University of Miami

Short-term oxycodone exposure produces delayed and persistent gut microbiome disruption in mice

Abstract The gut microbiome is a critical part of host homeostasis, yet its resilience following opioid exposure remains poorly understood. While opioid-induced short-term dysbiosis is well documented, the long-term recovery dynamics following oxycodone remain unclear. This study...

Coherent eddies redistribute microplastics across the water column

Abstract The ocean interior is emerging as a hidden reservoir of microplastics, yet the mechanisms governing their accumulation below the surface remain poorly understood. Despite growing interest in microplastic distribution throughout the ocean, in-situ observations within smal...

Sex and Self-reported Race: Factors Associated with Anal Mucosal Melanoma and Anal Mucosal Pigmentation?

Anal canal melanoma (ACM) is a rare, aggressive malignancy with an ominous prognosis. However, its associated factors are largely unknown. Therefore, we investigated potential independent associations of sex and self-reported race with ACM and physiological anal canal pigmentatio...

Proliferation of enterococci in sargassum can contribute towards sand and water quality impairment

Abstract The fecal indicator bacteria (FIB), enterococci, are used to evaluate the safety of beach waters and beach sands. The increasing quantities of the holopelagic macroalgae Sargassum fluitans and Sargassum natans (referring to herein as “sargassum”) along beaches that face...

Global Efforts to Reduce Paediatric Cancer Care Disparities in Radiotherapy: A Decade Change

ABSTRACT Background We present an update on the status, needs and challenges faced by paediatric imaging and radiotherapy (RT) programmes globally after a previous survey conducted by the International Atomic Energy Agency (IAEA) 10 years prior. Methods We developed and distribut...

Improving HIV Prevention Among Hispanic Women Through a Community-Researcher Partnership: Florida, 2020-2023.

The need for culturally grounded, evidence-based HIV prevention interventions targeting preexposure prophylaxis (PrEP) and HIV testing for Hispanic women prompted us to adapt the evidence-based SEPA (Salud/Health, Educación/Education, Prevención/Prevention, Autocuidado/Self-Care)...

A Framework for Decisions for Parents Along the Early Hearing Detection and Intervention Journey

Parents of children who are deaf or hard of hearing (D/HH) must make many complex decisions during their child’s infancy and early childhood. Identifying key decision points will help guide the development of shared decision-making tools. We began by identifying 4 domains to clas...

End of an Era, or Just Another Inflection Point in the History of Newborn Screening in the United States?

We have reached another inflection point—perhaps the end of an era—in state newborn screening programs. Frequently touted as one of the great achievements in public health, newborn screening in the United States is remarkable in part because of the role of state government in rou...

Weak, shallow, dry convection over Angola increases offshore stratocumulus cloud droplet number concentrations

Boundary-layer cloud interactions involving shortwave-absorbing aerosols remain one of the least understood aerosol influences on climate. Here, we find the highest stratocumulus cloud droplet number concentrations over the southeast Atlantic occur when agricultural fires coincid...

AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other embryonal tumors

WHO CNS5 mandates integrated histo-molecular classification of medulloblastomas (MBs) and other CNS embryonal tumors. However, advanced molecular diagnostics remain inaccessible in many low- and lower-middle-income countries (LICs/LMICs), limiting implementation of molecularly in...

Clinical Relevance of Calcifications in Osteosarcoma Lung Metastases: Correlations Among Radiological Patterns, Histological Subtypes, and Chemotherapy Responses

Background/Objectives: Osteosarcoma is a rare malignancy and the most common primary malignant bone tumor. Metastases commonly affect the lungs and are associated with reduced life expectancy. Calcifications can be present within a metastatic nodule at baseline or can appear duri...

Cyclic Sieving of Multisets with Bounded Multiplicity and the Frobenius Coin Problem

The two subjects in the title are related via the specialization of symmetric polynomials at roots of unity. Let $f(z_1,\ldots,z_n)\in\mathbb Z[z_1,\ldots,z_n]$ be a symmetric polynomial with integer coefficients and let $\omega$ be a primitive $d$th root of unity. If $d|n$ or $d...

Beyond Multiple Choice: The Association between Diagnostic Reasoning Exams and Medical Student Learning Strategies

Abstract Introduction Assessment format shapes how medical students study. While multiple-choice questions (MCQ) are widely used, they may incentivize pattern recognition and memorization. We developed and implemented a novel open-ended assessment format, the Diagnostic Reasoning...

General OOD detection via model-aware and subspace-aware variable priority

Abstract Out-of-distribution (OOD) detection flags test inputs that depart from the data used to train a model. For structured tabular problems with regression or survival outcomes, existing methods remain limited because many OOD detectors are designed for classification or unst...

Atypical PI3Ks coordinate chemotaxis, signaling dynamics, and multicellular development in Dictyostelium

Phosphoinositide 3-kinase (PI3K) signaling regulates protrusion, polarity, membrane uptake, and multicellular development in Dictyostelium discoideum, but these functions have been interpreted largely through canonical Class I PI3Ks and PI(3,4,5)P₃ production. This framework does...

A Decay Rate for Steady Guaranteed In‐Control Performance in Statistical Process Control Models With Cautious Parameter Learning

ABSTRACT Control charts with parameter estimates from small Phase I samples are at risk of providing inaccurate signals due to poor model fit. In turn, Guaranteed In‐Control Performance (GICP) approaches were introduced to account for the resulting variability in the conditional...

The cymothoid isopod Anilocra chromis is negatively associated with multiple metrics of host condition in the Caribbean damselfish Chromis multilineata

Abstract Parasitism is widespread among fishes in nature and can have significant impacts on individuals, populations, and communities. The family Cymothoidae includes over 380 species of parasitic isopods that infect a wide variety of host fishes, mostly in tropical and subtropi...

Associations between physical activity levels and socioeconomic and occupational factors among a large workforce population: insights from an employee health cohort study

Abstract Background Physical inactivity is a growing concern among working populations, with implications for health and productivity. Unlike most previous studies, this research draws on large-scale cohort data from Iranian employees to examine the associations with socioeconomi...

Impact of Response to Hypomethylating Agent‐Based Therapy on Survival Outcomes in the Context of Baseline Clinical‐Molecular Risk and Transplant Status in Patients With Higher‐Risk Myelodysplastic Syndromes/Neoplasms: An analysis From the International Consortium for MDS (icMDS)

Baseline IPSS-M risk, response to hypomethylating agent (HMA) therapy, and receipt of allogeneic stem cell transplant (allo-HCT) have all been individually shown to impact overall survival (OS) in patients with myelodysplastic syndromes (MDS). However, the prognostic impact of re...

A cumulative cold dosimetry model for cryoablation: from geometry to dose-time planning

Abstract Purpose To propose a cumulative cold dose (CCD) model integrating spatial, temporal, and biological dosimetry for cryoablation protocol optimization. Methods Systematic searches identified studies reporting freeze duration effects, cell-type-specific lethal thresholds, l...