University of Helsinki

Surgical management of congenital extrahepatic portosystemic shunt in a pony foal

Summary A five‐month‐old Welsh pony filly was admitted to the Veterinary Teaching Hospital of the University of Helsinki due to neurological signs. Clinicopathological findings showed elevated ammonium and bile acid levels. Computed tomography revealed an aberrant vessel originat...

No evidence of increased gaming-related problems with long-term use of a video game therapeutic: Exploratory endpoint findings from a randomized controlled trial

Digital therapeutics for mental health often face low patient engagement, which limits their clinical impact. Interventions that deliver treatment using a video game medium may improve engagement and therapeutic efficacy, but the potential emergence of gaming-related problems rem...

Stakeholder views on recent changes to EU chemicals legislation – are they promoting green transformation or posing challenges for the pharmaceutical sector?

Recent changes to European Union's (EU) chemicals legislation aim to address chemicalisation of the environment and advance green transformation. Although pharmaceuticals are governed by sector-specific legislation and often exempt from certain provisions of chemicals legislation...

Insulin resistance in the 21st century: new takes on an old problem—2025 Diabetes, Diabetes Care, and Diabetologia Expert Forum

Insulin resistance is a hallmark of type 2 diabetes and several other metabolic diseases. However, efforts to improve insulin resistance are hindered by the biological complexity inherent to insulin action, as well as conceptual and methodological limitations to date. In Septembe...

Carbon source-dependent metabolic states govern redox homeostasis and cofactor biosynthesis in Propionibacterium freudenreichii

ABSTRACT Microbial adaptation to fluctuating nutrient and oxygen conditions requires coordinated regulation of the metabolic network to maintain redox homeostasis within physicochemical and energetic constraints. While oxygen-dependent responses in Propionibacterium freudenreichi...

Insulin Resistance in the 21st Century: New Takes on an Old Problem—2025 Diabetes , Diabetes Care , and Diabetologia Expert Forum

Insulin resistance is a hallmark of type 2 diabetes and several other metabolic diseases. However, efforts to improve insulin resistance are hindered by the biological complexity inherent to insulin action, as well as conceptual and methodological limitations to date. In Septembe...

Linking acute exposure to future risk: an omics-to-AOP new approach method for next-generation risk assessment in a human in vitro lung air–liquid interface model

New approach methodologies (NAMs) are transforming chemical safety assessment by shifting focus from apical toxicity endpoints toward mechanistic, human-relevant prediction of adverse outcomes. Here, we present a human lung air-liquid interface (ALI) alveolar epithelial model cou...

Prehospital whole blood transfusion versus component therapy—A scoping review

Abstract Background Whole blood has gained a foothold over component therapy in civilian emergency care, especially in emergency departments. In a prehospital setting, whole blood might be the logistically easier alternative compared to component therapy. However, most previous s...

Accelerating the market diffusion of bio-based innovations – Evidence from expert and business perspectives and policy strategies

Several policy strategies aim to promote the transition to a bioeconomy as a means to addressing the environmental issues of the prevailing mode of unsustainable production and consumption. Bio-based products, such as wood-based textile fibres and packaging solutions, are promote...

Could Failure Work as a Productive Force in Journalism Education? Ways of Thinking and Practising

Although Manu Kapur’s Productive Failure is a widely acknowledged pedagogical method in science, technology, engineering, and mathematics (STEM), its application in education for journalists remains largely underexplored. A bachelor’s-level course focused on entrepreneurial journ...

Personalized Treatment of Hemophilia: Matching Therapies to Patient Needs in a Rapidly Evolving Landscape

The therapeutic landscape of hemophilia, a rare inherited bleeding disorder, has rapidly evolved, introducing several novel modalities: extended half-life (EHL) coagulation factor concentrates, non-factor therapies, hemostasis-rebalancing agents, and gene therapy. These advances...

Researchers Inside the Prison Walls: Methodological and Ethical Reflections on Doing Research With Women in Prison

This article addresses the methodological and ethical challenges in doing research with women in marginalised position in the closed institutional setting of prison. It aims to show that along with formal access issues, it is crucial to acknowledge the positions and complex relat...

Age-based prognosis in oral tongue squamous cell carcinoma patients: A systematic review and meta-analysis

Abstract Background The prognostic significance of younger age in oral tongue squamous cell carcinoma (OTSCC) remains uncertain because age definitions, treatment strategies, outcome definitions, and adjustment methods vary substantially across studies. Objective To evaluate the...

The Mobile Hospital delivers outreach acute care to nursing homes: healthcare staff interviews

Abstract Background Nursing home residents often face unnecessary risks when visiting the emergency department (ED). Due to the limited rapid response capabilities of primary care and lack of equipment for acute illnesses, onsite specialized outreach units present a novel alterna...

Intraoperative monitoring of myocardial oxygenation during open-heart surgery: feasibility and initial performance

Abstract Myocardial protection during cardiopulmonary bypass relies on intermittent administrations of cardioplegia without continuous, tissue‑level feedback on myocardial oxygen supply and mitochondrial metabolic status. Extended near‑infrared spectroscopy (eNIRS) can enable rea...

Analysis code for: "Trends in the Incidence of Childhood Type 1 Diabetes After the COVID-19 Lockdown in Finland: An Observational Study"

Description This repository contains the analysis scripts, statistical code, and aggregated data supporting the manuscript: "Trends in the Incidence of Childhood Type 1 Diabetes After the COVID-19 Lockdown in Finland: An Observational Study". Overview The resources provided here...

Studying the Mirror Acceleration via Kinetic Simulations of Relativistic Plasma Turbulence

Abstract Efficient relativistic turbulent acceleration of particles is indicated by recent astrophysical observations. The acceleration mechanism due to temporal variations of magnetic field strengths (“Type II mechanism”) remains underexplored. The mirror acceleration has recent...

Analysis code for: "Trends in the Incidence of Childhood Type 1 Diabetes After the COVID-19 Lockdown in Finland: An Observational Study"

Description This repository contains the analysis scripts, statistical code, and aggregated data supporting the manuscript: "Trends in the Incidence of Childhood Type 1 Diabetes After the COVID-19 Lockdown in Finland: An Observational Study". Overview The resources provided here...

When Compliance Infrastructure Becomes a Security Object: Legal Reclassification between EU Supply Chain Due Diligence and China’s Order No. 834

Abstract Supply chain law increasingly renders global production governable through compliance infrastructure: supplier mapping, audit rights, traceability records, risk scoring, geolocation data, contractual monitoring, digital platforms and cross-border evidence flows. This art...

Understanding Newcomer Persistence in Social VR: A Case Study of VRChat

Newcomers are crucial for the growth of online communities, yet their successful integration into these spaces requires overcoming significant initial hurdles. Social Virtual Reality (VR) platforms are novel avenues that offer unprecedented online interaction experiences. Unlike...