University of Oslo

Comparison of CT-based migration analysis against radiostereometric analysis for assessing two-year migration in an uncemented medial pivot tibial knee implant

Aims: Radiostereometric analysis (RSA) is the gold standard for migration analysis of orthopaedic implants, but CT-based RSA has shown comparable results in an increasing number of joints. In this study, we compared the method in an uncemented medial pivot tibial implant. Our pri...

Feasibility and acceptability of including advance care planning in a home-based palliative-care coordination meeting: a longitudinal ethnographic study of the experiences of older patients, their relatives and healthcare professionals

Abstract Background Advance care planning provides a structured approach to conversations about values and preferences but is uncommon in clinical practice. We implemented advance care planning as routine at the initiation of an individually tailored palliative care pathway in No...

Initial treatment strategies and outcomes across haemodynamic thresholds and risk stratification in incident systemic sclerosis–associated pulmonary arterial hypertension: a EUSTAR analysis

OBJECTIVE: Real-world initial treatment strategies in SSc-PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. METHODS: We analysed treatment-naïve SSc-PAH patients in EUSTAR...

ERGA-BGE reference genome of the bladderpod Alyssoides utriculata (L.) Medik. (Brassicaceae), a yellow-flowering shrub native to Switzerland

We present the chromosome-level genome assembly for bladderrpod, Alyssoides utriculata (Brassicales: Brassicaceae), the only currently accepted species in the genus Alyssoides. The phased assembly comprises two haplotypes with total lengths of 1.01 Gb and 0.98 Gb, respectively. F...

Locomotion and hunting strategies of large vertebrate predators in pelagic waters

Abstract Many of the key dynamics that shape predator–prey interactions are governed by the physical and physiological principles which determine how animals move and perform in their environments. This opinion paper outlines the foundations underlying marine vertebrate predator–...

Reframing “One Health” for Healthcare-Associated AMR: Target Microbes, Internal Environments, and Operational Action

While the One Health paradigm has successfully elevated antimicrobial resistance (AMR) on the global political agenda, its operationalization raises questions about how research, surveillance and interventions can best address transmission in healthcare settings. In this perspect...

The effect of being assigned to special needs assistance depends on children's types of difficulty

This study examines the effects of being assigned to special needs assistance (SNA) and children's difficulty types ( n = 35,024; 1809 received SNA) in early childhood education and care (ECEC) on children's language and academic skills in primary school. Using the Norwegian Moth...

Validation of a Pre-CS1 Concept Inventory

As programming has become a prominent component of K–12 education in large parts of the world, incoming university students increasingly enter higher education with prior programming experience. To inform instructors of how far students have already progressed into the introducto...

Ets2 Is an Activity‐Dependent Transcriptional Regulator of a Fast‐Twitch Muscle Program

The functional properties of excitable cells, including skeletal muscle, are regulated by electrical activity. Distinct motoneuron firing patterns control contraction speed, strength, and endurance of fast- and slow-twitch myofibers by activating transcriptional programs that spe...

In Vitro and In Vivo Efficacy of the Broad-Spectrum β-Lactamase Inhibitor APC24-7 in Combination with Meropenem Against Carbapenem-Resistant Enterobacterales

Background: Carbapenem-resistant Enterobacterales (CRE) represent a major therapeutic challenge, driven in part by serine β-lactamases (SBLs) and metallo-β-lactamases (MBLs). APC24-7 is a broad-spectrum β-lactamase inhibitor (BLI) designed to inhibit enzymes from both groups. Her...

Sociodemographic, Criminological and Clinical Determinants in Suicide After Release From Prison: A 23‐Year National Cohort Study

ABSTRACT Background Suicide risk is elevated after prison release, but population‐level evidence on temporal risk patterns and associated factors remains limited. We aimed to describe characteristics of individuals who die by suicide after release from Norwegian prisons, compare...

Zonation Hallmarks in Human PSC‐Derived Hepatic Organoids Integrated into an Immune‐Compatible Organ‐on‐Chip for Liver Injury Modeling

ABSTRACT Liver metabolic zonation enables hepatocytes to carry out diverse, spatially organized functions essential for liver homeostasis and metabolism. However, in vitro recapitulation of zone‐specific diversity, particularly in human pluripotent stem cell (PSC)‐derived hepatoc...

Optimising indicated prevention for child anxiety and depression: A 12-month follow-up for cluster-randomised factorial 2 x 2 x 2 trial

Background: Early intervention can reduce the burden of internalising problems for children and adolescents, yet access remains limited. The field must ensure preventive interventions that are both durable and scalable. One promising approach is developing interventions that are...

Bridging policy and implementation science: operationalising political and structural determinants for health policy implementation evaluation

Abstract Background Despite their critical role in shaping public health policy implementation, key political and structural determinants within implementation frameworks are often poorly defined, underreported, or treated as background rather than as core implementation variable...

ADHD symptoms and learning difficulties: co‐occurrence and directionality from Grades 1 to 9

Background Children with attention‐deficit/hyperactivity disorder (ADHD) are at increased risk of learning difficulties. This association may reflect shared risk factors, ADHD symptoms hindering learning, or learning difficulties increasing ADHD symptoms. We aimed to map rates of...

Seasonal presence, movements and behaviour of Atlantic cod ( Gadus morhua ) in Isfjorden, Svalbard

Abstract Atlantification is increasing the inflow of warm, salty Atlantic water into the Arctic region. The fjords on the western coast of Svalbard are experiencing Atlantification, enabling boreal species, such as Atlantic cod ( Gadus morhua ), to expand their distribution north...

Hurried science and the tracking problem

In times of crisis, science tends to move fast. However, speeding up science often involves deliberate compromises to the scientific norms that are meant to guarantee the reliability of scientific results in normal circumstances. Call this hurried science. Some of the compromises...

Hydrogenation of CO2 to Propane and n -Butane by Engineering Metal Oxide Interfacial Structure and Manipulating Zeolite Pore Structure and Acidity

Abstract Selective hydrogenation of CO2 to propane and n-butane is of great interest, as these two compounds are not only primary components of liquefied petroleum gas (LPG) but also crucial raw materials for preparing propene and a degradable plastic precursor of succinic acid....

A phosphoinositide and RAB switch controls early macropinocytosis

Macropinocytosis is a non-selective endocytic process by which cells take up large amounts of extracellular fluid into giant vesicles known as macropinosomes. This mechanism is used by immune cells to sample the surroundings for antigens and can be exploited by cancer cells for n...

Strengthening pharmacovigilance systems through Africa-Europe collaboration: Insights from a regulatory roundtable discussion

Background Many African countries have established national pharmacovigilance (PV) centers under their medicines regulatory authorities, but multiple barriers still limit system performance. Comprehensive, well-enforced PV regulations are often lacking, and the reporting culture...