Utrecht University

Exploring calibration-free luminescence thermometry with Mn 4+ anti-Stokes/Stokes emission

Mn 4+ -activated phosphors offer a unique possibility of calibration-free primary luminescence thermometry using the ratio of anti-Stokes to Stokes (AS/S) vibronic emission lines of the 2 E → 4 A 2 transition. Previous work used the AS/S emission of Mn 4+ for thermometry but alwa...

First-principles electronic transport properties of Ti and Ti-6Al-4V for modeling ultrashort-pulse laser ablation

Predictive modeling of ultrashort-pulse laser ablation requires temperature-dependent material parameters derived from the electronic structure, namely the electronic thermal conductivity, electron-phonon coupling, and heat capacity. These parameters are well documented for eleme...

District-level analysis of temperature-related excess mortality in the Netherlands

Background: While most epidemiological studies have assessed temperature–mortality associations at broad geographical scales, recent research highlights that temperature-related mortality risks are spatially heterogeneous due to local differences in exposure, vulnerability, and a...

Changes in groundwater-surface water interactions following two centuries of irrigation practices and groundwater use in the Upper Ganges-Yamuna interfluve, North India

Abstract. The Indo-Gangetic Basin (IGB) is a global hotspot for groundwater overexploitation. Previous studies have shown that groundwater levels initially rose due to enhanced recharge following the construction of irrigation canals, but subsequently declined as agricultural, mu...

Governing Solar Geoengineering at Planetary Scale: Pipe Dream or Possibility?

Solar geoengineering is being suggested by some scientists as a partial solution to the climate crisis. However, these hypothetical technologies to reflect parts of incoming sunlight back out into space pose significant governance challenges, due to their ecological risks, planet...

Evidence accumulation models of Navon interference

The Navon task is a classic paradigm for studying selective attention, in which participants identify target letters presented at either a local or global level within compound figures. Traditionally, differences in reaction time (RT) between local and global trials—so-called pre...

Treatment restrictions after acute stroke across nine European countries and their association with 90-day mortality: a post hoc analysis of the PRECIOUS randomised controlled trial

Background In patients with acute stroke, early withholding or withdrawal of life-sustaining therapies is associated with an increased risk of death. We used practice variation across nine European countries to assess whether this relation may be causal. Methods We performed a po...

Interpreting Air Temperature Trends Across the Antarctic Peninsula Between 1979 and 2025

Abstract The near‐surface temperature of the Antarctic Peninsula is marked by strong spatio‐temporal variability. In situ observations are scarce and therefore have limited spatial coverage. Furthermore, ERA‐5 reanalysis does not have a sufficient spatial resolution to capture th...

Super Warm Early Eocene Simulations With HadGEM3‐GC31‐LL

Abstract The early Eocene Climatic Optimum (EECO; 53.3–49.1 million years ago) represents the period of greatest sustained warmth in the Cenozoic (last 66 million years), with proxy‐data indicating global‐mean temperatures 10–16°C above preindustrial and atmospheric concentration...

Multiyear dual-isotope fingerprinting at South Asian receptor sites constrains carbon monoxide sources and enhanced oxidation

Carbon monoxide (CO) is an indirect short-lived climate forcer with uncertainties both in sources and its role in atmospheric oxidation. Based on nine winter-long dual-isotope campaigns at two South Asian receptor sites intercepting the continental outflow, we quantified CO sourc...

Dried Urine Spots for Quantification of C0 (Free) Carnitine Excretion: A Validated Method for Follow-Up and Confirmatory Testing of Primary Carnitine Deficiency

Primary carnitine deficiency (PCD), caused by Organic Cation Transporter Novel 2 (OCTN2) deficiency, is detected by newborn screening (NBS) through low blood free carnitine (C0) concentrations. Confirmation of the diagnosis may be supported by demonstrating increased urinary C0 e...

Effect Size Calculation Procedures in Exercise Intervention Meta-Analyses: A Scoping Review

BACKGROUND: Meta-analyses require the calculation of effect sizes for all included studies. The most common experimental design in exercise intervention studies is the pre-post control design. A number of different approaches exist for calculating effect sizes for this design, an...

The Effect of Training Exercise on Cartilage Zonal Composition and Structure at Two Differently Loaded Sites in the Juvenile Equine Metacarpophalangeal Joint

BackgroundThe aim of this study was to investigate the depth related spatial distribution of biochemical and structural components in articular cartilage at different topographical sites experiencing different loading within the juvenile equine metacarpophalangeal joint in two gr...

A multiregional serosurvey of RNA virus-reactive antibodies in bats and rodents reveals the enzootic presence of flavi- and paramyxoviruses in African Pteropodidae

Bats and rodents have been identified as reservoir hosts of diverse RNA viruses that pose potential risks to humans. However, overall virus prevalence in wildlife and underlying factors determining the zoonotic potential of reservoir-borne viruses remain poorly characterized. Vir...

Ocean circulation changes rather than global warming drove temperature trends across the Miocene Climatic Optimum

Early-to-Middle Miocene [23 to 13.8 million years ago (Ma)] climates were ∼6° to 9°C warmer than today. Around 16.9 Ma, benthic foraminiferal oxygen isotope (δ 18 O) records suggest pronounced warming, known as the Miocene Climatic Optimum (MCO) onset. However, explaining this pu...

Plasma metabolomics reveals candidate biomarkers associated with individual treatment response in psoriatic arthritis

Psoriatic arthritis (PsA) is a clinically heterogeneous inflammatory disease for which optimal treatment selection remains unclear. Robust biomarkers that predict treatment response and identify patient-specific factors to inform treatment choice could advance precision medicine...

Strengthening pharmacovigilance systems through Africa-Europe collaboration: Insights from a regulatory roundtable discussion

Background Many African countries have established national pharmacovigilance (PV) centers under their medicines regulatory authorities, but multiple barriers still limit system performance. Comprehensive, well-enforced PV regulations are often lacking, and the reporting culture...

Polymer Coating Adhesion Drives Functional and Biological Outcomes in Meniscus Implants

Achieving stable integration of drug-releasing polymer coatings with load-bearing meniscus implants remains a challenge in biomaterials engineering. In this study, four surface modification strategies, femtosecond-pulsed laser treatment, oxygen plasma, polydopamine, and an ethyl-...

The NBGENS project protocol: Pilot study for genetic newborn screening in Galicia

Background Conventional newborn screening (NBS) relies on mainly biochemical assays and remains limited by its dependence on detectable biomarkers within a narrow postnatal window, leaving many treatable genetic disorders unidentified. Advances in next-generation sequencing have...

Brief internet intervention for grieving children and adolescents: co-design and trial protocol

ISRCTN.org identifier: ISRCTN21132251.