Utrecht University

Brief internet intervention for grieving children and adolescents: co-design and trial protocol

ISRCTN.org identifier: ISRCTN21132251.

The NBGENS project protocol: Pilot study for genetic newborn screening in Galicia

Background Conventional newborn screening (NBS) relies on mainly biochemical assays and remains limited by its dependence on detectable biomarkers within a narrow postnatal window, leaving many treatable genetic disorders unidentified. Advances in next-generation sequencing have...

Density-dependent aggregation underlies spatial self-organization in coastal dunes

Across coastal ecosystems, habitat-forming organisms interact with wind and water to generate biogeomorphic feedbacks that produce spatially patterned landscapes. Such spatial patterns can emerge through different self-organizing mechanisms, with contrasting implications for ecos...

Expanding the boundaries of linguistic reasoning in L1 education

Linguistic understanding is increasingly recognized as valuable in L1 education in its own right, not merely as a means to improve literacy. Research on linguistic reasoning, which combines general reasoning skills with subject-specific ways of thinking about language, has begun...

The one-Layer Antarctic model for Dynamical Downscaling of Ice–ocean Exchanges (LADDIE) version 2.0

Projections of Antarctic mass loss and its contribution to sea-level rise are highly sensitive to the applied ocean-driven melting. As fully coupled continental-scale ocean–ice sheet models are scarce, ice sheet models are typically run in standalone configurations, forced with p...

FOMO in Sub-Saharan African AI Hype: The Quest for a Decolonized AI Adoption Framework

Based on an abductive analysis of 54 opinion, editorial, and analytical articles published between 2019 and 2025 in nine English-speaking Sub-Saharan African countries, this study examines negotiation of the place of AI within journalism. Conceptualizing AI hype as a form of meta...

Self-Assembling Nanoparticles to Assess Multivalent Interactions between Influenza A Virus Hemagglutinin and Glycan Surfaces

Abstract The multivalent display of surface glycoprotein hemagglutinin (HA) on Influenza A viruses (IAVs) enhances the overall binding avidity to sialylated glycans on host cell surfaces. While precomplexing HA trimers with antibodies increases multivalency and avidity, this meth...

Validating Type 2 Diabetes Diagnoses Across the Madrid Hospital Network: Evidence for Secondary Use of the CMBD in the European Health Data Space

Background/Objectives: Hospital discharge data are increasingly reused for research and within health data spaces, but their value depends on accurate diagnostic coding. The validity of type 2 diabetes mellitus (T2DM) coding in the Spanish hospital discharge database (CMBD) had n...

Artificial Intelligence and democracy: A Delphi Study Into Opportunities and Threats

As Artificial Intelligence (AI) penetrates all sectors of society, academic attention to its relationship with democracy is rapidly increasing, leading to a growing body of literature. Optimists expect AI to strengthen democracy, while pessimists argue that it may undermine its e...

Editing by prompt. How professional editors use ChatGPT when revising business texts

Writing technologies shape writing processes and practices. This was true of word processing, speech recognition, and writing with internet-based sources, each of which changed how writers produced and revised text. Generative AI may have an even more fundamental impact because i...

Strategising social innovation paradoxes: four faces of energy citizenship

Social innovation (SI) is an increasingly prominent area of innovation. Involving changes in social relations, SI practice is pervaded with tensions and apparent paradoxes, however. The ‘productive use of paradox’ has been articulated theoretically and demonstrated empirically, b...

Reversible Inhibition of Ammonia Monooxygenase by 1,9-Decanediol Triggers a RegB-RegA-Associated Energy Crisis and Stress Response in Nitrosomonas europaea

Abstract 1,9-decanediol, a rice-derived biological nitrification inhibitor (BNI) suppresses soil nitrification and nitrous-oxide emissions, but the mechanisms of action against ammonia-oxidizing bacteria remain unclear. Combining physiology and transcriptomics in Nitrosomonas eur...

Delayed diagnosis of acute coronary syndrome in out-of-hours primary care: insights from a case-control study

Adequate triage of acute chest discomfort in out-of-hours services in primary care (OHS-PC) is crucial for minimising delays in the diagnosis of acute coronary syndromes (ACS) and subsequently limit myocardial damage. The objective was to identify predictors of delayed ACS diagno...

Mapping Functional Transitions across Protein Homologues from a Single Simulation: Application of gEDES-HM to Adenylate Kinases

Abstract Proteins fluctuate across different conformational states, which constitute a dynamic ensemble that regulates their interaction networks and functions. Predicting the conformational landscape remains a computational challenge, and even more difficult is capturing the lin...

Divergence Between Marker Expression and Phenotype During Human Corneal Endothelial Cell Expansion

Purpose: The purpose of this study was to compare whether conventional marker-based assessments adequately reflect phenotypic stability during serial passaging of two established culture protocols for primary human corneal endothelial cells (CEnCs). Methods: Primary CEnCs were is...

Aridity regulates scale-dependent effects of multiple resource additions on productivity stability in Eurasian grasslands

Increasing the supply of multiple limiting resources generally reduces biodiversity and community stability in grasslands. Aridity is known to modify biodiversity-stability relationships, yet it remains unclear whether the effects of multiple resource supply on biodiversity and s...

Consistent estimates of carbonyl sulfide and methane stratospheric lifetimes retrieved from AirCore profiles at different latitudes

Stratospheric loss is a major sink for both carbonyl sulfide (COS) and methane (CH 4 ), but their stratospheric lifetimes and sinks remain poorly constrained because high-resolution observations of their vertical distributions in the lower stratosphere are sparse. Here, we estima...

Effective Worker Resistance and Realist Ideology Critique

Abstract When do workers have good reasons to endorse a specific resistance strategy against managerial injustice? The answer partly requires clarifying whether that form of resistance is effective. But how should we understand efficacy? Political theorists cannot simply refer th...

Policy-as-practice: exploring the ‘hidden sides’ of policy-making in sustainability transitions

While research on the politics of transitions has examined power dynamics, coalitions, and value contestations, the ‘hidden’ sides of operational governance, such as micro-political dynamics, strategies and tensions within decision-making spaces, remained largely underexplored. C...

Edge Multiway Cut and Node Multiway Cut are Hard for Planar Subcubic Graphs

Abstract It is known that the weighted version of Edge Multiway Cut (also known as Multiterminal Cut ) is -complete on planar graphs of maximum degree 3. In contrast, for the unweighted version, -completeness is only known for planar graphs of maximum degree 11. In fact, the comp...