University of Oslo

A phosphoinositide and RAB switch controls early macropinocytosis

Macropinocytosis is a non-selective endocytic process by which cells take up large amounts of extracellular fluid into giant vesicles known as macropinosomes. This mechanism is used by immune cells to sample the surroundings for antigens and can be exploited by cancer cells for n...

Nicotinamide Riboside for Patients With Early-Stage Parkinson Disease

Importance Nicotinamide riboside, a nicotinamide adenine dinucleotide precursor, has been proposed as a potential disease-modifying therapy for Parkinson disease based on preclinical and early studies. Whether prolonged oral nicotinamide riboside improves clinical outcomes in Par...

Social processes in well-being (SoWell): A survey and ecological momentary assessment twin study

Aims : The Social Processes in Well-being (SoWell) study is an intensive longitudinal twin study designed to examine the relationships between mental health and social and environmental factors over time and to address the genetic contribution to these associations. Methods : App...

A constructional theory of sets, parts and relations

Abstract We develop a constructional approach to ontology, focusing on sets, parts and relations. On this conception of ontology, one starts with some constructors and an initial collection of objects. Then, new objects emerge by construction, that is, from the application of con...

Dislocation dynamics on deformable surfaces

Abstract We develop a fully coupled theoretical description of dislocation dynamics on deformable crystalline surfaces, using continuum modelling and the amplitude-phase-field crystal (APFC) framework extended to curved geometries. We derive a general kinematic expression for dis...

Signatures of photospheric convection throughout the solar atmosphere: the EVE Sun-as-a-star mHz continuum

Abstract Convectively driven motions in the solar photosphere can generate broadband Doppler variability across the chromosphere, transition region and corona. Here we investigate this variability using “Sun-as-a-Star” observations from the Extreme Ultraviolet Variability Experim...

Analysis of circulatory extracellular vesicle–associated cytokines as candidate disease-associated markers in ER-positive breast cancer

Abstract Introduction Cytokines are signaling molecules produced by various cell types, including immune cells, and play important roles in tumor development and progression. Extracellular vesicles (EVs) are small membrane-bound particles secreted by all cell types, including can...

AI-assisted discovery of an ABCA1/ABCG1 activator for restoring mitophagy and mitigating Alzheimer’s pathology

Abstract Defective mitophagy is a key pathological risk of Alzheimer’s disease (AD), yet available pharmacological agents capable of restoring mitophagy remain clinically limited, largely due to the lack of tools for drug screening and target identification. To address this, we i...

Normative clinical language data and task specific effects

Language production in clinical populations varies by both neurological condition and discourse task. This study analyzes connected speech from 1394 individuals with left or right hemisphere damage, Traumatic Brain Injury, Mild Cognitive Impairment, dementia, or no neurological d...

Combining TAG ‐ 72CAR with anti‐ MUC16CAR improves the potency of ovarian cancer treatment

Ovarian cancer (OC) is typically associated with poor prognosis and high mortality. Chimeric antigen receptor (CAR) T‐cell therapy offers a promising strategy, yet its application in solid tumours remains constrained by limited efficacy and on‐target/off‐tumour toxicities. We pre...

Political Advantage, Political Risk: The Nascent Stage of Statoil’s International Expansion, 1978–1999

This article analyses how the dynamics between the Norwegian national oil company Statoil and its government owner gradually changed during the 1980s and 1990s, as Statoil invested in politically risky business environments outside its domicile. Yet, despite this seemingly profit...

Policy-as-practice: exploring the ‘hidden sides’ of policy-making in sustainability transitions

While research on the politics of transitions has examined power dynamics, coalitions, and value contestations, the ‘hidden’ sides of operational governance, such as micro-political dynamics, strategies and tensions within decision-making spaces, remained largely underexplored. C...

Insensitivity to skin pain, tickling, and spicy food in a woman with a pathogenic NAA10 variant: a case report

Abstract Background The NAA10 gene on the X chromosome encodes NAA10, the catalytic subunit of the N-terminal acetyltransferase complex NatA, which co-translationally acetylates nearly half the human proteome. From the variety of NAA10 substrates, one would surmise that the pheno...

Caysichite-(Y) Ca4(Y,REE)4(Si8O20)(CO3)6·8H2O: Endmember Composition and Structure Established from New Occurrences Across Different Geologic Settings

Abstract The heavy rare earth element silicate-carbonate mineral caysichite-(Y) [Ca4(Y,REE)4(Si8O20)(CO3)6·8H2O] was discovered in the alkaline granite of the Golden Horn Batholith, near Washington Pass, Okanogan County, Washington, USA, as sub-millimeter euhedral orthorhombic pa...

Big data and psychiatry: advances, constraints and future directions.

Early work in psychiatry research, often involving single sites, small samples, and limited variables, has shifted to contemporary research involving multiple sites, large samples, and many variables. Such research raises important questions, including concerns about data quality...

Assessing and Addressing Frailty in Candidates for Lung Transplantation: An ISHLT Consensus Statement.

The ISHLT Consensus document for the selection of lung transplant candidates recommends frailty assessment as part of a comprehensive candidacy evaluation. Missing from this and other recent consensus documents were practical recommendations on which frailty measures to consider...

Ionospheric currents and auroral signatures during successive earthward bursty bulk flows and dipolarization: a 7 December 2023 case study

Earthward bursty bulk flows (BBFs) in the central plasma sheet are frequently accompanied by dipolarization fronts, and together they account for a large fraction of the energy and momentum transported from the magnetotail to the high-latitude ionosphere through field-aligned cur...

Urban–rural disparities in care deficit among functionally impaired older adults in China: prevalence gaps and shared determinants, 2013–2020

Global population aging highlights equitable elder care as a crucial challenge. China’s rapid aging amid a marked urban-rural divide offers a critical context to examine structural disparities in care deficits. This study aims to quantify urban-rural disparities in care-deficit p...

Automated echocardiographic measurements for longitudinal monitoring of ATTR cardiomyopathy: agreement and repeatability analysis

Detection of disease progression is key to personalize treatment strategies in transthyretin cardiomyopathy (ATTR-CM), particularly with emerging therapies. Echocardiography can detect subtle longitudinal changes but is limited by operator dependence. This study evaluates agreeme...

Medication use during pregnancy in Europe and North America: a systematic review

To describe the mean number of medications used as well as the prevalence of medication use throughout pregnancy in Europe and North America, with a focus on use by trimester, type of medication, and use of harmful medications. A systematic review was performed searching MEDLINE,...