University of Oxford

MicroRNA 517a-3p suppresses α-synuclein fibril accumulation in human glioblastoma cells

Abstract Background Synucleinopathies are a group of neurodegenerative disorders characterized by the misfolding, aggregation, and accumulation of α-synuclein (α-syn) into oligomeric assemblies and amyloid inclusions. Alongside neurons, glial cells can internalize pathological α-...

Multilevel lattice-based kernel approximation for elliptic PDEs with random coefficients

Abstract This paper introduces a multilevel kernel-based approximation method to estimate efficiently solutions to elliptic partial differential equations (PDEs) with periodic random coefficients. Building upon the work of Kaarnioja, Kazashi, Kuo, Nobile, Sloan (Numerische Mathem...

Money, So Much Money: Reading Tahel Frosh’s Avarice

In this article, I address the work of the Israeli poet Tahel Frosh, whose debut collection Avarice (2014) advances a critical commentary on neoliberalism and the privatization of the Israeli economy. Against official accounts of Israel’s economic history and their emphasis on de...

Money on My Mind: Stein’s Meditations

This essay looks at Gertrude Stein’s fraught relationship with money across her career, from the strong ethical importance that she attached to it in her early prose through to her crisis of value after the success of The Autobiography of Alice B. Toklas. Focusing on her 1932 lon...

Associations between maternal age at first birth and parenting behaviour among migrant and displaced mothers on the Thailand-Myanmar border

Background Early parenthood is an established risk factor for poor maternal and child outcomes. Research on the association between maternal age at first birth and parenting behaviour remains limited in displacement contexts in low- and middle-income countries, despite the high p...

Spike antibody Fc is associated with protection from SARS-CoV-2 challenge in macaques

A definitive correlate of protection (CoP) for SARS-CoV-2 has yet to be formally established. We previously reported that neutralising antibodies (NAbs) are the strongest candidate CoP for clinical protection against COVID-19 and that spike binding antibody is the strongest candi...

Poetic Currency: A Poetry Dossier

Across centuries and languages, poets have articulated the power of capital in their lives—how it exerts control over bodies and homes, and how it determines the visibility, circulation, and exchange of texts. This dossier offers a collection of world poetry that addresses money,...

Migratory dermal γδ T cells determine the balance between lung immunity and tissue damage during helminth infection

Many helminth parasites migrate through multiple host organs during infection, but how immune responses are relayed across these tissues is still poorly understood. To investigate the immune aspects of intertissue communication during infection, we established a percutaneous infe...

Re-evaluating molecular clock maximum age calibrations revives pre-Ediacaran divergence estimates for animals

Divergent models persist for the emergence of animals. Lipid biomarkers suggest animals originated before 635 million years ago (Ma), but their body fossil record extends to only 574 Ma. Molecular clocks might differentiate between these records, but we demonstrate how their accu...

International Modified Delphi Consensus on Assessment and Management of Covert Brain Infarction

BackgroundCovert brain infarction (CBI) is a frequent incidental neuroradiological finding increasingly recognized as clinically relevant due to its association with stroke, cognitive decline, and other adverse outcomes. However, substantial uncertainty remains regarding its opti...

An etiological approach to psychosis: potential benefits for treatment, research and prevention.

Current treatment of psychosis focuses on antipsychotic medication, and rarely addresses the factors that have contributed to the onset and persistence of the disorder. We suggest that the most useful way of facilitating treatment, research and prevention is to identify the causa...

A multimodal manual therapy, exercise, and psychological intervention for painful diabetic neuropathy: the NeuOst feasibility randomised controlled trial.

Introduction: People with painful diabetic neuropathy lack effective and tolerable treatments. Physical and psychological interventions may help but require further study and combination to maximise effects. Objectives: This single-site, 3-arm, parallel, randomised feasibility tr...

Top-Down = Bottom-Up: Sound and Complete Characterisations of Liveness by Multiparty Global Protocols

Multiparty session types (MPST) are a type discipline for concurrent and distributed systems, designed to ensure not only type safety and deadlock-freedom, but also liveness of typed communicating processes. Two main MPST methodologies, top-down and bottom-up, have been proposed...

Evidence-based atlas of risk and protective factors for psychotic disorders: an umbrella review to inform personalized prognosis and prevention.

Identifying updated, evidence-based risk and protective factors for psychotic disorders is essential to advancing scientific and clinical knowledge of their etiology. Since the most recent umbrella review published in this journal, the evidence base has expanded substantially. Fo...

Validation of the European Bone & Joint Infection Society recommendations for debridement, antibiotics, and implant retention in hip and knee periprosthetic joint infection

Aims The aim of this study was to externally validate the European Bone & Joint Infection Society (EBJIS) recommendations for the use of debridement, antibiotics, and implant retention (DAIR) in the treatment of periprosthetic joint infection (PJI), examining the independent asso...

Generalized Nonlinear Bayesian Pulsar Timing with ENTERPRISE

Abstract We use the Bayesian methods in the ENTERPRISE package to examine the fully general parameterization of pulsar timing models in tandem with noise. We investigate four pulsars, PSRs J1600–3053, J2043+1711, J0740+6620, and J1640+2224, through the lens of Bayesian timing. We...

Quantum fluctuations in hydrodynamics and quantum long-time tails

We construct a quantum Schwinger-Keldysh (SK) effective field theory for the diffusive hydrodynamics of a conserved scalar field. Quantum corrections within the SK framework are guided by fluctuation-dissipation relations, enforced via a dynamical Kubo-Martin-Schwinger (KMS) symm...

Numerical simulations of simultaneous pair-drop impacts and their energetics

Single drop impacts have been extensively studied, but frequently in practice, adjacent droplets may impact in close proximity and thereby interact with one another. This interaction is characterised by the appearance of a lamella arising from the collision of the two droplets’ s...

Housework, hygiene and health. Public expectations versus private limitations in working-class households in late-nineteenth and early-twentieth–century Britain

Economic historians often attribute better health and hygiene in the late-nineteenth and early-twentieth centuries to improved domestic conditions, enabled by sanitary reform and the education of working-class women in household management. Instruction might have engendered a new...

Time symmetry in quantum theories and beyond

There exists a stark tension among different formulations of quantum theory as some are inherently time-symmetric while others are time-asymmetric. This tension is crisply captured when considering physical theories as theories of processes. We present the process theory of quant...