From prediction to mechanism: rethinking PTSD treatment non-response through an iron–inflammation framework

Abstract

Precision psychiatry has improved prediction of treatment response across psychiatry, but translating biomarkers into treatment strategy remains difficult. Using PTSD as a model, we outline an iron-inflammation framework linking treatment-predictive neural circuitry to an upstream biological mechanism, illustrating how neuroimaging may support biologically informed stratification and targeted adjunctive treatments.