University of Freiburg

Struggling for resonance: Mediopassive interaction in a long-term treatment of severe personality disorder.

Although clinicians often report significant emotional challenges in psychotherapy for personality disorders, we still know relatively little about how these difficulties are enacted and reorganized in moment-to-moment patient-therapist interaction. We examine whether interaction...

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E6...

Climatological assessment of the summer half-year (Apr-Sep) 2026 at Hartheim Forest Research Station (DE-Har)

Summary: Summer half year 2026 was to-date the warmest, sunniest and direst summer-half year since continuous measurements began at the Hartheim Forest Research Station (ICOS DE-Har) in 1978. Average air temperature during summer half-year 2026 was 18.4° which is +2.5K above the...

Climatological assessment of the summer half-year (Apr-Sep) 2026 at Hartheim Forest Research Station (DE-Har)

Summary: Summer half year 2026 was to-date the warmest, sunniest and direst summer-half year since continuous measurements began at the Hartheim Forest Research Station (ICOS DE-Har) in 1978. Average air temperature during summer half-year 2026 was 18.4° which is +2.5K above the...

A wastewater balance reveals unexpectedly high TFA input from human water use

Abstract Trifluoroacetate (TFA) is a member of the PFAS group and shares their persistence. Its very small molecular size and anionic character makes it, in contrast to many other PFAS, highly water-soluble and mobile in the aquatic environment. Wastewater shows elevated TFA conc...

Estimating value-at-risk: LSTM vs. GARCH

Abstract Estimating value-at-risk on time series data with potentially heteroskedastic dynamics is a highly challenging task. In practical applications, one often faces limited sample sizes in combination with a high degree of non-linearity, which poses difficulties for both clas...

The WoKaS-Iso database: workflow for a global compilation of oxygen-18 and deuterium records in karst springs and cave drip water for enhanced understanding of karst systems

For analysing karst hydrogeological systems, observations of karst springs and cave drips are considered indispensable. In addition to hydrometric observations, knowing the oxygen and hydrogen stable isotope ratios has improved the understanding of vadose zone and aquifer dynamic...

A globally convergent method for computing B-stationary points of mathematical programs with equilibrium constraints

Abstract This paper introduces a computationally efficient method that converges globally to B-stationary points of mathematical programs with equilibrium constraints (MPECs). B-stationarity is necessary for optimality and means that no feasible first-order direction can improve...

Cobalt‐Catalyzed [2σ+2π] Cycloaddition via Site‐Selective Capture of Bicyclobutane Diradical

ABSTRACT Strained bicyclo[1.1.0]butanes (BCBs) have emerged as versatile precursors for accessing highly reactive intermediates, enabling unconventional bond constructions through strain‐release pathways. Herein, we report a cobalt(II)‐catalyzed strategy that combines thermal act...

Feasibility and performance of eye movement perimetry for glaucoma triage in Tanzania: A prospective cross-sectional study in a real-world setting

Triaging access to glaucoma diagnostics could allow patients to receive earlier care to slow disease progression. There is a particular need in lower-resource settings where the cost and lack of portability of standard automated perimetry (SAP) restrict access. Eye movement perim...

Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network

Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially)...

Representation Theorems for Convex Expectations and Semigroups on Path Space

The objective of this paper is to investigate the connection between penalty functions from stochastic optimal control, convex semigroups from analysis, and convex expectations from probability theory. Our main result provides a one-to-one relation between these objects. As an ap...

In situ visualization of autophagy reveals the presence of vesicles at the expanding phagophore rim

The autophagy core machinery mediates the enclosure of cytosolic cargo destined for degradation in the lysosome. The Atg9-Atg2-Atg18 complex coordinates phagophore expansion via directed lipid transfer until closure of the phagophore rim. Using an Atg2 variant (Atg2-PM4) as a mod...

A Statistical Perspective on Transformers for Small Longitudinal Cohort Data

ABSTRACT Modeling of longitudinal cohort data typically involves complex temporal dependencies between multiple variables. There, the transformer architecture, which has been highly successful in language and vision applications, allows us to account for the fact that the most re...

Balancing Risk and Reward: Red Fox Exploitation of Kill Sites in a Wolf‐Occupied Landscape

ABSTRACT In carnivore guilds, apex predators and mesocarnivores may interact through mechanisms ranging from antagonism to facilitation. The recent recolonization of the gray wolf Canis lupus in the Alps offers a valuable opportunity to investigate how wolf kill sites influence m...

A predictive coding framework for safe and versatile control of supernumerary robotic limbs

Supernumerary robotic limbs (SLs) have the potential to extend human sensorimotor capabilities by increasing effective degrees of freedom. However, current systems are designed for a single task and cannot flexibly coordinate with natural limbs (NLs). Here we propose a hierarchic...

Lysosomal signaling pathways influence heart rhythm, and regulate atrial function

AIMS: In the heart, endogenous nicotinic acid adenine dinucleotide phosphate (NAADP) triggers lysosomal calcium (Ca2+) release to augment sarcoplasmic reticulum (SR) Ca2+ sequestration, producing larger Ca2+ transients. However, the role of lysosomal Ca2+ signals in pacemaker act...

Exploiting structural repetition for synthetic training data generation in LiDAR point cloud segmentation

Maintaining aging tunnel infrastructure requires inspection supported by digital tools such as Building Information Models (BIMs). Scan-to-BIM methods based on deep learning automate BIM creation from Light Detection and Ranging (LiDAR) point clouds. However, supervised training...

The road ahead: How the future of learning is shaped through individual differences

The future of learning is often framed through technological change. Here, we show that these developments do not replace, but emphasize, long-standing questions in educational psychology, concerning why learners benefit differently from the same opportunities, how learning envir...

Not speaking my language: playback experiments reveal early-orphaned human-reared adult cheetahs lack interest in species-specific vocalizations

Abstract Early adult models, particularly the mother, play an essential role in tuning perception to build the multimodal representation of species-specific social signals, especially in mammals. Therefore, early maternal loss adversely impacts social integration in mammals. More...