University of Helsinki

Problem-driven design methods for organizing collaborative learning: learning circles and change laboratories

Purpose This study aims to examine how two Nordic co-design methods, namely, learning circles (LC) and change laboratory (CL), support collaborative learning and system-level redesign in educational settings. The authors identify learning and facilitation principles that guide th...

To disappear or to hold on – the fate of Europe's mountain flora in a warming world

Europe's largest mountain ranges are hotspots of climate change with potentially profound consequences for its rich and unique flora. Recent evidence is pointing towards strong compositional changes in mountain plant assemblages and the loss of cold‐adapted species. Yet, other st...

Alcohol and other drug policies for health care workplaces: evaluation of the content, quality and implementability

Purpose Research on alcohol and other drug policies (AOD policies) at workplaces has been conducted mainly in the manufacturing industry and among general working population. There is a lack of research from health care workplaces. This study describes the content and evaluates t...

The Python simulations of chemistry framework: 10 years of an open-source quantum chemistry project

Over the past decade, the Python-based Simulations of Chemistry Framework (PySCF) has developed into a widely used open-source platform for electronic-structure theory and quantum chemical method development. This article reviews the major advances since the previous overview in...

Phytochemical-capped silver nanoparticles as functional antiviral nanomaterials: Computational and experimental analysis of nano–bio interactions with SARS-CoV-2 targets

The emergence of SARS-CoV-2 variants highlights the need for antiviral strategies integrating molecular inhibitors and nanostructured materials. This study employed a computational and network pharmacology approach to investigate clinically approved SARS-CoV-2 protease inhibitors...

Management practices and human–horse relationships are associated with horse personality traits

Abstract The human–horse relationship has evolved through centuries of domestication, shaping how horses are managed and interact with people. Horses show interindividual behavioural differences that constitute personality, with implications for welfare, management and human–hors...

Craniofacial growth in Mulibrey nanism and impact of growth hormone treatment

Abstract Background Mulibrey nanism (MUL) impacts cellular metabolism and leads to severe prenatal onset growth restriction, distinctive craniofacial features, heart disease, hypogonadism, and predisposition to tumors. Growth hormone therapy is commonly used in treatment of patie...

Multi-omic profiling reveals antibody-drug conjugate targetability in ovarian cancer

Abstract Antibody-drug conjugates (ADCs) require high and homogeneous target expression for optimal efficacy, yet the spatial, temporal, and cellular heterogeneity of clinically approved ADC targets in high-grade serous ovarian cancer (HGSC) remains incompletely defined. We analy...

Cluster-based identification of movement patterns in bilateral and unilateral drop jump tasks: insights into the performance–injury conflict

Stiff landing mechanics has been associated with increased anterior cruciate ligament (ACL) injury risk, yet it may optimise jump performance, creating a theoretical performance-injury conflict. This study examined movement patterns, their consistency, and performance during two-...

Plasma proteomic profiling of septic shock and acute pancreatitis identifies shared signatures and disease-specific pathways

Abstract Septic shock represents the most severe form of infection-driven systemic inflammation, whereas acute pancreatitis induces a sterile inflammatory response. Although clinically similar, their molecular profiles may reveal distinct mechanisms underlying infectious and non-...

Efficient pulsed lights for herbaceous and woody plants with different light demands

Effect of many different pulsed lights (PLs) on photosynthetic rate was measured in several temperate herbaceous and woody species. Pulsed lights with light/dark cycle periods (CPs) ranging from 100 to 0.004 ms and duty (light) phase ratios (DRs) between 88 and 43% were used. Eac...

Morphology-Based Surgery for Chronic Pancreatitis Across Europe: Toward the Next Generation of Unified Guidelines

OBJECTIVE: To evaluate the use and impact of current surgical guidelines for chronic pancreatitis (CP) across Europe. SUMMARY BACKGROUND DATA: Current guidelines recommend morphology-based surgery for CP, but international studies evaluating their use and impact are lacking. METH...

A global framework to estimate urban spatial cycling patterns based on crowdsourced data

Cycling is a cornerstone of a sustainable mobility transition in cities. Cycling research depends on the data available, but it has been difficult to produce or access these data in comparable ways. Sports tracking platforms like Strava have been transformative in mass-tracking c...

Screening ‘Gum Disease or Problem’ Status Using Molar Probing Depths: Model Development and Validation in NHANES Young to Middle-Aged Adults

Background/Objectives: A parsimonious multivariable model was engineered and externally validated using dental electronic health records to screen for a clinician-evaluated “gum disease or related problem” status. Designed for seamless electronic integration, a positive screening...

The paracrine Ephrin A4/BMP4 feed-forward loop sustains a tumor–CAF vicious cycle in osteosarcoma

Abstract Background Advanced osteosarcoma (OS) remains a clinical challenge due to its aggressive behavior and poor prognosis. Cancer-associated fibroblasts (CAFs) have been shown to contribute to tumor progression, but the tumor–CAF crosstalk in OS is still poorly defined. Eluci...

Early development of cortical networks is modulated by Family Nurture Intervention: a multicenter replication study

Abstract Background Prematurity is associated with a high risk of abnormal neurodevelopment, inflicting life-long neurocognitive consequences with major public health importance. This calls for early biomarkers of functional brain development to serve as indicators of the effect...

Repeated scoring with the adult appendicitis score improves the sensitivity and the specificity of appendicitis diagnosis in patients with early equivocal signs of appendicitis: a secondary analysis

Abstract Background The use of computed tomography at the early stage of acute appendicitis can lead to overdiagnosis and predispose patients unnecessarily to ionising radiation. Adult Appendicitis Score (AAS) can be used to select patients for imaging. Observation and re-scoring...

Students’ educational expectations: the role of school burnout and parental involvement

Adolescents’ educational expectations shape their futures. School burnout has been identified as affecting these expectations; however, research remains limited. Therefore, this study investigated the associations between school burnout (exhaustion and cynicism) and students’ edu...

Robust inference and correlates from genetic associations with personality

Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustne...

Transcriptional biomarkers of microplastic exposure in fish: a tissue-resolved scoping review

Microplastic exposure in fish has been increasingly assessed at the transcriptional level, yet findings remain dispersed across species, polymers, exposure routes, and tissues, limiting the identification of robust and transferable biomarkers. This scoping review examines which t...