Uppsala University

Plasma proteomic profiling of septic shock and acute pancreatitis identifies shared signatures and disease-specific pathways

Abstract Septic shock represents the most severe form of infection-driven systemic inflammation, whereas acute pancreatitis induces a sterile inflammatory response. Although clinically similar, their molecular profiles may reveal distinct mechanisms underlying infectious and non-...

Dopamine D2/3 receptors and functional connectivity during fear extinction: A PET-fMRI study

Background The ability to learn what is dangerous in the environment and what no longer exerts a threat is essential for survival. The latter process is studied using Pavlovian fear extinction, the repeated presentation of a feared stimulus that gradually attenuates the fear resp...

Albumin-Binding Moieties Tune the Pharmacokinetics and Tumor Uptake of 177Lu-Labeled GRPR Radioligands

Abstract Although the gastrin-releasing peptide receptor (GRPR) is an established theranostic target across multiple cancers, many GRPR-targeting peptides undergo rapid renal clearance, limiting tumor uptake and therapeutic exposure. Albumin-binding moieties (ABMs) reversibly int...

Experimental radiotherapy with the gastrin-releasing peptide receptor (GRPR) antagonist [177Lu]Lu-AU-SAR-M1 in a prostate cancer murine model using reduced-frequency dosing

The gastrin-releasing peptide receptor (GRPR) is highly expressed in prostate and breast cancers and hence serves as a legitimate target for radionuclide therapy (TRT). Radiolabeled GRPR antagonists are attractive radionuclide-carriers for TRT, due to their rapid tissue penetrati...

Mechanistic insights into Nrf2- and PARP1-mediated radioresistance of glioblastoma stem cells under photon, proton, and carbon ion irradiation: An in vitro study

Glioblastoma multiforme (GBM) exhibits strong resistance to radiotherapy, partly driven by glioblastoma stem-like cells (GSCs) with enhanced redox homeostasis and DNA repair capacity. This study evaluated whether targeting Nrf2-mediated antioxidant signaling and PARP1-dependent D...

The locus of psychic distance

Purpose This paper argues that longstanding inconsistencies in psychic distance research arise from a fundamental locus problem: the construct has drifted away from its original definition as barriers to information flow between the firm and the market. The purpose is to re-estab...

Modelling of wind flows over realistic forests with LES

Abstract. A large-eddy simulation (LES)-based model for the representation of wind flows over realistic forests and topography is presented. Terrain elevation and forest density maps from airborne laser scans are employed to investigate the importance of specific model choices re...

Cardiovascular and thromboembolic risk in anti-neutrophil cytoplasmic antibody-associated vasculitis: a nationwide matched cohort study by disease, sex, and familial risk

OBJECTIVES: To investigate influence of sex, diagnosis (granulomatosis with polyangiitis (GPA) vs. microscopic polyangiitis (MPA)), and familial factors on cardiovascular disease and thromboembolism (CVD-TE) risk in patients with anti-neutrophil cytoplasmic antibody-associated va...

The fitness landscape of a form II rubisco in a photosynthetic bacterium guides engineering of oxygen tolerance

Abstract Rubisco is an important but challenging protein engineering target. Fast and selective rubiscos could enhance photosynthesis in plants and accelerate biobased production processes. To facilitate engineering of rubisco, we applied an in vivo screen that couples rubisco ac...

Engendering human and nonhuman health: a critical socio-ecological approach to zoonotic disease

Abstract Addressing zoonotic diseases often calls for collaborative efforts across health and agriculture sectors to find ways to control or eliminate these pathogens. However, existing techno-scientific and biomedical interventions frequently fall short given the siloed nature o...

Interplay between the role of DNA methylation in regulating gene expression and TE-silencing in a reptilian methylome

Abstract DNA methylation is a major component of eukaryotic genomes with an important role in the defence against transposable elements, to transcriptionally silence their activity and prevent transposition. DNA methylation also plays a major role in the regulation of gene expres...

Genomic consequences of admixture in an experimentally founded sand lizard population

Abstract Conservation interventions are increasingly required for species threatened by population declines and isolation due to anthropogenic pressures. Small, isolated populations are particularly vulnerable to the loss of genetic diversity, increased inbreeding, and the accumu...

Ultra‐Tough Hybrid Supramolecular Gelatin Hydrogels

ABSTRACT Natural load‐bearing tissues derive mechanical performance from sequential self‐assembly, in which collagen fibrils first compact and are then stabilized by enzymatic covalent crosslinking. Replicating this design in synthetic hydrogels while limiting swelling and preser...

Characteristics of Monozygotic Twins Discordant for Anorexia Nervosa: Comprehensive Risk Evaluation for Anorexia Nervosa in Twins (CREAT) Study

ABSTRACT Objective To characterise the clinical and phenotypic profile of the Comprehensive Risk Evaluation for Anorexia nervosa in Twins (CREAT) cohort, identify candidate risk and illness‐related correlates of AN, and establish a foundation for forthcoming biological, neuroimag...

Data distribution impacts the performance and generalisability of contrastive learning-based foundation models of electrocardiograms

Contrastive learning is a widely adopted self-supervised pretraining strategy, yet its dependence on cohort composition remains underexplored. We present Contrasting by Augmented Patient Electrocardiograms (CAPE) foundation model and pretrain on four cohorts (n = 5,203,269), from...

The plasma protein profile of left ventricular diastolic function

We aimed to characterize associations between plasma proteins and indices of left ventricular (LV) diastolic function in two population-based studies. Eighty-six cardiovascular-related plasma proteins measured by proximity extension assay (PEA) and echocardiography were assessed...

Exploring baryon semileptonic decays through polarization and entanglement

Abstract The unitarity of the Cabibbo–Kobayashi–Maskawa (CKM) matrix is a cornerstone of the standard model (SM). Precise tests of this unitarity require independent determinations of its elements, such as | V us |, which governs the transition between strange and up quarks. Curr...

Application Usability, Engagement, and Postpartum Weight Retention: Secondary Analysis of the INTER-ACT Randomized Controlled Trial.

Objective: To examine whether perceived usability of the INTER-ACT application influences postpartum weight loss and whether this effect is mediated by application use, motivational power, and implementation of lifestyle recommendations. Patients and Methods: Dutch-speaking women...

Analysis of Eigenvalue Clustering Leads to Optimal Scaling in Numerical Radiative Transfer

ABSTRACT We consider a multidimensional polychromatic radiative transfer (RT) problem, accounting for scattering processes in a general form, that is, anisotropic (dipole) scattering with partial frequency redistribution. Given a discrete ordinates () discretization, we report th...

Inhibitory neurotransmission in frontostriatal circuitry: implications for psychomotor and vegetative symptoms in depressive episodes

Abstract Background Gamma-aminobutyric acid (GABA) dysfunction has been implicated in depression, although research findings remain inconsistent. This may indicate that distinct biological mechanisms underlie different symptom profiles in depressive episodes. GABA deficiency migh...