University of North Carolina at Chapel Hill

Thermal Transport in Disordered Network Metamaterial

Disordered materials occur naturally and offer a broader design space than ordered or crystalline structures. We investigate transient thermal transport in two-dimensional network metamaterials constructed from Delaunay triangulations of underlying point patterns, with varying de...

Allelic gene conversion softens selective sweeps

The prominence of positive selection, in which beneficial mutations are favored by natural selection and rapidly increase in frequency, is a subject of intense debate. Positive selection can result in selective sweeps, in which the haplotype(s) bearing the adaptive allele sweep t...

Enteric pathogens in soil adjacent to public waste bins in Maputo, Mozambique offers potential for environmental surveillance

Abstract Wastewater surveillance has been widely adopted since the COVID-19 pandemic, but non-sewered or onsite sanitation is a common form of sanitation in cities of low- and middle-income countries. Environmental surveillance in these settings requires expanding analyses beyond...

Real-Time Symptom and Wearable Monitoring May Improve Prediction of Postoperative Recovery in Lumbar Spine Surgery Beyond Standard Measures

BACKGROUND AND OBJECTIVES: Accurately identifying candidates likely to benefit from surgery and addressing modifiable preoperative risk factors are central to optimizing outcomes. Current prediction tools often rely on static clinical data and patient-reported measures, which lac...

Morphogenesis of bacterial colonies in liquid crystalline environments

Natural bacterial habitats are often complex fluids with viscoelastic and anisotropic responses to stress; for example, they can take the form of liquid crystals (LCs), with elongated microscopic constituents that collectively align while still retaining the ability to flow. Howe...

Putting Globus Into Context: Prevalence, Characteristics, and Overlap With Other Disorders of Gut‐Brain Interaction

OBJECTIVE: Globus is characterized by the sensation of a lump in the throat without dysphagia or underlying structural abnormality or major motility disorder. Reported prevalences vary considerably across studies. Globus has been linked to both heartburn and affective disorders....

Redox‐Active SnMoS x Chalcogels for Multi‐Electron Reductive Separation of Chromate and Pertechnetate

ABSTRACT High‐valent oxyanions, such as chromate (Cr VI O 4 2− ) and pertechnetate ( 99 Tc VII O 4 − ), are highly soluble, weakly coordinating, and exceptionally stable, making their removal from water and nuclear waste extremely challenging. Here, we report a redox‐coupled meta...

MERTK inhibition cooperates with immunomodulatory cyclophosphamide to induce CXCL9⁺ monocyte-macrophage programming and durable antitumor immunity in triple negative breast cancer

ABSTRACT Triple-negative breast cancer (TNBC) has high rates of recurrence despite chemotherapy and immune checkpoint blockade (ICB). Tumor-associated macrophages (TAMs) can either suppress or support anti-tumor immunity, but the mechanisms governing these states and therapeutic...

MatUQ: a benchmark for uncertainty-aware out-of-distribution materials property prediction with graph neural networks

Abstract Reliable uncertainty quantification (UQ) for graph neural networks (GNNs) under out-of-distribution (OOD) shifts remains insufficiently characterized in materials discovery. Existing benchmarks based on random splits can overestimate model reliability by underrepresentin...

Therapeutic Reversalof PH-HFpEF via Lung SpheroidCell Exosomes

Abstract Pulmonary hypertension–associated heart failure with preserved ejection fraction (PH-HFpEF) is a prevalent and lethal cardiopulmonary syndrome without effective disease-modifying therapy. We investigated the therapeutic potential of lung spheroid cell–derived exosomes (L...

Hospital Capacity Pooling in Pandemics: Simulation‐Based Mortality Impacts and Diversification Mechanisms

Elevated healthcare strain during the COVID-19 pandemic increased patient mortality rates and prompted costly non-pharmaceutical interventions. This work examines how the size of a hospital's service population, which can be expanded by linking hospitals through patient transfer...

Electroreduction of Activated Esters Catalyzed bya Manganese Complex

Abstract Electrochemical hydrogenation (electrohydrogenation) using electrons and protons as H2 surrogates offers a sustainable alternative to conventional reduction methods. Herein, we report the manganese-catalyzed electroreduction of activated esters employing a derivative of...

Patient-centered approaches in psoriasis management: lessons from the past and future directions

INTRODUCTION: Psoriasis is a chronic immune-mediated disease with physical and psychosocial burden that is not fully captured by measures of skin lesion characteristics. Advances in therapies, including multiple biologic treatments, have improved disease control, but gaps remain...

Bevacizumab Reduces Epistaxis‐Related Operative Burden in Hereditary Hemorrhagic Telangiectasia

Key Points Bevacizumab reduced epistaxis‐related ablation frequency by 55.6% in HHT patients. Over half of HHT patients (57.7%) required no ablation intervention after bevacizumab initiation. Maintenance bevacizumab dosing remains highly variable, underscoring the need for standa...

Acceptability and Feasibility of a Primary Care Hypoglycemia Prevention Program: A Pilot Study

OBJECTIVE Hypoglycemia, a major cause of morbidity for people with diabetes, is underrecognized in primary care, leading to underuse of risk mitigation strategies. This study reports the development and acceptability/feasibility testing of the Hypoglycemia Prevention Program (HPP...

The hematology workforce in the United States: past, present, and strategies for the future

From 2017-2021, the American Society of Hematology (ASH) completed the largest study ever conducted of the hematology workforce in the United States (US). The study highlighted a deficit in the classical hematology (CH) workforce: despite very high CH clinical volumes encountered...

Integrating mental health support into care for placenta accreta spectrum: a qualitative analysis of patient perspectives

Abstract Background Patients with high-risk pregnancies due to placenta accreta spectrum (PAS) are at high risk of morbidity and mortality, which may increase risk for childbirth related mental health sequelae including postpartum post-traumatic stress disorder (PTSD) and trauma...

Commensal bacteria inhibit viral infections via a tryptophan metabolite

Clinical outcomes following viral exposures exhibit substantial interindividual variability. Although developing evidence suggests commensal bacteria modulate viral infections, the specific bacteria and mechanisms remain underexplored. Here, we define a pathway by which viral inf...

ICD ‐10‐ CM ‐Based Algorithms to Identify Bacteremia Incorporating Pathogen‐Specific Codes: A Validation Study

ABSTRACT Purpose Studying patients with bacteremia in real‐world data often requires using microbiologic data to confirm bacterial growth and species. When microbiologic data are unavailable, pathogen‐specific diagnostic codes may be used to classify the bacteremia type. We devel...

Stereoselectivity inLiquid Aerosols through Acid-MediatedEpoxide Ring-Opening Reactions

Abstract Stereoisomers in aqueous atmospheric aerosols are assumed to be present in equal concentrations, as aerosols are most commonly mixtures of simple inorganic salts with a range of organic species that lack obvious pathways to induce stereoselectivity. Further, since submic...