University of North Carolina at Chapel Hill

Infant hippocampal and amygdala volume in an observational follow-up from a randomized clinical trial for maternal prenatal depression

Abstract Prenatal maternal depression may have intergenerational effects on offspring brain development, with potential socioemotional consequences. This observational follow-up study examines brain development and subsequent negative emotionality among 109 infants born to mother...

Supporting Socialization Skills of Preschoolers with Developmental Delays in Inclusive Education: An Early-Career Teacher’s Implementation of Curriculum Modifications

This practitioner action research examined how an early-career preschool teacher implemented Building Blocks–informed curriculum modifications to support the socialisation-related IEP goals of two children with developmental delays in an inclusive public preschool in Taiwan. Clas...

Integrating ctDNA-Based ESR1 m Monitoring Into First-Line Care for ER+, HER2– Advanced Breast Cancer: A Consensus Workflow

Circulating tumor DNA (ctDNA) is an emerging tool in precision oncology that enables noninvasive tumor profiling, detection of minimal residual disease, and treatment monitoring. Furthermore, routine ctDNA analyses offer the potential to support more personalized and dynamic canc...

Sequential Exposure to Acute, Intermediate, and Late Synovial Fluid Fracture Hematoma after Ankle Fracture Promotes Cartilage Damage in Vitro Partially Attenuated by Anti Inflammatory Agents

Background Post-traumatic osteoarthritis (PTOA) following intra-articular fractures (IAFs) remains a common sequela after injury. Cartilage degeneration after injury is influenced by multiple factors, including elevated proinflammatory cytokines produced by synovial fluid fractur...

Evidence of vertical soil hydraulic heterogeneity regulating hydrothermal simulations in Qinghai–Tibetan Plateau wetlands

Abstract. Alpine wetlands on the Qinghai-Tibetan Plateau host vertically structured and highly contrasting pore systems that fundamentally shape land and atmosphere exchanges, yet their hydraulic expressions and process implications remain poorly quantified. This study provides t...

A randomized phase II study of fulvestrant with or without ganetespib in patients with endocrine resistant metastatic breast cancer

Abstract Background Patients with endocrine-resistant hormone receptor-positive (HR+), HER2-negative metastatic breast cancer (MBC) have limited effective treatment options. Heat shock protein 90 (HSP90) regulates estrogen receptor stability and function; its inhibition has been...

Cross-sectional Comparison of the PREVENT and Pooled Cohort Equations for 10-Year Atherosclerotic Cardiovascular Risk Estimates in a U.S. Cohort of Black and Latina Transgender Women with HIV

Background: Transgender women with HIV face higher rates of atherosclerotic cardiovascular disease (ASCVD) than the general population. However, ASCVD risk estimators use binary sex variables that may misclassify their risk. We examined the effects of sex variable inputs in the P...

Accurate and Robust Measurement of Single-Molecule Fluorescence Spectral Heterogeneity

Abstract Understanding single-molecule fluorescence spectral heterogeneity (smFLUSH) is vital for developing new probes for multidimensional super-resolution microscopy and decoding nanoscopic environments. However, traditional analysis methods distort the data and fail to distin...

Faculty Development Workshops to Mitigate Biased Language and Enhance Quality in Medical Student Narrative Assessments

Introduction Narrative assessments are increasingly important in medical education, especially following the transition of USMLE Step 1 to pass/fail. However, these assessments are often of variable quality and may contain subjective language, potentially impacting career opportu...

Testing peripheral and central therapies for provoked vestibulodynia: results from the UPDATe trial

Introduction Vestibulodynia (VBD) is a common chronic pelvic pain condition with heterogeneous clinical presentation, including subtypes distinguished by the presence (VBD-central; VBD-c) or absence (VBD-peripheral; VBD-p) of comorbid pain conditions. Despite frequent prescribing...

From Hesitancy to Healing: Mental Health Discussions in Hair Care Settings as Pathways to Self-Care Among Black First-Year College Students

The present study examined whether hesitancy to seek professional mental health services was associated with mental health discussion with hairstylists or barbers and whether these discussions were associated with various forms of self-care among Black first-year college students...

Feminist anthropologies in the contemporary world: A conversation on theory, praxis, and politics

Abstract This article brings together the voices of members of three major feminist anthropological associations to discuss the state of feminist anthropology as a distinct subfield of anthropology, as well as its state of affairs as an increasingly expanding, as well as increasi...

From Resection to Transplantation: Rethinking Training and Certification for the Modern HPB Surgeon

Hepatopancreatobiliary (HPB) surgery has evolved beyond the confines of traditional liver and pancreatic resection. Contemporary practice increasingly encompasses advanced vascular reconstruction, extended hepatectomy in compromised livers, transplantation for malignancy, and com...

Superficial acral fibromyxoma: A masquerade of onychomatricoma

Superficial acral fibromyxoma (SAF) is a benign nodular tumour with distinct histopathologic findings that distinguish it from other soft-tissue tumours, though clinical findings can be deceptively similar to other pathologies. With prompt recognition, including histologic confir...

The relationship between lean mass and protein intake in females of African and East Asian descent

Low lean mass (LM) is associated with increased cardiometabolic disease risk and increased injury risk. Protein (PRO) intake is an important strategy to build and maintain LM. There is limited data quantifying PRO intake and evaluating the association between PRO intake and LM in...

Experiences of Mothers Following the Medicaid Postpartum Extension

Importance The American Rescue Plan Act of 2021 extended postpartum coverage for women eligible for Medicaid for Pregnant Women from 60 days to 12 months. Understanding how mothers experienced the postpartum extension is vital in evaluating this policy change and informing policy...

The circulating lipidome in severe obesity

Severe obesity (SevO; BMI ≥ 40 kg/m 2 ) is rising globally yet remains understudied mechanistically. To characterize lipidomic alterations at the species level, we analyzed Border Health Research Cohort participants with fasting plasma lipidomics and genetic data, comparing SevO...

Meaningful goal setting for communication disorders in acute hospital care: expanding the FOURC model

Background The FOURC model was developed to guide collaborative goal setting between speech-language pathologists and their adult clients (Haley et al. 2019). It was first implemented in outpatient clinics for clients recovering with poststroke aphasia. Here, we present an extens...

A scoping review of student peer evaluations in health professions education

Peer evaluation is widely used within collaborative learning environments in health professions education to develop teamwork, communication, and feedback skills. However, the terms peer evaluation, peer assessment, and peer feedback are often used interchangeably, and implementa...

Expansion of Freshwater Harmful Cyanobacteria in Brackish Waters: Salt Stress Responses, Toxigenic Dynamics, and Ecological Risks along the Freshwater-to-Marine Continuum

Abstract In recent years, freshwater harmful cyanobacterial blooms (CyanoHABs) and their associated cyanotoxins have been increasingly detected in estuaries and coastal lagoons, indicating that some freshwater taxa can survive in low-to-moderate salinity and may maintain their to...