University of Miami

Cutaneous phaeohyphomycosis with the recently described fungus Gloniopsis leucaenae: first case report

Abstract Background Fungi of genus Gloniopsis are plant pathogens within class Dothideomycetes, rarely described to cause human infection. Species Gloniopsis leucaenae ( G. leucaenae ) was first isolated in 2019 and previously reported only in plant matter in Thailand. Case prese...

Impact of Optical Coherence Tomography Angiography Scan Protocols on Quantitative Microvascular Biomarkers in Diabetic Retinopathy

Purpose: The purpose of this study was to evaluate the influence of optical coherence tomography angiography (OCTA) scan protocols on quantitative measurements of diabetic retinopathy (DR) biomarkers and their diagnostic performance for DR staging. Methods: In this cross-sectiona...

Productivity–efficiency-driven physician scheduling in emergency telemedicine

Emergency telemedicine networks require timely, reliable, and coordinated specialist coverage across geographically distributed hospitals. Scheduling physicians in such settings is challenging due to heterogeneous productivity, facility-dependent inefficiency, and nonuniform cred...

Aspergillus Endophthalmitis: Clinical Features, Treatment Modalities, and Visual Outcomes

Purpose: The purpose of this study was to evaluate clinical features, treatment modalities, and visual outcomes of Aspergillus endophthalmitis in a tertiary referral center. Methods: This was a retrospective consecutive case series of patients with Aspergillus endophthalmitis tre...

The Emergence of the Service Techonomy: POPP at the Frontlines and the Rise of AI-Mediated Service Influence

Advances in artificial intelligence (AI), data infrastructures, and platform technologies are reshaping services and organizational frontlines. We conceptualize this shift as the emergence of the “service techonomy,” in which omni-personalization manifests via Prescribed, Omnipre...

Peptide-Directed Nanomaterials to Elucidate Compositional Effects in Bimetallic Nanoparticle Catalysts

Abstract Multimetallic nanoparticle catalysts present exciting opportunities to achieve sustainable chemical transformations based on their unique structure that can lead to enhanced reactivity, especially when a blend of functional metal atoms is incorporated. The fundamental sc...

Real-World Versus Centers for Medicare and Medicaid Services Estimates of Pediatric Retinal Detachment Repair Times

Purpose: To compare real-world pediatric retinal detachment (RD) repair times with the Centers for Medicare and Medicaid Services (CMS) estimates for complex RD surgeries. Methods: A cross-sectional survey was performed of complex pediatric RD perioperative times from pediatric r...

Clinical Outcome Differences in Asia Versus Non-Asia Intracerebral Hemorrhage: IPD Analysis From BP-Lowering Clinical Trials

BACKGROUND: Evidence of regional differences in clinical outcomes after intracerebral hemorrhage (ICH) is still scarce. We quantified differential outcomes and response to early intensive blood pressure lowering treatment by region in the Blood pressure in Acute Stroke Collaborat...

Replace, Reprogram, and Relay: A Framework for Glial Cell and Extracellular Vesicle Therapies in CNS Repair

Glial cells shape inflammatory resolution, metabolic support, debris clearance, axonal preservation, and myelin repair after CNS injury and neurodegeneration. These functions have motivated two related but non-equivalent therapeutic strategies, either the transplantation and repl...

Kynurenine Pathway Activation is Associated with Poor Sleep Efficiency in Men With HIV

Background: Sleep disturbances are common in people with HIV, yet the underlying biological mechanisms remain poorly understood. Chronic immune activation in HIV can induce the tryptophan-kynurenine (TK) pathway, which both reduces melatonin synthesis and increases production of...

Mistaken actions: Davidson’s enduring dilemma

Abstract This essay is about a variety of action errors I call “Mistaken Actions” and a puzzle they pose for Causal Theories of Action. I begin with Davidson’s version of the Causal Theory and pose the puzzle as a dilemma: if his theory explains what makes a mistaken action mista...

Biological possibility: a mechanistic account

Abstract Current projects in synthetic biology, universal biology, and the origin-of-life study have posed a pressing issue regarding the nature of biological possibility. This essay proposes a novel account of biological possibility, which highlights the role of mechanism: X is...

Preliminary evidence of long‐term safety and effectiveness of anti‐ CGRP drugs for migraine prevention in people with comorbid epilepsy: A 52‐week follow‐up retrospective study

Abstract Migraine and epilepsy frequently coexist, but evidence on the safety of calcitonin gene‐related peptide (CGRP)‐targeting therapies in people with epilepsy is lacking. We evaluated long‐term migraine and epilepsy outcomes in a real‐world multicenter retrospective cohort o...

Observational Validation of Boundary‐Layer Cloud Regimes in Arctic Cold Air Outbreaks

Abstract Arctic cold air outbreaks (CAOs) produce low‐level cloud patterns influencing the surface radiative balance. The stability parameter (boundary‐layer height over Monin‐Obukhov length) is theorized to distinguish shear‐driven roll convection from buoyancy‐driven cellular c...

Validation of the International Working Group 2023 response criteria for higher risk myelodysplastic syndromes/neoplasms using the International Consortium for Myelodysplastic Syndromes VALIDATE database and a randomized phase III trial

Response assessment criteria in patients with higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) have been updated in the 2023 International Working Group (IWG) criteria. However, validation of these criteria has been limited to date. We analyzed overall survival (OS) by be...

Discovery and Optimization of a Novel Brain-Penetrant Colchicine-Binding Site Ligand for Treatment of Glioma

Abstract The limited number of approved drugs for treatment of brain cancers is very apparent. Temozolomide and Vorasidenib continue to be the only approved brain-permeable, orally available drugs. A novel class of highly brain-penetrant tubulin-binding ligands was discovered thr...

Dermal Fillers in Skin of Color: Safety Considerations, Cultural Perspectives, and Patient-Centered Approaches

BACKGROUND Patients with skin of color make up a growing share of aesthetic dermatology practice, yet evidence guiding filler treatment in this population remains limited. OBJECTIVE To review the evidence on dermal filler treatment in patients with skin of color, emphasizing safe...

Veno-Venous ECMO after Penetrating Trauma: A Viable Option With Individualized Anticoagulation

Background The incidence, clinical characteristics, complications, and outcomes for extracorporeal membrane oxygenation (ECMO) in penetrating trauma cases are mostly unknown. The purpose of this study was to evaluate the concept that ECMO could be a safe and effective therapy aft...

Round versus tape sutures with interference fit anchors perform similarly in cadaveric glenoid and greater tuberosity biomechanical testing

Abstract Purpose To determine whether suture shape (flat-tape vs. round-wire) influences biomechanical performance at the suture-anchor–bone interface in interference-fit anchors used for rotator cuff and glenoid labrum repair. Methods Four matched pairs of human cadaveric should...

Multivariate analysis identifies distinct latent components and highlights the contribution of motor cortex neurochemistry to clinical variance in amyotrophic lateral sclerosis

Abstract Amyotrophic lateral sclerosis (ALS) is marked by substantial clinical heterogeneity across motor and extramotor domains, yet how different neuroimaging modalities jointly relate to this heterogeneity remains poorly understood. Prior ALS neuroimaging studies have largely...