University of Tübingen

Durable clinical and immunologic response to an off-the-shelf EWSR1–FLI1 peptide vaccine in metastatic Ewing sarcoma

Abstract Ewing sarcoma is a rare, fusion-driven malignancy with poor prognosis in the metastatic setting, for which no established immunotherapeutic treatment is currently available. Fusion breakpoints are rational precision immunotherapy targets, yet clinical evidence of immunog...

Identification and phenotypic profiling of subgroups with distinct cognitive aging trajectories

Cognitive aging is shaped by genetic variation, environmental factors, and health-related conditions. Until now, it is largely unclear why some individuals maintain their cognitive function, and others show progressive cognitive decline. This study uncovered determinants of disti...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

Enabling high-resolution wildlife tracking: antenna beam-based approach including novel per-position error estimations for automated radiotelemetry systems

Abstract Background The increasing importance of wildlife movement data in ecology and conservation has fueled the development of Automated Radiotelemetry Systems (ARTS) using very-high-frequency (VHF) transmitters. To make optimal use of this data, highly precise analysis method...

Blowing Leaves in Archaeology—The Multidimensionality of Technological Complexity in Human Origins Research

Abstract Technological complexity has been a continuous trope in archaeological research from its beginnings in the nineteenth century. Based on a concept of unidirectional cultural evolution, archaeological material was ordered along a linear progression from simple to complex....

Quantifying the Interplay Between PRAME Expression and Classical Morphology: A Multivariable Analysis of 954 Suspected Melanocytic Lesions

The integration of immunohistochemical biomarkers like PRAME (Preferentially Expressed Antigen in Melanoma) into the histomorphological assessment of melanocytic lesions is gaining prominence. While PRAME’s diagnostic value is widely recognized, its independent weight compared di...

A competency addition procedure for constructing minimal, yet maximally informative tests for skill assessment

Abstract Competence-based test development is a novel method for constructing tests that are as informative as possible about the competence state (the set of skills an individual possesses) underlying item responses. If desired, the tests can also be minimal, meaning that no ite...

Copper as a central element critical to interkingdom interactions within a polymicrobial wound environment

Abstract Staphylococcus aureus is a global health concern, estimated to cause over one million deaths each year. To colonise and survive in humans, S. aureus must overcome the host immune system and compete with other native and invading microorganisms. As a frequent coloniser of...