UNSW Sydney

Efficacy and safety of canagliflozin are consistent across polypharmacy burden in CKD: the CREDENCE trial

Abstract Background Polypharmacy in chronic kidney disease (CKD) is substantial. Clinicians and patients are often reluctant to add medications to already complex regimens, partly due to concerns about diminishing efficacy and increased adverse effects. We assessed whether effica...

Human-inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity

Abstract We previously reported inherited RORγT deficiency in seven patients from three ancestries (Chilean, Palestinian, Saudi Arabian) with mycobacterial disease and chronic mucocutaneous candidiasis (CMC). We report here five additional patients from different ancestries (Afgh...

SBCR-A*: Supercover-Based Corridor Reconstruction for Optimal Path Length in Grid-Based Navigation

Abstract Grid-based path planning and optimization remain widely used in robotics and autonomous navigation because real environments can be discretized into binary occupancy grids, allowing algorithms such as A* to guarantee a solution whenever a collision-free path exists. Howe...

Weighted sliced inverse regression for scalable supervised dimensionality reduction of spatial transcriptomics data

Abstract With the dramatic take-up of spatially resolved transcriptomics biotechnologies, performing spatially-aware analysis of the resulting data is crucial to maximise advances in biological understanding. Dimensionality reduction is a first step in almost any analysis of spat...

Towards the Definition and Measurement of Routines and the Cognitive Processes that Underpin their Maintenance

Abstract The benefits of routines for daily functioning are widely acknowledged, yet, despite their apparent importance, methods for quantifying routine maintenance and the causes of their disruption remain lacking. Here, we propose a novel means of defining and quantifying routi...

Adaptive quadcopter model predictive control using remote monocular vision

This paper presents an adaptive control framework for quadcopter trajectory tracking in which all external state feedback is derived from a monocular video stream. Inspired by first-person view (FPV) piloting, the proposed system uses monocular video streamed to a remote ground s...

Adequate tetanus toxoid immunization and its correlates among married women with a recent live birth in Afghanistan: Insights from a national survey

This study aimed to determine the prevalence and correlates of adequate tetanus toxoid (TT) immunization among married women in Afghanistan. This cross-sectional study analyzed data from the 2022-2023 Afghanistan Multiple Indicator Cluster Survey (MICS), focusing on 12,450 marrie...

Perceived Accuracy of ‘Undetectable Equals Untransmittable’ (U = U) Affects Openness to HIV Serodifferent Partnering in Australia: National, Cross-Sectional Survey Results

Abstract Background HIV pre-exposure prophylaxis (PrEP) and viral suppression to an undetectable level (“Undetectable=Untransmittable” or “U = U”) are highly effective at preventing sexual HIV transmission between serodifferent partners (partners with different HIV statuses). The...

Faulted Rock Slope Stability Under Blasting Excavation Using Copula‐Based Rotated Anisotropic Random Fields

ABSTRACT Blasting excavation can induce permanent displacement in faulted rock slopes and adversely affect slope stability. Most existing stability assessments use deterministic approaches and therefore do not adequately account for the spatial variability and cross‐correlation o...

The physicochemical design, structure and permeability of the JCVI-syn3A minimal cell membrane

Abstract Minimal cells offer a platform to uncover the fundamental physicochemical principles of cellular life. While genomes, proteomes and metabolic networks of cells have been elucidated, the lipidome, which determines the physicochemical identity of the membrane, remains larg...

A Double‐Blind Randomised Controlled Crossover Trial of the Effect of Blue‐Enriched Ambient Light on Sleep in Older Adults With Sleep Disturbance: The CleverLights Study

ABSTRACT Light interventions have been investigated for treating sleep disturbances in older adults; however, findings are mixed. This proof‐of‐concept trial investigated the effect of blue‐enriched ambient light on electroencephalographic (EEG) sleep in older adults with self‐re...

Psychosocial interventions in childhood dementia: a call for action

Abstract Childhood dementia (CD) is a complex, rare, often under-recognised, and incurable neurogenetic group of disorders with neuromotor-behavioural symptoms and poor survival outcomes. Despite profound impacts, CD remains neglected and underfunded compared to other paediatric...

Estuarine benthic diversity declines with temperature across a tropical–temperate gradient

Estuarine benthic sediments are important habitats that support ecosystem health and productivity, but the drivers of large‐scale patterns in benthic diversity are not well documented. Using 18S amplicon sequencing of 425 sediment DNA samples from estuaries spanning 20° of latitu...

Through the Looking-Glass: A Scoping Review of Psychological Mechanisms of Psychedelic-Assisted Therapy for Substance Use Disorders

Abstract Purpose of Review Psychedelic-assisted therapy (PAT) has re-emerged as a potential intervention for substance use disorders (SUDs), yet the psychological mechanisms underlying behaviour change remain poorly synthesised. This scoping review mapped and evaluated proposed p...

The global diffusion limit for the space-dependent variable-order time-fractional diffusion equation

Abstract The diffusion equation and its time-fractional counterpart can be obtained via the diffusion limit of continuous time random walks with exponential and heavy-tailed waiting time distributions. The space-dependent variable-order time-fractional diffusion equation is a gen...

Oxygen-dependent subcellular redistribution of PHD3 links the hypoxic microenvironment to mitochondrial metabolic reprogramming in ccRCC

Abstract Clear cell renal cell carcinoma (ccRCC) is characterized by profound metabolic dysregulation, with both prolyl hydroxylase domain protein 3 (PHD3) and pyruvate carboxylase (PC) independently implicated in disease progression. Although each influences patient outcomes, a...

Multiscale characterization of cortical signatures in positive and negative schizotypy:a worldwide ENIGMA study

Positive and negative schizotypy reflect distinct patterns of subclinical traits in the general population associated with neurodevelopmental and schizophrenia-spectrum pathologies. Yet, a comprehensive characterization of the unique and shared neuroanatomical signatures of these...

A genomic catalog of Earth’s bacterial and archaeal symbionts

1 SUMMARY Microbial symbiosis drives the functional and phylogenomic diversification of life on Earth, yet remains underexplored due to culturing challenges. This study employed machine learning (ML) to predict symbiotic lifestyles in hundreds of thousands of microbial genomes fr...

Coronary Plaque Burden and Plaque Composition in Long-Term Cancer Survivors: A Comparative CCTA Study

Abstract Background The increased risk of atherosclerotic cardiovascular disease in cancer survivors is not fully elucidated. Understanding the coronary plaque burden and composition in survivors could address this gap. Objectives To determine whether cancer survivorship is assoc...

An edge AI‐powered power converter hardware platform for practical end‐to‐end AI‐to‐converter closed‐loop deployment

Abstract Modern power systems require increasingly flexible and responsive power conversion, driving the need for power converters with enhanced controllability and adaptability, where artificial intelligence (AI) plays a key role in enabling intelligent decision making, adaptive...