University of Tübingen

Dirac wave functions of positive energy with arbitrarily small position uncertainty

Abstract We consider wave functions in the Hilbert space H=L2(R3,C4) of a single Dirac particle, specifically from the positive-energy subspace H+ of the free Dirac Hamiltonian. Over the decades, various authors hypothesized that for wave functions from H+, there is a positive lo...

ViTAMIn‐O: Democratizing Computer Vision‐Based Machine Learning for Stem Cell Research

Deep Learning (DL) holds exciting potential in automating the prediction of organoid differentiation results. Nevertheless, current models lack adaptability, openness, and robustness in performance. Additionally, broad employments of predictive models in wet‐lab settings necessit...

Preparing surgery for Generation Z - Motivation and protective factors for pursuing a surgical career among medical students and early-career physicians: a cross-sectional study

Abstract Background Surgery is facing a substantial shortage of young professionals. In particular, it has become increasingly difficult to attract medical students, especially women, to pursue a surgical career, although women currently represent the majority of medical students...

A multicenter randomized, double-blinded placebo-controlled phase 2 trial to evaluate safety and efficacy of ilofotase alfa in patients at risk for kidney injury following open heart surgery

Acute impairment of kidney function after cardiac surgery is common and associated with an increased morbidity and mortality. Ilofotase alfa has demonstrated potential to attenuate renal injury through its immunomodulatory effects. We evaluated the safety and efficacy of ilofotas...

Misinformation as an Event-Model Problem

Why does misinformation continue to influence reasoning even after it has been corrected? Dominant accounts treat this persistence as a failure of belief updating, emphasizing propositional acceptance, motivational resistance, or memory decay. We argue that this view overlooks a...

Reactivity-Guided Detection Strategies for Isocyanide Natural Products Reveal Acid-Induced Hazimycin Artifacts

Abstract Isocyanides are unusual functional groups with important roles in synthetic chemistry, chemical biology, and natural product bioactivity, but their detection in complex biological samples remains challenging. Here, we developed complementary HPLC-MS- and fluorescence-bas...

Perspectives of High‐Resolution Mass Spectrometry in Soil Science

ABSTRACT Soil biogeochemical research requires specific, sensitive, and accurate methods to identify and quantify organic molecules in order to trace biochemical processes and assess element cycling in complex, heterogenous systems. High‐resolution mass spectrometry (HRMS) has ev...

A tropical version of Martens' theorem for metric graphs

Abstract We study the conjecture stated by Jensen and Len on a tropical version on Martens' theorem via the Brill–Noether rank of a tropical curve. We recall Coppens' counterexample of Martens‐special chain of cycles, and we generalize the construction defining another class of g...

Increased firing rates monotonically expand neuronal coding bandwidth

Sensory information is often processed by populations of neurons that vary with respect to their levels of spiking activity. It appears plausible that neurons that fire more often are capable of following faster changes in the input signal than those with lower firing rates. In t...

A high-resolution, multi-method palaeoenvironmental record from pan sediments at Maralaleng Pan, southern Kalahari basin

Human traces in semi-arid environments such as the Kalahari have been linked to the presence of water in the landscape. However, low organic preservation and an uneven distribution of studied sites have resulted in a gap in the knowledge of the environmental conditions under whic...

Who benefits from an imperative?

Abstract The distribution of benefits associated with a projected future action has been considered important in determining the type of directive expressed by an imperative. However, there has been little research on how speakers perceive the beneficiary of future action in impe...

Adaptations to breath-hold diving: from traditional divers to elite athletes

Breath-hold diving exposes humans to repeated episodes of profound hypoxia and hypercapnia, eliciting physiological adaptations that enable prolonged underwater performance. This article summarises current knowledge on chronic adaptations in elite breath-hold athletes and traditi...

Expanding the genotypic and phenotypic spectrum of PGAP1 deficiency: clinical and functional insights from 15 patients

Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are essential for neuronal development, synaptic organization and signaling. Defects in GPI-anchor biosynthesis or remodeling cause rare neurodevelopmental disorders, including post-GPI attachment to proteins 1 (PGAP1) defi...

A systematic review of ultrasound to predict severe disease in patients with dengue and other viral infections associated with hemorrhagic fevers

Background Viral infections associated with hemorrhagic fevers (VaHFs) cause millions of cases each year across a broad geography with severity ranging from asymptomatic cases to clinical disease with a high case fatality rate. Commonalities in pathophysiology across VaHFs includ...

Multispecies Justice Through Interspecies Deliberation

In this paper, we argue that multispecies justice should be able to integrate diverse ontologies, especially relational ontologies that emphasize relationships between human and more-than-human beings. After reviewing three existing accounts, we develop an approach to interspecie...

Systemic administration of the mGluR2/3 antagonist LY341495 disrupts reward-related behaviors across ingestive and social domains in mice

Metabotropic glutamate 2/3 receptors (mGluR2/3) have been implicated in depression, anxiety, learning, and memory, yet their role in reward-related behavior remains poorly understood. Here, we examined the effects of the selective mGluR2/3 antagonist LY341495 on reward-related be...

Efficacy, safety and circulating tumor cell dynamics in patients treated with Eribulin for HER2-negative advanced breast cancer – results from the phase II DETECT IVb trial

Abstract Background Eribulin is a non-taxane microtubule inhibitor that showed survival benefits for pretreated metastatic breast cancer (MBC) patients. Circulating tumor cells (CTCs) are a prognostic marker, but their role in predicting response to specific MBC treatments is les...

Generative debunking of climate misinformation

Abstract Misinformation is a persistent roadblock to progress on climate change, and the ubiquitous, rapid spread of misinformation means that manual solutions are inadequate to meet the scale of the problem. While many studies have developed methods for automated detection of mi...

p53—Oncogene, Tumor Suppressor Gene, Guardian of the Genome and the Cell

More than four decades after its discovery, p53 remains a central regulator of cellular homeostasis and one of the most extensively studied proteins in cancer biology [...]

Towards and beyond the ‘Fall’: rethinking Rome’s end

Knöpges, Ellen Muehlberger, and the three anonymous reviewers for their inspiration, helpful suggestions and critique.We particularly thank Neville