Utrecht University

Multicentre performance and consistency of two deep learning models for malignancy probability estimation of incidental pulmonary nodules

Abstract Objectives A screening-trained deep learning (DL) model (DL1) for pulmonary nodule malignancy probability estimation on CT previously demonstrated good discrimination on a single-centre dataset of incidental nodules. An updated DL model (DL2) was trained on both screenin...

Evidence for non-mucinous pulmonary lesions with adenocarcinoma in situ morphology exceeding the current 3 cm WHO threshold

CONTEXT: The World Health Organization (WHO) recognizes adenocarcinoma in situ (AIS) of the lung for tumors up to 3 cm in size. Larger tumors with a lepidic growth pattern are classified as invasive lepidic predominant adenocarcinoma. OBJECTIVE: The aim of this study was to demon...

Optimal Size of Electrocorticography Grids for Classification of Hand Movements

Abstract Implanted Brain-Computer Interfaces (BCIs) hold significant promise as a replacement for conventional assistive technologies for people with extensive motor impairments. In recent years, significant progress has been made in enhancing BCI performance, bringing clinically...

Pyramidal cell types and circuit organization of the mouse insular cortex reveal functional specializations

Abstract The insular cortex integrates interoceptive and exteroceptive information to mediate bodily homeostasis, emotion and learning. However, the cellular and circuit substrates governing insular functions are poorly understood compared to primary cortices. Here we quantify de...

The Search for Life Elsewhere: Avoiding Hype and Fostering Public Understanding

The search for life beyond Earth presents unique challenges for science communication due to its interdisciplinary nature, the potential for groundbreaking discoveries, and the inherent uncertainties involved. The Lorentz Center workshop Breaking News: We Found Extraterrestrial L...

The recent enhancement of the surface melt over the Antarctic Peninsula dictated by thermodynamics

Intense surface melt and subsequent meltwater ponding are the key triggers for the disintegration of ice shelves in the Antarctic Peninsula (AP). Although a long-term decline in AP surface melt has been evident since the early 1990s, episodes of intense surface melt events have f...

Lithological schematization of the Karnali fluvial fan (Nepal’s Terai Arc Landscape) using electrical resistivity tomography as a basis for hydrogeological investigations

Abstract In the Nepalese and Indian Terai Arc Landscape (TAL), protected nature areas are supported by groundwater systems that have remained largely understudied. This study schematizes the lithology of the Karnali fluvial fan located in the Bardia district (Nepal) as a basis fo...

Transcranial alternating current stimulation as treatment for delirium: A multicenter randomized double-blind sham-controlled pilot study on safety and feasibility

Delirium is an acute neuropsychiatric syndrome with currently no effective treatment. The acute encephalopathy underlying delirium is characterized by diffuse oscillatory slowing on electroencephalography (EEG). Based on its capacity to modulate oscillatory activity, 10 Hz transc...

AI, citizen science data and expert opinions: towards an improved fossil identification process

Accurate identification of fossils is instrumental to palaeontological research but requires expert knowledge, is time consuming and subject to human biases. Through citizen science platforms and apps, artificial intelligence (AI)-assisted identifications can mitigate those chall...

Preservice mathematics teacher experiences and insights into integrated STEM assessment design challenges

Designing effective assessments in STEM-integrated mathematics education is a vital yet insufficiently developed skill among pre-service teachers (PSTs). This study uses a sequential explanatory mixed-methods approach to explore specific challenges faced by 56 PSTs enrolled in a...