University of Helsinki

Gut microbial metabolism of peanuts generates immunoregulatory metabolites

Background. Complementary feeding practices and timing are thought to significantly influence early life immune development, with the early introduction of allergenic foods being especially important for prevention of food allergy. We hypothesized that allergen-containing foods s...

Developmental divergence in gene regulation underlies trophic innovation in Lake Victoria cichlids

Abstract The role of developmental shifts in the emergence of ecological diversity during adaptive radiation remains largely uncharacterized. Here, we investigate the developmental gene regulatory landscape of trophic innovation in the rapid adaptive radiation of cichlid fishes f...

Evolution expresses the second law of thermodynamics in action

Abstract Evolution through natural selection has long been considered unique to biological systems, yet similar patterns emerge from physical, chemical, technological, economic and social processes. Skewed distributions, often near-lognormal, and sigmoidal courses, often with a p...

Remote sensing and deep learning for standing dead-tree detection and mapping: a review of advances, challenges, and future directions

Standing dead trees are visible indicators of tree mortality and an important transitional component linking forest disturbance to future lying deadwood, habitat availability, and carbon storage. As drought, insect outbreaks, pathogens, and climate extremes intensify tree mortali...

Plasma Protein Association with High Drug-Loaded Polymer Micelles: An Atomistic Molecular Dynamics Study

Abstract Polymeric micelles are widely studied drug delivery platforms whose interactions with plasma proteins influence in vivo performance. However, the combined effects of non-pEG hydrophilic coronas and high drug loading on protein adsorption remain poorly understood. We perf...

Snake kolmiovirus encodes a single form of delta antigen and shows no evidence of translation from ORF2

Hepatitis D virus (HDV) is a satellite virus that utilizes hepatitis B virus (HBV) as a helper for infectious particle formation. HDV was originally identified as a novel antigen in liver biopsies of HBV patients, and later studies showed the ‘delta’ antigen (DAg) to be the sole...

Assessing the Mining Effluent Impacts on Mercury Dynamics in Boreal Lakes

Abstract Mining wastewater and leakages into freshwater systems are a growing global concern, yet the impacts of bioleaching in open-pit mining on lake food webs and mercury dynamics remain understudied. This study examined three boreal lakes in eastern Finland: Jormasjärvi (prim...

Biotic and abiotic drivers of ecosystem functioning differ between a temperate and a tropical region

Any single ecosystem will provide many ecosystem functions. Yet, we lack large‐scale, systematic studies of how abiotic factors can directly or indirectly – via effects on biodiversity – drive ecosystem functioning. In this study, we assessed the impact of climate, landscape and...

Inequalities in sustainable ageing: functional mobility and depressive symptoms across migration subgroups among Russian-speaking migrants in Finland

Abstract Sustainable ageing depends on equitable opportunities to maintain physical, mental, and social well-being, yet older migrants are often treated as a homogeneous group. This study aimed to identify sociodemographic and migration-related subgroups among midlife and older R...

Sensitivity to ATR–CHK1 pathway inhibition in MDS/AML is enhanced by SRSF2 mutations and reduced by RUNX1 loss

Abstract SRSF2 mutations occur in 5–15% of acute myeloid leukemia (AML) and ~15% of myelodysplastic neoplasms (MDS), are enriched in elderly/secondary AML, and lack mutation-directed therapy. We aimed to identify vulnerabilities in MDS/AML with SRSF2 mutations. Ex vivo drug-sensi...

Characterization of SPP1 + macrophages and their correlation with resistance to neoadjuvant chemotherapy in colorectal cancer liver metastasis

Neoadjuvant chemotherapy (NAC) for colorectal cancer liver metastasis (CRLM) remains a major clinical challenge, with outcomes varying widely among patients, yet the mechanisms that drive therapeutic resistance remain incompletely understood. In this study, we integrated single‑c...

Resurvey of Boreal Earthworm Communities in Southern and Northern Finland

Boreal forests account for 11.5% of the Earth's land area, and, unlike oceanic and mediterranean forests, their cold winters typically represent the harshest season for earthworms. In Fennoscandia, these forests are subject to substantial global changes, notably climate change an...

NKCC1 coordinates SPAK-PP1 signalling to regulate KCC2 membrane stability and seizure susceptibility.

Chloride homeostasis, and thereby the efficacy of chloride-permeable GABAA receptor signaling, depends on the dynamic balance between NKCC1 (Na+-K+-2Cl- cotransporter 1) and KCC2 (K+-Cl- cotransporter 2), which respectively mediate chloride influx and extrusion to tightly control...

Surgical Indications for Type II Thyroplasty in Adductor Spasmodic Dysphonia: A Scoping Review

ABSTRACT Objective This scoping review mapped evidence on surgical eligibility criteria, efficacy, durability, and safety of Type II thyroplasty with titanium bridges for adductor spasmodic dysphonia to identify gaps and inconsistencies among studies and propose preliminary inter...

Quantifying Non‐Maxwellian Properties of Ion Populations During Reconnection at Earth's Magnetopause

Abstract We investigate ion velocity‐space features within the exhaust of magnetopause reconnection using a global hybrid‐Vlasov simulation. The Hermite transform and Gaussian Mixture Model (GMM) are applied to quantify the complexity of velocity‐space structures that arise durin...

Spring migration passage advances can be counteracted by range shifts

Long-term passage records of migrating birds from fixed observatories are widely used to infer spring migration phenology. Yet migrants recorded at a site need not represent a constant mixture of populations over time. Spring onset and optimal arrival occur later at higher latitu...

An Integrated Mobile Laboratory Workflow for Wastewater and Environmental Pathogen Surveillance: Performance Evaluation and Field Application in Sub-Saharan Africa

Abstract Mobile laboratories (MLs) offer a practical solution for decentralized wastewater and environmental surveillance in settings with limited laboratory infrastructure, cold-chain logistics, and trained personnel. However, field-deployable molecular workflows suitable for di...

Reproducibility of Colloidal Lignin Particle Preparation: An Interlaboratory Evaluation

Abstract The reproducibility of the preparation of colloidal lignin particles (CLPs) was evaluated through a coordinated interlaboratory study involving seven independent research groups from around the world. The objective was to assess the robustness of the anti-solvent precipi...

International Modified Delphi Consensus on Assessment and Management of Covert Brain Infarction

BackgroundCovert brain infarction (CBI) is a frequent incidental neuroradiological finding increasingly recognized as clinically relevant due to its association with stroke, cognitive decline, and other adverse outcomes. However, substantial uncertainty remains regarding its opti...

Gemma Jansen, Ann Olga Koloski-Ostrow, and Richard Neudecker, eds. Sixty-Six Toilets and Urinals in the Ancient City of Rome: Sanitary, Urbanistic, and Social Agency. Peeters Publishers, 2024. https://doi.org/10.2307/jj.24900056.

Gemma Jansen, Ann Olga Koloski-Ostrow, and Richard Neudecker, eds. Sixty-Six Toilets and Urinals in the Ancient City of Rome: Sanitary, Urbanistic, and Social Agency. Peeters Publishers, 2024. https://doi.org/10.2307/jj.24900056.