University of Miami

Celebrity Endorsement in the AI Era: How Synthetic Endorsements Featuring Living and Deceased Celebrities Shape Brand Opportunism Across Campaign Purposes

Generative AI is reshaping how living and deceased celebrities can be represented and reused in media and marketplace communication. Yet little is known about how consumers respond to AI-generated celebrity representations. Drawing on attribution theory and social contract theory...

Comparative effectiveness of GLP-1 receptor agonists, SGLT2 inhibitors, DPP-4 inhibitors, and sulfonylureas on weight change among people with HIV: a real-world longitudinal cohort study

Obesity is common among people with HIV (PWH), yet evidence on weight loss with newer antidiabetic medications in this population is limited. We compared bodyweight change associated with glucagon-like peptide-1 receptor agonists (GLP-1RA), sodium–glucose cotransporter-2 (SGLT2)...

Simplified LYMPHA for Prevention of Breast Cancer-Related Lymphedema After Axillary Dissection: Initial Feasibility Experience from South Asia

Objective: Breast cancer-related lymphedema is an important survivorship concern after axillary lymph node dissection. Conventional LYMPHA and immediate lymphatic reconstruction can reduce this risk, but adoption in low- and middle-income settings is limited by the need for micro...

A design approach for bitopic kinase inhibitors

Abstract Traditional kinase inhibitors face a trade-off between potency and selectivity because their affinity depends on limited molecular interactions in a single highly conserved binding site. Bitopic inhibitors overcome this limitation by engaging multiple sites on the same t...

On an n-ary generalization of the Lie representation and tree Specht modules

We continue our study, initiated in our prior work with Richard Stanley, of the representation of the symmetric group on the multilinear component of an n -ary generalization of the free Lie algebra known as the free Filippov n -algebra with k brackets. Our ultimate aim is to det...

mGem: The two-decade evolution of in vivo coral microbiome manipulations

ABSTRACT Over the past two decades, microbiome manipulations have emerged as a strategy to bolster coral fitness. Here, we provide a timeline of two decades of research on in vivo coral microbiome manipulation studies aimed at improving coral health. A summary of coral hosts, pro...

An international position statement on practical approaches for inpatient continuous glucose monitoring, insulin pumps and automated insulin delivery systems in adults

There is an urgent and unmet need for a practical clinical guideline addressing the use of continuous glucose monitoring (CGM), insulin pumps and automated insulin delivery (AID) systems in hospital settings. The goal with this position statement is to facilitate effective and sa...

An International Position Statement on Practical Approaches for Inpatient Continuous Glucose Monitoring, Insulin Pumps, and Automated Insulin Delivery Systems in Adults

There is an urgent and unmet need for a practical clinical guideline addressing the use of continuous glucose monitoring (CGM), insulin pumps, and automated insulin delivery (AID) systems in hospital settings. The goal with this position statement is to facilitate effective and s...

Patterns of head and neck pain and obstructive sleep apnea in women with macromastia: A cross‐sectional analysis

Abstract Objectives/Background Symptomatic macromastia, or breast hypertrophy, is associated with musculoskeletal and neurological symptoms, including headache and neck pain. Though insurers list headache as an indication for breast reduction surgery, its relationship to specific...

“Perinatal mental health in rural contexts: risk factors, barriers, and pathways to support”

Perinatal mood and anxiety disorders (PMADs) are the most common complication of pregnancy, with rural populations facing heightened risk. Semi-structured qualitative interviews conducted with 33 participants in Montana revealed that risk factors for PMADs are multifaceted, and t...

Strategies for the Care of Mothers With Substance Use Disorder

Substance use disorder and opioid use disorder in pregnancy have serious maternal and neonatal sequelae, including neonatal abstinence syndrome, preterm labor, and intrauterine growth restriction. Despite this, there are limited resources and guidelines to help clinicians support...

BUB1B Mitotic Kinase Dependency Reveals CENP-E Inhibition as a Tractable Approach for Castration and Enzalutamide Resistant Prostate Cancer

Abstract Castration-resistant prostate cancer (CRPC) progression despite treatment with potent androgen receptor (AR) antagonists such as enzalutamide is a major clinical challenge. The mitotic kinase BUB1B is a central member of an oncogenic seven-gene network that drives CRPC....

Patient- and care-related factors associated with central line-associated bloodstream infection in adult intensive care units: a retrospective matched case-control study at a tertiary referral center

Central line-associated bloodstream infection (CLABSI) is an important preventable healthcare-associated infection in intensive care units (ICUs). This study evaluated patient- and care-related factors associated with CLABSI and described the causative microorganisms in adult ICU...

Cognitive Walkthrough Versus Usability Testing: Evaluating a GI Symptom-Tracking Application for Caregivers

This research compares two usability evaluation methods, Cognitive Walkthrough (CW) and Usability Testing (UT), in identifying design issues in a gastrointestinal symptom-tracking application for caregivers of people with neurodevelopmental disorders. Digital health tools increas...

A novel framework to modelling regulation of prey populations by a generalist predator

Abstract Background In ecological communities, a predator often feeds on several food sources. Such a predator is known as a generalist, and its feeding is traditionally modelled by a functional response. However, the conventional concept of the functional response is not applica...

Influence of Variant of Uncertain Significance (VUS) Genetic Testing Results on Mastectomy Choice in Lumpectomy-Eligible Patients

Abstract Purpose Our objective was to evaluate whether having a germline variant of uncertain significance (VUS) influenced the decision to undergo bilateral mastectomy (BLMast) among lumpectomy-eligible patients with unilateral breast cancer. Methods This retrospective cohort st...

Sex Disparity in Enrolment to Clinical Trials for Onchocerciasis and Trachoma

To determine whether female enrolment in randomized interventional clinical trials for onchocerciasis and trachoma reflects the real-world sex distribution of disease burden, and to evaluate sex-based differences across trial characteristics. We performed a cross-sectional analys...

3D Bioprinting in Anterior Segment Ocular Tissue Engineering: Advances, Challenges, and Translational Pathways—A Systematic Review

Bioprinting has been proposed for nearly every structure of the anterior eye, but the effort is unevenly spent. We systematically reviewed 71 experimental studies of bioprinting across the anterior segment: cornea, conjunctiva, sclera, lens, lacrimal gland and eyelid. Most work t...

The chromosomal genome sequence of the boulder star coral, Orbicella franksi (Gregory, 1895) (Scleractinia: Merulinidae)

We present a genome assembly from a specimen of Orbicella franksi (boulder star coral; Cnidaria; Anthozoa; Scleractinia; Merulinidae). The genome sequence has a total length of 496.97 megabases. Most of the assembly (95.24%) is scaffolded into 15 chromosomal pseudomolecules. The...

Timing and safety of prone positioning following median sternotomy in infants with single-ventricle physiology

Abstract Background: Prone positioning is an essential component of early rehabilitation and motor development in infants following cardiac surgery involving median sternotomy; however, restrictions remain variable due to concerns regarding sternal healing and safety. Due to a la...