University of Helsinki

Fast and Flexible Flow Decompositions in General Graphs via Dominators

Multi-assembly methods rely at their core on a flow decomposition problem, namely, decomposing a weighted graph into weighted paths or walks. However, most results over the past decade have focused on decompositions over directed acyclic graphs (DAGs). This limitation has led to...

The effect of hyperoxic environment on lung function and myopisation in an extended closed-circuit rebreather diving expedition

Introduction: Repetitive closed-circuit rebreather (CCR) dives subject the human body to a hyperoxic environment. Prolonged oxygen exposure can lead to lung abnormalities and myopic shift. The aim of this study was to analyse the effects of a 31-day period of repeated CCR dives o...

The state of diversity, equity, and inclusion in the cloud physics community

The Geosciences are amongst the least diverse research fields, where women and other underrepresented groups face systemic biases. This paper presents the state of diversity, equity, and inclusion (DEI) in the cloud-physics community, by combining a metadata analysis of 6987 clou...

Indices of obesity, malnutrition and inflammation are strong predictors of mortality in adults with type 2 diabetes: the FIELD study

Abstract Aims/hypothesis Metabolic risk in type 2 diabetes is not fully captured by standard clinical measures. Use of NMR-based metabolomic indices may enhance risk prediction, but their role in individuals with type 2 diabetes is unresolved. Methods We analysed data from 9550 a...

LazypipeX: customizable virome analysis pipeline enabling fast and sensitive virus discovery from NGS data

Abstract Metagenomic next-generation sequencing (mNGS) is pivotal for detecting known and novel viruses, however, its efficacy depends on applied bioinformatics pipelines. We present Lazypipe Extended (LazypipeX), an mNGS pipeline employing modular “annotation strategies” to opti...

Persistence of Cyanobacterial Blooms Under Low-power Ultrasonication in a Deep, Mesotrophic, Stratifying Lake

Cyanobacteria are a natural component of aquatic ecosystems. However, when proliferating excessively, they can degrade water quality and restrict recreational use by forming harmful algal blooms (HABs). Consequently, there is growing interest in developing rapid HAB management te...

Interplay between fibroblast growth factor 9 (FGF9) and CD44 underlies 46,XY disorders of sex development in Kruppel‐like factor 1 (KLF‐1)‐E325K‐associated congenital dyserythropoietic anaemia (CDA‐IV)

Summary A heterozygous Kruppel‐like factor 1 (KLF1) E325K mutation causes a severe form of congenital dyserythropoietic anaemia (CDA), designated CDA‐IV (Online Mendelian Inheritence in Man, OMIM 613673), a rare disease with only 15 cases known. In addition to haemolytic anaemia,...

Emerging food- and waterborne pathogen Arcobacter in wastewater: diversity and antibiotic resistance

ABSTRACT Arcobacter spp. are emerging food- and waterborne pathogens frequently detected in wastewater. Despite their high abundance in wastewater, Arcobacter diversity, antibiotic resistance, and genomic traits remain poorly characterized. To address these knowledge gaps, we con...

Distributional implications of selection into heating-system retrofit subsidies

As the shift away from fossil fuel-based heating systems has become a political priority in many countries, subsidies for energy renovation measures have emerged as popular policy tools to support an equitable energy transition. In this paper, we use high-quality administrative d...

Eco-evolutionary dynamics and environmental detoxification jointly shape bacterial community response to antibiotic perturbation

Microbial communities frequently encounter recurrent antibiotic disturbance, yet how ecological, evolutionary, and environmental processes jointly shape community responses remains unresolved. Here, we use priming to describe the history-dependent effect whereby prior exposure al...

A Robotics and Coding Project-Based Learning Module: Creative and Critical Thinking in Primary Classrooms

Creative and critical thinking are emphasized in curriculum policy, yet little is known about how they appear together in primary project-based robotics and coding. This video-based study examined observable modes of creative and critical thinking, their phase-specific variation,...

A genetic and historical perspective on the origins of keratitis fugax hereditaria

Abstract Purpose To investigate the genetic and genealogical background of keratitis fugax hereditaria (KFH), a periodic corneal disease caused by the heterozygous pathogenic variant c.61G>C in the NLRP3 gene. KFH is characterized by recurrent unilateral autoinflammatory attacks...

Effects of Botulinum Toxin Injection on Masticatory Muscle Activity in Sleep Bruxism: A Systematic Review and Meta-Analysis

Background/Objectives: Bruxism, encompassing both awake (AB) and sleep bruxism (SB), is a prevalent condition associated with involuntary jaw muscle activity, leading to tooth wear and muscle hypertrophy. Botulinum toxin type A (BoNT-A) has emerged as a potential treatment by red...

Facts and values in (de)growth economics

Abstract The role of values in scientific contexts has become a large topic of discussion in philosophy and elsewhere. Climate economics, like many sustainability sciences, experiences stark divergences between different scientific perspectives on what the future will look like a...

dicast: a machine learning method for accurate structural variant detection from short-read sequencing data

Abstract Structural variants are a common cause of human diseases, but their detection from short-read sequencing remains challenging, despite being the technology underlying most clinical workflows. We present dicast , a machine-learning method that scores SV calls from short-re...

Collective memories, emotional analogues and war: How the Winter War shaped the Finnish public understanding of the War in Ukraine

Culturally specific collective memories often give rise to potent and emotional historical analogues, used to mobilize people and to understand new situations. This article examines such emotional analogues through the still dominant but highly selective Finnish collective memory...

Explaining evidential discordance

Abstract Evidential discordance, or the situation where scientific evidence supports contrary hypotheses, claims or theories about a given phenomenon, is common in scientific inquiry (Franklin, 2002; Boyd, 2018; Stegenga, 2009, 2012). Although in many ways useful for scientific p...

Holocene summer and winter temperature trends and excursions in East-Central Europe from Carpathian pollen records

This study reconstructs summer and winter temperatures for East-Central Europe (ECE) over the last 12 ka using pollen records from five mid-altitude sites in the Carpathian Mountains. Seasonal reconstructions were combined into composite records and statistically evaluated to ide...

TMD factorization in diffractive heavy quark production in photon-nucleus collisions

A bstract Using the Colour Glass Condensate effective theory, we study the diffractive production of a massive quark-antiquark pair accompanied by a gluon in coherent photon-nucleus collisions at high energy. This partonic configuration provides the leading twist contribution to...

Housing tenure, climate resilience, and ecological segregation

A key challenge to ensuring no one is left behind in the green transition lies in the persistent segregation of urban populations and the unequal distribution of environmental costs and benefits. Residential segregation has long reinforced socioeconomic and racialized disparities...