emulator Intercomparison Project (SLEIP) Phase 1: Assessing emulated multi-century global mean sea level projections

Abstract. Simplified sea level modelling approaches calibrated against reference data, also referred to as sea level emulators, can explore future sea level rise and associated uncertainties with low computational cost. Here, we introduce the Sea Level Emulator Intercomparison Pr...

Perceived Accuracy of ‘Undetectable Equals Untransmittable’ (U = U) Affects Openness to HIV Serodifferent Partnering in Australia: National, Cross-Sectional Survey Results

Abstract Background HIV pre-exposure prophylaxis (PrEP) and viral suppression to an undetectable level (“Undetectable=Untransmittable” or “U = U”) are highly effective at preventing sexual HIV transmission between serodifferent partners (partners with different HIV statuses). The...

Prospects of HIV elimination among men who have sex with men: A systematic review of modeling studies

Abstract Background Despite advances in HIV treatment and prevention, men who have sex with men (MSM) remain disproportionately affected by HIV worldwide. This systematic review summarizes the results of mathematical modeling studies that evaluated whether interventions might eli...

The Problem of Temporal Misalignment in Longitudinal Causal Research

A common goal of longitudinal research in psychology and related disciplines is the study of causal effects over time. An often overlooked assumption in this context is temporal alignment, referring to a match between the timescale at which a longitudinal process operates, the ti...