Uppsala University

High Risk of Metabolic Side Effects Among New Paediatric Antipsychotic Users in Sweden—A Register‐Based Study

PURPOSE: This study aims to assess the risk of metabolic side effects among paediatric new users of antipsychotics in Sweden, focusing on differences between substances and sexes. METHODS: Children aged 5-17 years, who were new users of antipsychotics between 2014 and 2021, were...

A coherent family support model (Co-Fam) for preventing and treating childhood overweight and obesity: protocol for a randomized hybrid type 2 effectiveness-implementation trial

Abstract Background Swedish child healthcare involves school health services, primary healthcare, and pediatric clinics. Family-based programs addressing child diet, eating behavior, parental feeding practices and physical activity show promise for preventing and treating overwei...

Combined effects of long‑term air pollution exposures on adult active asthma: a quantile g-computation analysis

Abstract Background Air pollution is a well‑established risk factor for the development of asthma, yet most studies examine pollutants individually, failing to capture the health effects of real‑world pollutant mixtures. Assessing long-term multipollutant exposure is essential fo...

Diet Quality and Weight Gain Among Women in the Aboriginal Family Birthing Program in South Australia

Background: This study assessed diet quality and the association between engagement with nutrition support bundles and weight gain among pregnant women having Aboriginal and Torres Strait Islander babies who participated in the Aboriginal Family and Baby Bundles implementation pr...

Gaps in unconventional superconductors

The energy gap is one of the defining properties of a superconductor and appears because the quasiparticle excitations radically change once a metallic system enters the superconducting state. Unconventional superconductors typically exhibit a non-uniform gapping and therefore sh...

NAST 2.0: Magnetic Field Effects and Marcus–Levich–Jortner Theory for Complex Open-Shell Systems

Abstract We present a new version of the nast software package for predicting the kinetics of unimolecular spin-dependent processes, including intersystem crossings, spin-forbidden reactions, and spin crossovers with nonadiabatic statistical theory. With substantial extensions an...

A DPP6 ‐Targeted PET Tracer for Non‐Invasive Imaging of Transplanted Human Islets

ABSTRACT Introduction Dipeptidyl peptidase‐like protein 6 (DPP6) is a potential molecular imaging biomarker for pancreatic and transplanted islets of Langerhans. 4hD29 is a single‐domain antibody with nanomolar affinity for DPP6. Here, we demonstrate the generation and validation...

Magnetothermal Wax Capsule for Localized Gastrointestinal Drug Delivery

Abstract Oral drug delivery to gastrointestinal (GI) lesions remains challenging, as current systems rely on physiological triggers such as pH, enzymes, and luminal pressure, which vary widely among patients. To address this, an ingestible capsule was developed to enable on-deman...

Arrested development: analyzing popular resistance against the arrest of war-criminals in DR Congo and Liberia

International war crimes trials have become a common feature of post–civil war politics, sparking debate about the effectiveness of such interventions. A key shortcoming in the literature is its neglect of the critical moment when wartime leaders are arrested and that such incarc...

Adaptive response to serine and glycine deprivation enhances the stemness potential of pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDAC) develops within a nutrient-poor microenvironment, where pancreatic cancer stem cells (PaCSCs) can persist despite limited oxygen and nutrient availability. This resilience partially relies on mitochondrial metabolic flexibility. Serine and...

A first-in-human, phase I/IIa trial of the T cell immunotherapy personalised tumour trained lymphocytes in patients with advanced colorectal cancer: Study protocol

Background Adoptive T cell therapy is a promising alternative to conventional therapies for certain solid tumours. Personalized tumour-trained lymphocytes (pTTL) is an autologous T cell therapy derived from tumour-draining regional lymph nodes (RLNs), trained to target patient-sp...

Ultrafast laser-driven topological phase patterning

Microscopic and dynamic control over quantum states is essential for bridging fundamental studies of material properties to device function. Realizing such control at combined high spatial resolution and ultrafast temporal precision remains a major challenge. Here, we demonstrate...

Draft genome sequence of Bacillus paranthracis S23, isolated from saline soil of Lake Bogoria, Kenya

S23 was isolated from saline soil of Lake Bogoria. Its draft genome, generated using Illumina HiSeq sequencing, comprises 5,583,771 bp across 205 contigs and contains 5,741 predicted protein-coding genes. Genome mining identified biosynthetic gene clusters associated with the pro...

Generational changes in lung function in adults from several world regions: results from the Burden of Obstructive Lung Disease study

This study estimated birth cohort effects on lung function using BOLD (Burden of Obstructive Lung Disease) data from 28 569 adults born between 1902 and 1976 across 41 sites in 34 countries. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1 ) and the FEV 1 /FVC...

Process-oriented evaluation of machine learning and physics-based models for wave parameter prediction under extreme conditions in a fetch-limited sea

Machine learning approaches are increasingly used for wave prediction, yet their ability to represent the physical processes governing extreme waves in fetch-limited seas remains insufficiently understood. This study evaluates four machine learning models for reconstructing signi...

Antihypertensive Treatment and Risk of Metabolic Associated Fatty Liver Disease: A Drug-Target Mendelian Randomization

BACKGROUND: Metabolic dysfunction-associated fatty liver disease, conventionally known as nonalcoholic fatty liver disease (NAFLD), affects over a quarter of the global population and lacks approved pharmacological treatments. We investigated whether elevated blood pressure (BP)...

Residential relocations, well-being and mover characteristics in Sweden: divergences between distances and ethnicity

Residential relocation is a life course event that most people undergo several times in their life course. Nevertheless, how overall well-being changes as a consequence thereof is rarely assessed. Moreover, relocation is often taken as a one-size-fits-all life event. This study e...

A review of selected Swedish contributions to instrumentation at neutron scattering facilities

Abstract The European Spallation Source in Lund, Sweden, is the next generation neutron research facility that will provide unprecedented capabilities for particle physics as well as materials and life science research through its high brightness, long-pulse neutron source and ad...

MOUFLON: multi-group modularity-based fairness-aware community detection

Abstract In this paper, we propose MOUFLON, a fairness-aware, modularity-based community detection method that allows adjusting the importance of partition quality over fairness outcomes. MOUFLON uses a novel proportional balance fairness metric, providing consistent and comparab...

Failure to invest below-ground may limit the northern expansion of invasive knotweed: lessons from a two-phase transplant experiment

Abstract The ecological and evolutionary processes determining species distributions and range limits remain poorly understood. Ultimately, range limits depend on the species’ abilities to persist under heterogeneous conditions, by adaptive differentiation and phenotypic plastici...