University of Oxford

Multiple motor proteins regulate TDP-43 anterograde axonal transport

TAR DNA-binding protein 43 (TDP-43) is an RNA-binding protein essential for RNA metabolism. Under physiological conditions, it predominantly resides in the nucleus but is also expressed in the cytoplasm, where it regulates mRNA trafficking and local translation. In nearly 97% of...

Broad multiplex respiratory panel implementation and antibiotic prescribing in US emergency and urgent care departments: a staggered-adoption study

Abstract Objective: To evaluate the association between department-level implementation of broad multiplex respiratory pathogen panels and antibacterial prescribing. Design: Retrospective repeated cross-sectional staggered-adoption study with cohort-stacked difference-in-differen...

Efficacy and safety of intraoperative red blood cell salvage transfusion for spinal deformity surgery: a systematic review and meta-analysis

Spinal deformity surgery is associated with substantial blood loss and high transfusion requirements, exposing patients to the risks of allogeneic blood transfusion. Intraoperative cell salvage (ICS) is widely used in patient blood management strategies, yet its clinical efficacy...

Disability inclusion for just transitions: A semi-systematic review of representations of persons with disabilities in energy transition research

Transitions to low-carbon energy systems risk perpetuating existing social inequalities if they fail to account for marginalised groups. Persons with disabilities are often overlooked in energy policy and research, despite having distinct and often greater energy needs, requiring...

Remarks on non-invertible symmetries on a tensor product Hilbert space in 1+1 dimensions

We propose an index of non-invertible symmetry operators in 1+1 dimensions and discuss its relation to the realizability of non-invertible symmetries on the tensor product of finite dimensional on-site Hilbert spaces on the lattice. Our index generalizes the Gross-Nesme-Vogts-Wer...

Lessons from the history of antipsychotic discovery: part 3 - muscarinic mechanisms.

After more than seven decades in which antipsychotic drug development has been dominated by dopaminergic mechanisms, the recent emergence of a muscarinic receptor-based treatment represents a conceptual shift in the pharmacotherapy of psychosis. This article reviews the history a...

Social processes in well-being (SoWell): A survey and ecological momentary assessment twin study

Aims : The Social Processes in Well-being (SoWell) study is an intensive longitudinal twin study designed to examine the relationships between mental health and social and environmental factors over time and to address the genetic contribution to these associations. Methods : App...

Considering Culinary Use of Lavender: Sensory and Cultural Factors

Lavender is a Mediterranean herb that is used relatively infrequently in the kitchen compared to other Mediterranean herbs, despite growing interest in its culinary applications. The question to be addressed in this narrative historical review is why that should be so. Several al...

Lessons from the history of antipsychotic discovery: part 1 - initial insights.

The recent introduction of the first non-dopaminergic antipsychotic marks a pivotal moment in psychopharmacology. This article revisits the development of chlorpromazine, the world's first licensed antipsychotic, and considers what its history reveals about innovation in psychiat...

The AML-Associated A338V Mutation Rewires GPR183 Signaling through C-Terminal Ensemble Redistribution

Abstract G protein–coupled receptors (GPCRs) rely on dynamic conformational ensembles to coordinate G protein activation and recruitment of regulatory transducers such as GPCR kinases and β-arrestins. The oxysterol receptor GPR183 has been implicated in hematological malignancies...

Teaching the past, informing the present? School history education and attitudes toward foreign countries

Abstract How does school history education emphasizing past grievances with other countries impact attitudes toward conflict and cooperation with the countries today? We examine this question using original data from 34 classrooms across 17 high schools in Seoul, South Korea. We...

Analytical Prediction of Critical Transitions in Oscillator Networks With Non‐Local Links

ABSTRACT A wide range of dynamical systems can be modeled as oscillators coupled through an interaction network. Such frameworks have been widely used to explore the emergence of collective phenomena across diverse applications. Here, we develop an analytical framework for oscill...

Lessons from the history of antipsychotic discovery: part 2 - dopaminergic diversification.

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Development and Validation of a Tool to Measure Documented Health Care Encounter Time

Importance Time toxicity, defined as the time patients spend receiving cancer treatment and interacting with health care systems, is an emerging treatment-related burden. Existing studies typically quantify time toxicity using health care contact days, which may inadequately capt...

The Limits of Regionalism in Achieving Effective Spatial Outcomes

Abstract Institutional quality matters and decentralisation and regionalisation should be in service of this overall aim. This paper, in putting forward this simple proposition, lays out evidence on regionalisation, decentralisation and institutions. Despite an assumption that th...

Making Shrimp in Moral Economies: Time, Ethics, and Labor in a Global Supply Chain

ABSTRACT This article is part of the special issue 'Morality at Work: Ethnographies of Labor and Ethics' edited by Michael Vine and Sarah Winkler‐Reid. This article explores how future‐oriented temporalities shape people's labor experiences and ethical subjectivities within the g...

Brief internet intervention for grieving children and adolescents: co-design and trial protocol

ISRCTN.org identifier: ISRCTN21132251.

A fast radio burst at redshift 2, three billion years after the Big Bang

Fast radio bursts (FRBs) are millisecond-duration radio transients from extragalactic sources. Their frequency and polarization properties are affected by plasma and magnetic fields along the line of sight to Earth. We report radio observations of FRB 20240304B and near-infrared...

Breaking the Blend: A multi-tracer kinematic decomposition method for IFS data applied to disentangling the AGN outflow and circumnuclear ring in NGC 5728 with JWST

Abstract Integral field spectroscopy (IFS) of the central kiloparsecs of active galactic nuclei (AGN) reveals a mixture of spatially coincident emission from star-formation and AGN feedback exciting the interstellar medium. Disentangling these components remains a challenge, as m...

Where is the evidence? A global systematic review of sanitation system resilience to climate hazards

Despite sustained efforts over several decades, no region is projected to achieve universal sanitation access by 2030, according to international monitoring frameworks. Climate change is increasingly disrupting human and ecological systems, in turn deepening existing inequalities...