University of Tübingen

Spatial transcriptomics profiling across tissue boundaries in the developing mouse brain

Tissue boundaries preserve structural integrity and guide cell differentiation during development, despite constant stress from proliferation, cell death, and tissue deformation. To study gene regulation in these regions we developed REBOSEP, a workflow for analyzing spatial tran...

Clinical management of metachromatic leukodystrophy cases identified in the German and Austrian Newborn screening pilots

Abstract Background Metachromatic leukodystrophy (MLD) is a rapidly progressive leukodystrophy that leads to severe disability and early death if untreated. Autologous hematopoietic stem and progenitor cell gene therapy (HSPC-GT, atidarsagene autotemcel, arsa-cel) for early onset...

Affective Profiles of Figurative Language: Cognitive and Computational Insights

Abstract Figurative language is a powerful means of expressing complex emotions and thoughts. This study examines how different types of figurative language relate to emotion by analyzing metaphors, similes, idioms, and sarcasm with four BERT-based emotion classification models t...

Gut resilience and clinical homeostasis following administration of neomycin and albendazole in soil-transmitted helminth-infected adults living in Lambaréné, Gabon

Abstract Purpose Gut resilience and systemic homeostasis are interrelated dynamic functions. A gut that fails to regulate intestinal barrier integrity, metabolite production, and immune regulation will lead to systemic pathogenic invasion and susceptibility to infections. Gut res...

Fathoming Synthesis Strategies for Rare-Earth-Metal Trimethyl Compounds

Abstract The synthesis of alkali-metal-free compounds [LnMe3]n is scrutinized using two distinct protocols. The donor-promoted cleavage of homoleptic tetramethylaluminate complexes Ln(AlMe4)3 proves rare-earth metal (Ln) size-dependent and gives access to [LnMe3]n (small to midsi...

Tales of “Good Indian Hair”: Race, Value, and Sensory Contact Zones in Afro‐Asian Delhi

ABSTRACT Hair, as a sociocultural bodily signifier, also becomes, once disembodied, a highly globalized and specialized commodity used for weaves, extensions, wigs and toupees around the globe. “Indian” hair is particularly valued in such commodity chains. Consequently, several m...

Attractor dynamics underlie sequence working memory in data-constrained recurrent neural networks

Sequences of stimuli can be maintained in working memory by encoding each item, together with its position, as a distinct pattern of neural population activity. Competing hypotheses about the underlying dynamics have been proposed: patterns of activity might be supported either b...

Distribution and voltage dependence of ion channels shape single-neuron computations

Voltage-gated ion channels do not distribute evenly in the plasma membrane of a neuron; they localize to distinct domains where they govern the excitability of the cell and the computations it performs. Informed by electron microscopic reconstructions, models of morphologically r...

Austro-Marxism and the Habsburg Crisis: A Non-Territorial Response to the Conflict of Governance and Class

This article re-examines the national theory of Austro-Marxism as a response to the dual crisis of the late Habsburg Empire: the paralysis of imperial governance and the erosion of cross-national class solidarity. Karl Renner and Otto Bauer proposed a non-territorial federal sche...

Insulin Resistance in the 21st Century: New Takes on an Old Problem—2025 Diabetes , Diabetes Care , and Diabetologia Expert Forum

Insulin resistance is a hallmark of type 2 diabetes and several other metabolic diseases. However, efforts to improve insulin resistance are hindered by the biological complexity inherent to insulin action, as well as conceptual and methodological limitations to date. In Septembe...

MRI-derived prostate volume assessment: manual segmentation versus two-axis ellipsoid approximation and its implications for PSA density

Abstract Purpose To evaluate how accurately prostate volume estimated with the ellipsoid formula matches manual segmentation (reference standard) and to assess whether an individualized, volume-dependent adjustment of the ellipsoid weighting factor improves performance. Methods I...

Insulin resistance in the 21st century: new takes on an old problem—2025 Diabetes, Diabetes Care, and Diabetologia Expert Forum

Insulin resistance is a hallmark of type 2 diabetes and several other metabolic diseases. However, efforts to improve insulin resistance are hindered by the biological complexity inherent to insulin action, as well as conceptual and methodological limitations to date. In Septembe...

cGMP Signaling in Arterioles Revealed by FRET ‐Based Real‐Time Measurement in Mice In Vivo

ABSTRACT cGMP evokes arteriolar vasorelaxation and is generated in smooth muscle by the soluble guanylyl cyclase (sGC) stimulated by endothelial NO. Phosphodiesterases (PDEs) degrade cGMP and may contribute in diameter regulation. We examined arteriolar cGMP levels in real‐time i...

Evaluation of an image-derived input function and population-based metabolite correction for quantification of synaptic density with [18F]SynVesT-1 and PET in male and female rats

Positron emission tomography (PET) quantification of radiotracers targeting synaptic vesicle glycoprotein 2A (SV2A), such as [ 18 F]SynVesT-1, requires arterial blood sampling and metabolite analysis to derive an arterial input function (AIF). However, arterial blood sampling is...

Afghanite: A New Silicate‐Matrix Reference Material for In Situ Halogen and Sulfur Microanalysis

Sulfur (S) and the halogens (F, Cl, Br, I) play key roles in geochemical processes that govern volatile cycling, redox evolution, phase reactions and ore formation in the Earth's crust and mantle. Quantifying these elements in situ requires well‐characterised reference materials...

Clinical Global Impression-Stimulation Outcome Monitoring Tool (CGI-STIM): development and preliminary evaluation of a pragmatic clinical rating tool for electroconvulsive therapy

Abstract Objectives Electroconvulsive therapy (ECT) is highly effective for severe and treatment-resistant mental disorders, but concerns about cognitive side effects and enduring stigma continue to hinder its broader acceptance. Although treatment response and cognitive tolerabi...

Bilateral theta burst stimulation as an add-on to schema therapy in major depression: methods and design of a randomized, sham-controlled study

Abstract Schema therapy (ST) is an integrative psychotherapeutic treatment that may be as effective as cognitive behavioural therapy in treating depression. Novel approaches are focusing on augmenting psychiatric treatments with brain stimulation techniques, like repetitive trans...

State-of-the-art electroweak Higgs boson pair production in association with two jets at the LHC in the Standard Model and beyond

We present a systematic comparison of two state-of-the-art tools for the simulation of Higgs boson pair production via vector boson fusion (VBF) as implemented in the Monte- Carlo tools GoSam+Whizard and the POWHEG-BOX. The comparison is carried out at LO and NLO-QCD in the SM an...

The Role of Age and Instruction in Children's Learning of Vocabulary and Grammar

Abstract It is generally assumed that children and adults learn language through fundamentally different mechanisms: Children predominantly rely on implicit learning, and adults utilize more explicit strategies (Lichtman, 2016). However, little is known about when and how learner...

Provenance and exchange networks of Mycenaean pottery from Tell Atchana/Alalakh, Southern Türkiye: A comparative ICP-MS and petrographic investigation

This paper presents the results of Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and petrographic analyses conducted on Mycenaean pottery assemblages—specifically Late Helladic (LH) IIIA2 and LH IIIC-style ceramics—recovered from the Late Bronze Age II and Early Iron Age...