University of Tübingen

Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism

Abstract Human reward processing varies along cue-centric and outcome-centric axes, but a reproducible mechanistic account of individual variation in incentive salience attribution has been lacking. Using fMRI across five cohorts (N-total=1,251; N1=890; N2=245; N3=34; N4=48; N5=3...

Joint Inversion of Seismic and Geoelectrical Data Targeting Geological Faults

Near-surface geological faults play a crucial role in subsurface systems because they influence fluid flow and transport and can cause geotechnical failure. Topography can sometimes indicate the presence of fault zones, particularly in active tectonic settings where geomorphic fe...

Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen species

Reactive oxygen species (ROS) promote genomic instability and fuel oncogenic signaling in cancer, but antioxidant therapies have so far failed to improve, or worsen, cancer outcomes. Emerging data suggest that T cells depend on ROS for signal transduction. In this study, we show...

Enhancing Agronomic Soil Functionality via Cover Cropping Management

This study aims to investigate the early post-termination phase as a critical window for assessing soil responses and improving agricultural management decisions. The experiment was conducted in Southern Italy and arranged as a split–split plot design involving three factors: irr...

Dystonia 3×3: A Training Guideline for Beginners in Botulinum Neurotoxin Treatment of Cervical Dystonia

Cervical dystonia (CD) is a hyperkinetic movement disorder characterized by involuntary muscle contractions leading to abnormal postures of the head and neck. The injection of botulinum neurotoxin type A (BoNT-A) into the muscles involved is the treatment of choice for CD. BoNT-A...

Integrated Study of the Distal Femur Biphasic Plate: Exploring In Vivo, In Vitro, and In Silico Methodologies

Abstract Purpose An emerging concept for plate fixation of fractured bones in humans changed from absolute stability through relative stability to a new concept of a predefined range of elastic movement with mechanical amplitude limitation (“Biphasic Plate,” 41 medical, Bettlach,...

9.4‐Tesla magnetic resonance imaging in focal epilepsy patients with high‐resolution surface‐based profiling of focal cortical dysplasias

Abstract Objective The detection of subtle epileptogenic lesions such as focal cortical dysplasias (FCDs) is a clinical challenge in the management of drug‐resistant focal epilepsy (DRFE). Ultra‐high‐field (UHF) magnetic resonance imaging (MRI) offers increased signal‐to‐noise ra...

Grand-Canonical Typicality

Abstract We study how the grand-canonical density matrix arises in macroscopic quantum systems. “Canonical typicality” is the known statement that for a typical wave function $$\Psi $$ Ψ from a micro-canonical energy shell of a quantum system S weakly coupled to a large but finit...

Selection of semiconducting metal oxides for light-activated gas sensors at low temperature

Abstract Light activation is a promising approach for lowering the power consumption and increasing the selectivity of chemoresistive gas sensors based on semiconducting metal oxides. In this study, different aspects of commonly used materials are investigated, compared, and eval...

Defining fever-related discomfort in children: an international Delphi consensus

Fever is one of the most common symptoms in childhood and a frequent reason for medical consultation. Current guidelines recommend treating fever only when discomfort is present. However, the concept of fever-related discomfort remains poorly defined and inconsistently applied in...

Complementary Indicators of Knowledge Purporting and Their Validity

Overclaiming (OC)—the tendency to claim knowledge one does not possess—is predominantly assessed through self-report Overclaiming Questionnaires (OCQs). However, exclusive reliance on OCQs raises concerns about mono-method bias, limiting our understanding of knowledge purporting...

Brugada Syndrome in the Pediatric Population: Diagnostic Challenges and Clinical Outcome—Results of the German Multicenter Study COGIA

ABSTRACT Introduction Diagnosis and treatment of children and adolescents with suspected Brugada syndrome (BrS) is challenging. Aim of the study was to evaluate the applicability of current diagnostic criteria for pediatric patients with suspected BrS in the German multicenter st...

Tricuspid-Valve Intervention in Heart Failure

BackgroundThe effect of transcatheter tricuspid-valve repair on clinical outcomes, including death and hospitalization for heart failure, in patients with severe tricuspid regurgitation remains uncertain. MethodsWe randomly assigned patients with symptomatic severe tricuspid regu...

Multimodal quantitative MRI finds early brain changes in asymptomatic X-linked adrenoleukodystrophy

Abstract Adrenoleukodystrophy (ALD) is an X-linked recessive disease caused by defects in the ABCD1 gene, leading to the accumulation of very long chain fatty acids in the nervous system, adrenal glands, blood, and other tissues. Male ALD patients may present with either the seve...

Lattice Dynamics Coupled at an Interface

A coupled lattice dynamical system generated by two infinite lattice differential equations meeting asymptotically at an interface is studied. This can be interpreted as a special case of dynamics on graphs with the sum of inputs and outputs at each node satisfying the Kirchhoff...

Geobacter metallireducens —evaluation of its sustainability in nitrate-reducing Fe(II) oxidation under autotrophic conditions

Abstract Bacterial nitrate (NO3−) reducing Fe(II) oxidation is often regarded as an autotrophic process, although its long-term sustainability is rarely demonstrated. Here, we assessed whether Geobacter metallireducens (ATCC 53774) can sustain chemolithoautotrophic nitrate-reduci...

Qualitative changes in binocular rivalry experience with age

Abstract Binocular rivalry is a visual phenomenon that occurs when two dissimilar stimuli are presented to each eye. The perception alternates between dominance periods when one of the stimuli is perceived with brief transition periods in between, providing a unique window into t...

Clinical and genetic characteristics of adult patients with familial Mediterranean fever at a German tertiary referral centre

Abstract Objective To characterise the clinical and genetic profile of adult familial Mediterranean fever (FMF) patients at a German tertiary referral centre and examine genotype–phenotype associations. Methods In this prospective single-centre registry study (October 2019–March...

Hidden in the clay. Unveiling the tradition of handmade pottery in Roman Thrace through an integrated analytical approach

Abstract Handmade pottery is among the most enduring yet least understood ceramic traditions of Roman Thrace. Long regarded as a simple household craft and primarily interpreted as a marker of local “Thracian” identity, it has rarely been examined as a dynamic cultural practice....

Legacy effects of subsoil compaction and earthworm biopores on soil hydrophysical properties and root density in a temperate silt loam soil

The short- and medium-term effects of agricultural soil compaction are well documented, but its long-term impacts and the role of biopores in subsoil recovery remain poorly understood. This study evaluated legacy effects of subsoil compaction on soil hydrophysical properties and...