Uppsala University

“Acknowledge my grief” - experiences and needs of bereavement support in Sweden following the death of a loved one

<title>Abstract</title> Background Grief affects most people at some point, and is commonly associated with psychological distress, reduced well-being, and difficulties in everyday functioning. Support for the bereaved is crucial for grief management, but there is a lack of evide...

Induction of type I and III interferons by viral and endogenous stimuli in systemic sclerosis

ABSTRACT Objective The interferon (IFN) system is activated in systemic sclerosis (SSc), but the driving mechanisms remain unclear. We asked whether type I and III IFN responses to Toll-like receptor (TLR)-7/8/9 stimulation of leukocytes from patients with SSc differ from healthy...

Dual-Channel Energy Transfer from Ligand-Centered Singlet and Triplet States to Trivalent Lanthanide Ions

Abstract Efficient light harvesting and subsequent energy transfer (EnT) to trivalent lanthanide ions (LnIII) are critical for achieving high-performance luminescent LnIII complexes. However, because of the complexity of the underlying dynamic processes, in-depth investigations o...

Multi-omics profiling reveals gene signatures and therapeutic targets in HER2-guided gastric cardia adenocarcinoma patients

Abstract Therapeutic targets for gastric cardia adenocarcinoma (GCA), particularly for HER2-negative patients, are lacking. Here, we conducted multi-omics profiling on 128 GCA patients using mass spectrometry, whole-exome sequencing, RNA-Seq, scRNA-Seq and spatial transcriptomics...

Dating low-temperature hydrothermal fluid activity with in situ Rb/Sr geochronology of partially chloritized biotite

Chloritization of biotite by fluids is common in low-temperature tectonic regimes. Using three metapelites from the Tatric Superunit in the Western Carpathians (northern Slovakia), we demonstrated that in situ Rb/Sr geochronology of partially chloritized biotite can be used to da...

Trajectories of refraction and strabismus from 2.5 to 12 years in a national cohort of extremely preterm children‐ the Extremely Preterm Infants in Sweden Study (EXPRESS)

Abstract Purpose To investigate the longitudinal development of refraction and strabismus in a national cohort of children born extremely preterm (EPT) and find relations to perinatal events and neurodevelopmental outcomes. Methods All surviving children born &lt;27‐gestation wee...

Forecast-based attribution of the role of stratospheric variability in weather extremes

Abstract. Variability of the stratospheric polar vortex, particularly its dramatic breakdown during sudden stratospheric warming (SSW) events, has been linked to a number of surface weather extremes. However, attributing the role of stratospheric variability in a specific observe...

The support program Parenting Young Children for parents with intellectual and developmental disabilities: parents’ experiences of the program’s impact on their parenting

Parenting Young Children is a home-based parenting support program for parents with intellectual and developmental disabilities. The program focuses on parents’ ability to care for and interact with their children and is adjusted to each parent’s needs through individualised goal...

Homicide at home: setting the agenda for an international collaboration to improve support for children bereaved due to family violence

Background: Bereavement due to fatal family violence (e.g. intimate partner homicide, filicide, parricide, siblicide) is a profoundly disruptive experience for children, with lifelong psychosocial consequences. Although the need for fatal family violence prevention is increasingl...

Deciphering the evolutionary origin of the enantioselectivity of short-chain dehydrogenases from plants toward 1-borneol

Abstract Enzyme engineering has produced numerous methods to optimize enzymes for biotechnological processes; however, less is known about how natural evolution creates new functionalities. We investigate the evolutionary emergence of enantioselectivity in plant borneol dehydroge...

Retired doctors as users of patient-facing electronic health records: a mixed-methods survey in the UK and Spain

<title>Abstract</title> Background Online patient access to electronic records is expanding internationally but remains contested. Although clinicians’ concerns are well documented, less is known about how doctors’ views change when they themselves become patients. Retired doctor...

Denoise Stepwise Signals by Diffusion Model‐Based Approach

ABSTRACT Stepwise signals are ubiquitous in single‐molecule detections, where abrupt changes in signal levels typically correspond to molecular conformational changes. However, these features are inevitably obscured by noise, leading to uncertainty in estimating both signal level...

Solvent‐Induced Structural Modulation in Nanoscale Covalent Organic Frameworks Enables High‐Performance NO 2 Sensing

ABSTRACT Covalent organic frameworks (COFs) offer exceptional structural and functional tunability, enabling performance optimization in separation, catalysis, and sensing applications. Here, we report a solvent‐induced strategy for inducing structural disorder in porphyrin‐based...

How Do Child Protection Workers Report and Assess Signs of Honour‐Based Violence? An Analysis of 138 Cases

ABSTRACT Honour‐based violence (HBV) is a serious social problem with significant health and social consequences for affected children. Despite growing policy attention, little is known about how child protection services address HBV in practice. This study examines how child pro...

Rural geography II: Bridging housing and homes in rural research

This report undertakes to bridge the notions of rural housing provision and homemaking, highlighting how structural conditions and lived experiences are mutually constitutive. Drawing on rural geography research, it explores how social relations, everyday practices, and engagemen...

Healing intervention for improving the efficiency and stability of tandem devices on industrial textured silicon

Monolithic perovskite/silicon tandem solar cells are widely regarded as the next-generation, low-cost, high-efficiency photovoltaic technology. However, achieving high-quality wide-bandgap perovskite top cells on industrial textured silicon, particularly using hybrid two-step dep...

What’s unfair about resultant moral luck?

Abstract A popular reason for denying resultant moral luck has to do with its alleged unfairness. In this paper, I argue that although two existing objections against the unfairness argument are unsuccessful, it ultimately fails. First, I criticize the objection that the unfairne...

One in seven has severe pain: a point-prevalence study of hospitalised patients across Africa

ABSTRACT: Acute pain in hospitalised patients is common, yet African data are scarce. We conducted a prospective point-prevalence study of hospitalised adult patients across Africa to determine acute pain prevalence and severity and investigate associations of pain with critical...

Layered Defect-Filling co-Assembled Carbazole-Based SAMs Deliver 20% Organic Solar Cells and 17% Mini-Modules

Abstract Self-assembled monolayers (SAMs) are widely used as hole-transport layers (HTLs) in organic solar cells (OSCs), yet conventional single-component SAMs often form quasi-monolayers with incomplete coverage and interfacial defects that become increasingly detrimental upon d...

Investigating a Devonian vertebrate assemblage with synchrotron microtomography of coprolites

Abstract Fossilised faeces (coprolites) are a unique source of information as they record palaeontological evidence of animal behaviour (autecology) as well as interactions between extinct organisms and their environment (synecology). Four samples bearing coprolites found in a ne...