University of North Carolina at Chapel Hill

Interoceptive Accuracy, Metacognition, and Facial Trustworthiness Perception Across the Adult Lifespan

Abstract Older adults often exhibit more positive impressions when forming trustworthiness impressions based on facial appearance. These judgements influence social decisions in later interpersonal interactions and are thought to put older adults at greater risk of victimization....

Toeplitz matrix formulation of polymer physics: From single chain statistics to liquid-crystalline order

We develop a Toeplitz matrix formulation of polymer statistics that provides a unified, analytically tractable description of flexible and semiflexible chains. Bond-vector correlations are encoded in a Toeplitz matrix, with a single parameter controlling the decay of orientationa...

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

OBJECTIVE: SIRT6 is a nuclear-localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL-800, decreases the severity of age-associated osteoarthrit...

Food for thought: a mixed methods analysis of nutrition decision making during bedside rounds in the neonatal intensive care unit

BACKGROUND: Variation in nutrition delivery contributes to poor growth in preterm infants in the neonatal intensive care unit (NICU); however, few studies have examined how clinicians develop nutrition plans. The aim of this research is to describe the nutrition decision-making p...

Modality and cultural tailoring in human–AI disaster communication: examining mechanisms and outcomes for Hispanic communities

Purpose This study examines how GenAI chatbots can support Hurricane preparedness among Hispanic/Latino communities by comparing combined audio-text delivery with text-only delivery and culturally tailored with generic content. It focuses on information overload and emotional att...

A Symposium on Jeff Spinner-Halev and Elizabeth Theiss-Morse’s Respect and Loathing in American Democracy: Polarization, Moralization, and the Undermining of Equality

Respecting citizens across political divisions is something many take for granted as important for democracy. Respect is central to democratic discussion and democratic equality. If we respect one another, we are more likely to listen to those with whom we disagree, to take the c...

GRIA2 Variant Associated With Paradoxical Response to Perampanel Expanding the Spectrum of GRIA2 ‐Related Epileptic Encephalopathy: Case Report and Literature Review

ABSTRACT Introduction GRIA2 encodes the GluA2 ionotropic α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor subunit. Pathogenic GRIA2 variants cause epilepsy, developmental delay, and neurobehavioral disorders. Characterizations of clinical features, including s...

Validation of Low-Frequency Oscillatory Activity as an Indicator of Post-Stroke Injury and Recovery

BackgroundThis study investigated the roles of delta (1-3 Hz) and beta (20-30 Hz) electroencephalography (EEG) oscillatory activity at rest in post-stroke recovery. Driven by previous work linking delta and beta activity with stroke-related injury and motor recovery, this study s...

THROUGH THE LOOKING GLASS: THE POTENTIAL OF RESEARCHER LIVED EXPERIENCE IN PSYCHIATRIC GENETICS

The importance of including lived experience perspectives in psychiatric research is being increasingly recognized. However, the potential contribution of researchers with lived experience is an important yet underdiscussed perspective. Typically, the groups of ‘researcher’ and ‘...

Gabapentin Use in Medicaid After Descheduling

This cross-sectional study investigates the association of descheduling of gabapentin with use among Medicaid enrollees in Michigan.

45. A “PERTURB-SEQ” STUDY OF SCHIZOPHRENIA

Background Schizophrenia affects approximately 1% of the population worldwide and is among the most heritable psychiatric disorders. Decades of genomic discovery have identified hundreds of risk loci via genome-wide association studies (GWAS), whole-exome sequencing (WES), copy n...

Exploring BMI Classification Changes and Disparities Upon Incarceration in U.S. Federal Prisons

Information on body mass index (BMI) fluctuations during multiyear incarceration is limited, with publications on BMI changes leading to reclassification even more sparse. This is particularly important because access to novel treatments, such as glucagon-like peptide-1 (GLP-1) t...

Consensus-Based Definitions for Vocal Biomarkers: The International VOCAL Initiative.

Introduction: Voice-based health technologies are growing rapidly, but they lack standardized terminology, which hinders interdisciplinary collaboration, research quality, and clinical translation. The objective of this work was to develop universally accepted definitions in the...

A framework and practical guide for conducting double-blind randomized clinical trials combining transcranial electrical stimulation and psychotherapy

Transcranial electrical stimulation (tES) is a non-invasive technique for modulating neural activity with minimal side effects, making it ideal for delivery concurrent with evidence-based psychotherapy. However, combining these modalities introduces unique methodological challeng...

Contribution of Adolescent Movement Behaviours to Socioeconomic Inequalities in Adult Cardiovascular Disease Risk: A Causal Decomposition in a Population-Based Cohort

Abstract Addressing unhealthy movement behaviours in adolescence could reduce socioeconomic inequalities in adult cardiovascular disease (CVD) risk. Among 6608 adolescents enrolled in the Add Health cohort (1994-1995) and followed into adulthood (2016-2018), movement behaviours (...

Indices of obesity, malnutrition and inflammation are strong predictors of mortality in adults with type 2 diabetes: the FIELD study

Abstract Aims/hypothesis Metabolic risk in type 2 diabetes is not fully captured by standard clinical measures. Use of NMR-based metabolomic indices may enhance risk prediction, but their role in individuals with type 2 diabetes is unresolved. Methods We analysed data from 9550 a...

Sexual health and healthy aging: the five ‘I’s conceptual framework

Sexual health remains important throughout life, including in older age. This special collection shows that older adults need respectful, inclusive, and culturally appropriate sexual health services. The five ’I’s framework – importance, individuality, inclusion, involvement, and...

Prevalence of laryngopharyngeal reflux symptoms in divers

Introduction: Laryngopharyngeal symptoms (LPS) refer to aerodigestive complaints that may result from the retrograde flow of gastric contents into the upper aerodigestive tract. These symptoms may be under-recognised in populations exposed to mechanical or environmental stressors...

Pharmacokinetics and Physiologically Based Pharmacokinetic Modeling of Mycobacteriophages: Insights into Pulmonary Distribution and Clearance

Abstract Bacteriophage therapy is being explored as an alternate therapeutic approach for treating drug-resistant bacteria, including mycobacteria. However, rational phage dosing remains limited by scarce pharmacokinetic (PK) data and an incomplete understanding of tissue distrib...

Melding Structured Care With Improvisation—Jazz in Medicine

This Viewpoint draws parallels from the improvisation within structure of jazz music and explains how to harmonize the use of structured pathways with the need to improvise in patient care.