Utrecht University

Optimal Participant Allocation in Individually‐Randomized Stepped‐Wedge Clinical Trials With One or More Treatments: Extensions to Realistic Settings

ABSTRACT In stepped‐wedge clinical trials the patients are randomized into separate groups. Each group transitions from no treatment to treatment at a different time period. The designs are useful when limited resources or geographical constraints make it impossible to treat all...

ERP signatures of prediction error in the comprehension of ambiguous plural pronouns in German

Communication may include ambiguous pronouns that refer to different antecedents. Behavioural studies show reduced processing costs for ambiguous pronouns, indicating an ambiguity advantage and shallow processing. This raises the question: “How does ERP evidence for ambiguous pro...

The role of selective attention in value-modulated attentional capture

Abstract Stimuli that reliably predict reward can increase their capacity to capture attention. This value-modulated attentional capture (VMAC) is typically viewed as independent of task goals or physical salience, arising from associative learning. However, recent evidence sugge...

Do Androgens and Sex Hormone–Binding Globulin Mediate Sex Differences in the Risk of Stroke and Myocardial Infarction? The KORA Study

BACKGROUND: Sex differences in cardiovascular disease are well established, but the role of androgens and sex hormone-binding globulin (SHBG) remains unclear. We investigated whether these hormones and SHBG mediate sex differences in the risk of stroke and myocardial infarction (...

Towards network-based care: a three-phase study to explore the Networkintake as an entry point into network-oriented mental health services

Background A systemic transformation toward recovery-oriented, network-based care is essential to address persistent challenges in mental health services. To catalyze this transformation, the Networkintake approach has been developed to support a participatory approach to a compr...

Practice variation in hospital care for pelvic organ prolapse and urinary incontinence: an analysis of specialists’ expectations, cross-sectional claims data, and the role of clinical guidelines

Abstract Background Pelvic floor disorders, specifically pelvic organ prolapse and urinary incontinence, are highly prevalent conditions that exhibit substantial practice variation. This study aims to examine the relationship between clinical practice guidelines and practice vari...

Hochschild cohomology of Hilbert schemes of points on surfaces

Abstract We compute the Hochschild cohomology of Hilbert schemes of points on surfaces and observe that it is, in general, not determined solely by the Hochschild cohomology of the surface, but by its “Hochschild–Serre cohomology” – the bigraded vector space obtained by taking Ho...

How Gaussian can our Universe be?

Gravity is a non-linear theory, and hence, barring cancellations, the initial super-horizon perturbations produced by inflation must contain some minimum amount of mode coupling, or primordial non-Gaussianity. In single-field slow-roll models, where this lower bound is saturated,...

Lifting primordial non-Gaussianity above the noise

Primordial non-Gaussianity (PNG) in Large Scale Structures is obfuscated by the many additional sources of non-linearity. Within the Effective Field Theory approach to Standard Perturbation Theory, we show that matter non-linearities in the bispectrum can be modeled sufficiently...

Frontier technology adopters and the aggregate decline of routine jobs

We provide micro-founded evidence on how establishment-level adoption of frontier technologies shapes the economy-wide occupational employment structure. Linking survey data on technology adoption between 2011 and 2016 by 1660 German incumbent establishments to administrative wor...

Changes in dyadic emotional flexibility and expressivity during parent–child interactions following successful treatment of child anxiety

Abstract Child anxiety is linked to emotions during parent–child interactions, and observing emotional flexibility and expressivity may reveal treatment-related changes. This observational study investigated whether changes in dyadic emotional flexibility and expressivity were as...

Reliability, validity, and change over time in disinhibited and disruptive behaviors assessed with the age‐adapted disruptive behavior diagnostic observation schedule in children aged 5–12 years with ADHD

Abstract Background Previous research has shown that the disruptive behavior diagnostic observation schedule (DB‐DOS) is a valid and reliable clinic‐based assessment of disinhibited and disruptive behaviors in preschoolers. We adapted the DB‐DOS for use in children aged 5–12 year...

Graphene-based Photodetector with Engineered Hot-Carrier Cooling Dynamics

Abstract Graphene has emerged as a promising material for integration into silicon photonics, owing to its ultrafast and broadband photoresponse without the need for an external bias voltage. This photoresponse relies on the photo-thermoelectric effect created by hot carriers. A...

DUTCH weight control in atrial fibrillation study (DUTCH-WAIST)

Abstract Background Obesity is a well-established and highly prevalent risk factor for atrial fibrillation (AF) and its progression by promoting structural and electrical atrial remodelling, leading to AF recurrence and persistence. Weight loss is expected to reverse atrial remod...

Teachers’ perceptions and self-reported practices regarding teaching personal and social skills in primary physical education: A survey study

Personal and social development constitutes an important goal of physical education (PE) curricula worldwide. PE teachers aiming to implement the intended personal and social development goals may benefit from employing specific teaching strategies such as encouraging peer collab...

Occupational nanoparticle exposure and its effects on pulmonary health, cardiovascular health, and systemic biomarkers: a scoping review

Abstract Background Occupational exposure to nanoparticles occurs across diverse industrial sectors. Preclinical studies indicate that such exposures may pose health risks. However, characterization of these risks in real-world occupational-environments remains limited. Objective...

Co-Encapsulation and In Vitro Gastrointestinal Release of Gallic Acid and Curcumin: A Comparison between Double Emulsions and Templated Core-Laden Bubble Systems

Abstract This study examines how the intermediate phase in hierarchical colloidal carriers influences the co-encapsulation and in vitro gastrointestinal release of hydrophilic gallic acid and hydrophobic curcumin, using double emulsions (DE; W1/O/W2) and templated core-laden bubb...

A Deep BSDE Approach for the Simultaneous Pricing and Delta-Gamma Hedging of Large Portfolios Consisting of High-Dimensional Multi-asset Bermudan Options

Abstract. A deep BSDE approach is presented for the pricing and delta-gamma hedging of high-dimensional Bermudan options with applications in portfolio risk management. Large portfolios of a mixture of multi-asset European and Bermudan derivatives are cast into the framework of d...

PRO4RS - Developing, aligning, and implementing policies on research software for research performing organisations

Research software is essential to modern science, yet many research-performing organisations lack coherent policies to support its development, sustainability, and recognition. Despite its central role in research outcomes, research software and its personnel are often excluded f...

Enhancing Urban Air Quality Mapping through Novel Measurement and Modelling approaches, and Citizen Science: Actionable Insights from the RI-URBANS Project

Air Quality is among the most pressing environmental issues impacting upon urban populations. Traditional air quality networks can assess time trends and assess compliance to air quality regulations, but lack the spatial and temporal resolution to understand individual exposure t...