Utrecht University

An ecosyndemic framework for understanding obesity: Spatial clustering of health, environmental and socioeconomic disadvantage in the Netherlands

Abstract Introduction Obesity and related health conditions are unevenly distributed across neighborhoods, often co-occuring with multiple health challenges and socioeconomic disadvantages. Using an ecosyndemic framework, which integrates ecological and social dimensions that con...

Widespread thermophilization but weak link to climate warming in Europe’s summit plant communities

Abstract Recent changes in alpine vegetation are often attributed to climate warming, particularly community composition shifts towards more warmth-associated species, or thermophilization. Here we assess the link between thermophilization and warming across 53 European mountain...

Navigating regulatory scenarios for accelerating drug repurposing in rare diseases: a multi-stakeholder perspective on the challenges and opportunities

<title>Abstract</title> Background: The lack of treatments for patients with a rare disease calls for innovative approaches in drug development. A potential solution to accelerate therapy development is to find new therapeutic uses for existing drugs, i.e. drug repurposing. One w...

Catalogue of strong nonlinear surprises in ocean, sea-ice, and atmospheric variables in CMIP6

Abstract. The Coupled Model Intercomparison Project Phase 6 (CMIP6) archive was analysed for the occurrence of Strong Nonlinear Surprises (SNS) in future climate-change projections. To this end, we built an automated detection algorithm to identify SNS in a reproducible manner. T...

Failure to track a stable AMOC state under rapid climate change

Abstract The Atlantic Meridional Overturning Circulation (AMOC), a tipping element of the climate system, currently has an estimated global warming threshold for collapse of +4.0 °C (uncertainty range 1.4–8 °C). However, such a threshold may not be meaningful because AMOC stabili...

Modulating pressure in the Orbitrap improves sensitivity and mass resolution in charge detection mass spectrometry

Abstract Native mass spectrometry has become a key method for studying macromolecular assemblies, providing insights into structures, stoichiometries, and binding interactions. A key aspect for the transmission of electrospray-generated bioparticles into the mass analyzer is the...

Prospective analysis of pre-diagnostic untargeted plasma metabolomics and risk of triple-negative breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Triple-negative breast cancer (TNBC) accounts for 10–15% of newly diagnosed breast cancer, and its aetiology is poorly understood compared to other breast cancer subtypes. We applied untargeted metabolomics to identify novel biological pathways associated with TNBC risk and poten...

Molecular investigation of Campula oblonga (Cobbold, 1858) reveals complex evolutionary history of parasites within the family Brachycladiidae (Odhner, 1905), parasites of wild cetaceans.

Speciation in parasites of marine mammals represents an important yet relatively understudied facet of marine research.Evolutionary and ecological interactions between the trematode family Brachycladiidae and their cetacean definitive hosts have previously been investigated at fa...

Sector-specific clean water scarcity and competition under global change

Abstract While the impact of future climate change on physical water availability has been extensively studied, the interplay with water quality and the associated impact on water scarcity—particularly the ensuing competition among sectors (domestic, irrigation, livestock, manufa...

Feasible geological carbon dioxide storage projections require updated cost and geological potential assumptions

Integrated Assessment Models project large-scale deployment of carbon dioxide geological storage across many climate change mitigation pathways. However, the feasibility of these projections - particularly concerning near-term scale-up rates - has been criticised. Here, we examin...

Radiological Late Dental Adverse Effects Following Treatment for Paediatric Head and Neck Rhabdomyosarcoma: Results of a Transatlantic Multicentre Cohort Study

ABSTRACT Objectives Rhabdomyosarcoma represents the most common paediatric soft tissue sarcoma, with 40% occurring in the head and neck region. Given that survival rates now reach 80%, minimising late adverse effects, particularly dental developmental complications, has become a...

Urban sustainability and the governance of heterogeneous energy systems

Abstract This special feature brings into dialogue debates that have evolved mainly separately: scholarship on infrastructural heterogeneity in Southern cities and research on distributed and decentralized energy transitions in the North. Drawing on empirical cases from Africa, t...

The money laundering market: An economic analysis

Criminals launder their proceeds from crime, either themselves or by paying a professional, to disguise the link between the criminal, the crime, and the proceeds. This allows the criminal to spend the proceeds more freely and lowers the chance of receiving unwanted attention fro...

Patients’ and clinicians’ perspectives on telemedicine to monitor patients on systemic treatment for psoriasis or atopic dermatitis - a mixed methods study

Background For patients with stable psoriasis or atopic dermatitis (AD) receiving systemic treatment, telemedicine may offer a viable alternative to in-person consultations. However, perspectives of these patients and dermatological care providers (DCPs) regarding telemedicine ar...

Pathways for mainstreaming nature-based solutions for climate adaptation: grounding, capitalising, embedding and anticipating across 12 Mediterranean cities

Abstract The implementation of urban nature-based solutions (NbS) is gaining momentum, with significant efforts to advance the use of green walls, constructed wetlands, raingardens and other solutions in Europe. We examine nine case studies across the Mediterranean to analyse dif...

Revisiting the quantum geometry of torus-fibered Calabi-Yau threefolds

About ten years ago, Katz, Klemm and Huang conjectured that topological string amplitudes on compact, elliptically fibered Calabi-Yau threefolds at fixed base degree could be expressed in terms of meromorphic Jacobi forms for SL(2,\mathbb{Z}) <mml:math xmlns:mml="http://www.w3.or...

Logarithmic prismatic cohomology, motivic sheaves, and comparison theorems

Abstract We prove that (logarithmic) prismatic and (logarithmic) syntomic cohomology are representable in the category of logarithmic motives. As an application, we obtain Gysin maps for prismatic and syntomic cohomology, and we explicitly identify their cofibers. We also prove a...

The Dutch cardiomyopathy registry (DCR); rationale and registry design

BACKGROUND: Cardiomyopathies are important causes of arrhythmias, sudden cardiac death, and heart failure. With accumulating knowledge in clinical, genetic, and molecular phenotyping, the number of distinct disease entities is growing. There is a need for broad, inclusive, high-q...

The climate policy modelling protocol - Climate policy representation in integrated assessment models

Model-based scenario analysis is often used to evaluate the impact of national climate policies on global greenhouse gas (GHG) emissions. ‘Current Policies’ scenarios are thus normative scenarios that attempt a realistic representation of projected emissions that include policies...

Growing, Stabilising, Downsizing: The Evolution of Social Enterprise Scaling Ambitions

Entrepreneurship research recognises growth ambitions as an antecedent of realised growth. Such ambitions are however dynamic, adapting to changing conditions. In social enterprises, the corresponding construct is scaling ambitions, which span both social impact and financial obj...