University of Oslo

Augmentative and Alternative Communication and Language: Some Old and New Urgent Issues

Some children struggle with speech development and a small minority never achieve intelligible speech. This review explores research on the use of augmentative and alternative communication (AAC) to support their development of communication and language. There is no generally ac...

The paracrine Ephrin A4/BMP4 feed-forward loop sustains a tumor–CAF vicious cycle in osteosarcoma

Abstract Background Advanced osteosarcoma (OS) remains a clinical challenge due to its aggressive behavior and poor prognosis. Cancer-associated fibroblasts (CAFs) have been shown to contribute to tumor progression, but the tumor–CAF crosstalk in OS is still poorly defined. Eluci...

Variation in general practitioners’ mental health diagnostic tendencies and subsequent patient care: a Norwegian registry study

Abstract Background General practitioners (GPs) are often the first point of contact for adults presenting with symptoms of depression or anxiety. Practices may vary due to patient and physician tendencies, influencing treatment pathways. This study aimed to quantify variation in...

Interferometric Vector Piezoresponse Force Microscopy for Simultaneous Ferroelectric Domain and Crystallographic Orientation Mapping in Uniaxial Ferroelectric Polycrystals

ABSTRACT Ongoing advances in scanning probe microscopy techniques are continually expanding the possibilities for nanoscale characterization and correlated studies of functional materials. Here, we demonstrate how a recent extension of piezoresponse force microscopy (PFM), known...

Obstetric Factors Associated with Pelvic Floor Disorders and Surgery 30 Years After Childbirth: A Prospective Cohort Study

We aimed to compare symptoms of pelvic floor disorders (PFDs) and surgery risk by mode of delivery 30 years after first childbirth and assess symptom changes over time. We also examined associations between PFDs and pelvic floor muscle injuries. Prospective cohort study in 2024 o...

Sex differences in dementia with Lewy bodies: a systematic review

Abstract Sex differences are increasingly recognized across neurodegenerative disorders, including Dementia with Lewy Bodies (DLB). Despite ongoing refinement of diagnostic criteria, DLB remains frequently misdiagnosed—particularly among females—reflecting gaps in our understandi...

Ordinal patterns with ties and tolerance provide a physiology-driven method to quantify cardiorespiratory interactions

We propose a new analytical approach based on ordinal pattern analysis to investigate respiratory heart rate variability (RespHRV, also called respiratory sinus arrhythmia), specifically modulation of heart rate across different phases of the respiratory cycle. The method uses RR...

Robust inference and correlates from genetic associations with personality

Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustne...

Wellbeing, mastery and work participation: Effects of the Five Ways to Wellbeing course—a randomized controlled trial

Background: Rising ill health, declining wellbeing, and absenteeism threaten societal sustainability amid an ageing population. Promoting health, wellbeing and work participation is essential. The Five Ways to Wellbeing course is a six-week programme designed to enhance wellbeing...

CT sinus imaging utilization in Norway: trends over time and variation by region, age, and sex

Abstract Background Computed tomography (CT) of the sinuses is a standard component of radiological diagnostics. CT of the sinuses are often regarded as low-value care owing to their minimal impact on disease management. The aim of this study is to describe geographical and tempo...

Extended D3 Mesenterectomy in Small Bowel Cancer Treatment: Feasibility and Importance for Staging. First Results of a Prospective Clinical Trial

ABSTRACT Background There is no consensus on surgical techniques in small bowel cancer, particularly regarding the extent of lymph node dissection and strategic choices according to tumor localization and histological type. Clearance of central lymph node metastases can be challe...

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Abstract Background Cyclin-dependent kinases drive the progression through the cell cycle and thereby form classical targets for cancer therapy. In prostate cancer (PC), the first line of therapy typically targets androgen receptor (AR), but it frequently leads to development of...

Toddlers show heightened attention to selective distributors

We investigated whether Norwegian 21-month-olds (N = 176) hold expectations about agents' dominance based on their distributive fairness (data collected during 2021–2024). Toddlers were presented with two agents who first distributed resources, one acting evenly/fairly and the ot...

Patients’ Mental Barriers in Rehabilitation after ACL Reconstruction: A Qualitative Interview Study

Background Recovery after anterior cruciate ligament reconstruction (ACLR) involves both physical and psychological challenges. Although psychological readiness for return to sport (RTS) is increasingly recognized as important, less is known about how patients experience psycholo...

Blogs as Dialogical Reparatory Work: A Theoretically Informed Analysis of Online Cancer Narratives

Globally, the World Health Organization (WHO) estimates that there are 20.6 million new cancer cases each year, and its incidence is expected to rise as the global population ages. At the same time, new technologies and advanced treatments are increasing survival rates, particula...

Multi-modal learning with incomplete data

Multi-modal learning, in which diverse data types are integrated and analyzed together, has become a central area of research in artificial intelligence, driving major advances in a wide range of domains. However, in many practical situations, certain modalities or variables may...

An Explanation for Dreaming Based on Neuronal Maintenance

Nighttime dreams are an interesting phenomenon. Investigations have moved from attempts to interpret their content to seeking a biological function. In both cases, it has proven difficult to obtain convincing answers. I shall argue that dreams are the consequence of a requirement...

Lipoprotein(a) and Atherosclerotic Cardiovascular Disease Among Adults Aged 20 to 100 Years

BACKGROUND: High lipoprotein(a) is considered a causal risk factor for atherosclerotic cardiovascular diseases (ASCVD); however, whether the association between lipoprotein(a) and ASCVD is different among older individuals (defined as 70–100 years of age) compared with younger in...

Digital practices in CLIL across Romance- and Germanic-language contexts: a teacher survey with complementary student data

Research on digital practices has grown substantially thanks to recent technological advancements. Using data from the COST Action CA21114 Digital Literacies Teacher Survey (DLTS) and Student Survey (DLSS), where Content and Language Integrated Learning (CLIL) classrooms are focu...

Context-dependent localization and expression of glutamate and GABA and their machinery in microglia

Microglia are central regulators of brain homeostasis and synaptic architecture, but whether they, like astrocytes, act as reservoirs and handlers of glutamate and GABA is unknown. Using post-embedding immunogold electron microscopy, we provide the first ultrastructural evidence...