University of Miami

The silent pandemic: the overlooked toll of stroke compared to COVID-19

The COVID-19 pandemic will be remembered as one of the defining health crises of the modern era. The World Health Organization reported approximately 7 million deaths attributed to COVID-19 globall...

Functional seizures: care experiences of U.S. Veterans and their care partners

Functional seizures (FS) present substantial diagnostic and treatment challenges, particularly for Veterans with multiple medical and psychiatric comorbidities including post traumatic stress disorder, mood disorders and traumatic brain injury. To more effectively care for Vetera...

Development of NanoBRET Cellular Target Engagement Assays in Primary Neurons for Activating Mutants of p21-Activated Kinase 1

Abstract The p21-activated kinases (PAKs) are a group of serine-threonine kinases central to multiple signaling pathways that govern cell survival and proliferation. Aberrant activity of PAK1, the most well characterized member of the PAK family, drives progression of several mal...

Physical and lifestyle predictors of vascular function in postmenopausal East Asian women: the women’s vascular health project

The cardiovascular disease (CVD) burden is especially pronounced in women after menopause accounting for more deaths worldwide than any other disease. The current research examined physical and lifestyle contributors to vascular health in postmenopausal East Asian women. Approxim...

Detailed Analysis of Intraretinal Layers and Their Correlation to Brain Structures in Normal Healthy Aging

Purpose: The purpose of this study was to investigate the relationships between intraretinal layer volumes and visual cortical thickness in healthy individuals and determine the influence of age on these associations. Methods: Fifty-three subjects were recruited. One eye per subj...

Association between plain-water consumption and suicide attempts among U.S. adolescents: Evidence from the 2017–2021 Youth Risk Behavior Survey

Background Adolescent suicide attempts remain difficult to predict, in part because research has concentrated on a narrow set of risk factors. We examined whether self-reported plain-water consumption is associated with past-year suicide attempt among U.S. adolescents, whether th...

Validation of pure and total movement dispersion variables as measures of the distribution of daily activity using accelerometers: a secondary analysis of a prospective cohort

Abstract Aim Physical activity (PA) positively impacts health, but the optimal way to achieve PA remains unclear. Pure and total movement dispersion are novel metrics that quantify the spread of movement across the day, with (total) or without (pure) intensity. The purpose of thi...

Genetic testing to distinguish X-linked protoporphyria from erythropoietic protoporphyria informed iron replacement therapy leading to reversal of severe protoporphyric hepatopathy

Erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP) are cutaneous porphyrias characterized by excess protoporphyrin IX (PPIX), leading to photosensitivity and, in a minority of patients, progressive hepatobiliary injury. Although XLP and EPP have similar clinica...

Localization and anticipation of seizure onset and propagation using network architecture of pathological high‐frequency oscillations

Abstract Objective In focal epilepsies, seizures originate from a presumed seizure onset zone (SOZ) and propagate through a network of dynamically interconnected brain regions. Accurate identification of the SOZ and propagation pathways is critical for surgical planning in patien...

Opening Hours and Consumer Behavior: Evidence From GPS Data and Deregulation

ABSTRACT In 2019, North Dakota repealed its Sunday closing law, which had required most non‐grocery stores to close between midnight and noon. Using this policy change and consumer GPS data, we study the impact of opening hours on shopping behavior and welfare. We compare visits...

Strengthening Parenting Programs Through Implementation Support: An Evaluation of Provider Engagement and Outcomes

Abstract Despite the widespread availability of evidence-based parenting programs, population-level improvements in child mental health remain limited, partly due to persistent challenges recruiting, engaging, and retaining families in services. Intermediary organizations have in...

Projecting Impacts of Marine Heatwaves and Their Effects on Long‐Term Changes in Marine Ecosystems Over the 21st Century

ABSTRACT Marine heatwaves (MHWs) are increasing in frequency, duration and intensity under climate change. Although current MHWs trigger broad ecological impacts, such as coral bleaching, mass mortality of seagrass meadows, and declines in important fish stocks, the cascading eff...

Estimating Infiltration and Inflow in Sanitary Sewers Using Flowmeter Data

Abstract This paper presents and demonstrates a method for extracting groundwater infiltration during dry periods and rainfall-driven infiltration and inflow during wet periods from sanitary sewer flowmeter data and related hydrologic measurements. The method is novel because it...

Listening as diversity management: Understanding the role of internal communication in fostering LGBTQ+ inclusion in a polarized context

Amid an increasingly polarized sociopolitical environment and the rollback of organizational diversity, equity, and inclusion (DE&I) initiatives, the pursuit of LGBTQ+ workplace diversity in the United States faces growing resistance and renewed vulnerability. While requisite var...

Augmenting patient safety surveillance in radiation oncology with large language model-based root cause analysis: A proof-of-concept study

We investigated the potential utility of large language models (LLMs) in supporting patient safety efforts. Specifically, we evaluated the reasoning capabilities of LLMs in performing root cause analysis (RCA) of radiation oncology incidents using narrative reports from the Radia...

Beyond Psoriasis Skin Clearance: Effects of Bimekizumab and Tildrakizumab on Systemic Inflammation and Immune-Nutrition Status

Background/Objectives: Psoriasis is a chronic immune-mediated inflammatory disease associated with a high systemic burden. Inhibition of the IL-23/IL-17 axis is the cornerstone of therapy, although the evaluation of immune-nutritional status in the assessment of psoriatic disease...

Positive selection screen identifies natural product β-catenin inactivators

Many genetically validated targets in cancer, including the transcription factor β-catenin (β-cat), have historically been viewed as undruggable. Cell-based phenotypic screening of chemical compounds can reveal unanticipated biological and pharmacological principles. Natural prod...

Mechanical Loading Reshapes Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicle microRNA Cargo Toward Predicted Immunomodulatory and EV Cargo-Trafficking Pathways: An In Vitro Mechanobiology Study

Mesenchymal stem/stromal cell-derived extracellular vesicles (MSC-EVs) are emerging as cell-free therapeutic candidates for osteoarthritis, but most approaches treat the secretome as a passively collected product rather than a tunable biologic. Because joint loading regulates car...

Celebrity Endorsement in the AI Era: How Synthetic Endorsements Featuring Living and Deceased Celebrities Shape Brand Opportunism Across Campaign Purposes

Generative AI is reshaping how living and deceased celebrities can be represented and reused in media and marketplace communication. Yet little is known about how consumers respond to AI-generated celebrity representations. Drawing on attribution theory and social contract theory...

Comparative effectiveness of GLP-1 receptor agonists, SGLT2 inhibitors, DPP-4 inhibitors, and sulfonylureas on weight change among people with HIV: a real-world longitudinal cohort study

Obesity is common among people with HIV (PWH), yet evidence on weight loss with newer antidiabetic medications in this population is limited. We compared bodyweight change associated with glucagon-like peptide-1 receptor agonists (GLP-1RA), sodium–glucose cotransporter-2 (SGLT2)...