University of Freiburg

Insights into the development and key factors of five European governance innovations for forest ecosystem service provision

Climate change and biodiversity loss necessitate the forestry sector to adapt its management practices to provide forest ecosystem services (FES) sustainably. However, there is a limited understanding of influences that foster novel governance approaches in forest management syst...

Decoupling of emigration timing and skill acquisition in a saturated population of golden eagles

Abstract Many animals must gain independence from parental care by acquiring skills necessary for survival. Thus, the rate of skill acquisition can predict when parental care ends and animals emigrate. However, young animals sometimes acquire adult-like skills long before they em...

Combination therapy of sutimlimab and rituximab can lead to stable remission in autoimmune hemolytic anemia: a case series

Abstract Autoimmune hemolytic anemia (AIHA) is associated with a significant impairment of quality of life for affected patients and can lead to life-threating hemolytic crises. Complement-mediated destruction of antibody-opsonized erythrocytes is a central pathomechanism in many...

Elevated IL-10 is Linked With the Expansion of T-bethighCD21low B Cells in Patients With Common Variable Immunodeficiency

Abstract Common variable immunodeficiency (CVID) is frequently complicated by autoimmune and inflammatory manifestations associated with profound immune dysregulation (CVIDc), including expansion of T-bet high CD21 low B cells (CD21 low B cells). Elevated serum IL-10 levels have...

AngleCam V2: Predicting leaf inclination angles across taxa from daytime and nighttime photos

Abstract Understanding how plants capture light and maintain their energy balance is crucial for predicting how ecosystems respond to environmental changes. By monitoring leaf inclination angle distributions (LIADs), we can gain insights into plant behaviour that directly influen...

Reduced IP6K levels impair life-cycle transitions and intracellular development of Trypanosoma cruzi within human cardiomyocytes

Trypanosoma cruzi is the etiological agent of Chagas disease (CD). During its life cycle, T. cruzi undergoes several key differentiation processes that are essential for its survival. The precise mechanisms that regulate these processes remain elusive, and any interference in thi...

Outcome after cataract surgery with IOL implantation in adolescents and adults with juvenile idiopathic arthritis (JIA) associated or ANA-positive anterior uveitis

Purpose Cataract surgery in patients with chronic anterior uveitis may be associated with increased risk for complications and poor outcomes. This study analyses visual outcome, uveitis course and complications after cataract surgery with intraocular lens (IOL) implantation in ad...

The parameter estimation tables (PEtab) format version 2

Abstract Parameter estimation is a central task in data-driven computational modeling, and a clear, unambiguous, and commonly understood specification of parameter estimation problems is essential for reproducibility and interoperability. PEtab provides a standardized framework f...

Motivation to Change, Therapeutic Alliance and Outcome—A Complex Interaction in Patients With Anorexia Nervosa

ABSTRACT Objective The role of the therapeutic alliance (TA) in treatment outcomes of anorexia nervosa (AN) appears to be less substantial than in other disorders. However, the therapeutic process is a complex trajectory with many variables influencing each other. Hence, investig...

S -Adenosyl- l -homocysteine Hydrolase Side Reactivity Enables Biocatalytic Access to 4′,5′-Dehydro Nucleosides as Nucleoside Drug Precursors

Abstract S-Adenosyl-l-homocysteine hydrolase (SAHH) reversibly cleaves S-adenosyl-l-homocysteine (SAH) into adenosine and l-homocysteine, regulating the cellular potential to perform S-adenosyl-l-methionine (SAM)-dependent methylation of DNA, RNA, proteins, and small molecules. A...

Introducing GalaxyR: an easy-to-use R implementation of the Galaxy API

Abstract Background Standardisation, accessibility, and reproducibility remain persistent challenges in data‑intensive scientific research. The Galaxy platform addresses these issues by providing a web-based environment for executing, sharing, and publishing computational workflo...

Predicting rainfed and irrigated yield responses under drought with soil-hydrological modelling and variety trials for economic evaluation

Abstract Agricultural droughts in many humid regions such as Southern Germany are projected to become more frequent and severe, leading to a substantial rise in irrigation demand to secure crop production. As a result, irrigation is becoming an increasingly important factor in ag...

Alkaline hydrolysis of electrospun PAN/h-BN composite nanofibres: Structural and chemical baseline for ionic electroactive polymer applications

Electrospun polyacrylonitrile (PAN) / hexagonal boron nitride (h-BN) composite nanofibre membranes (h-BN: 0–40 wt%) were hydrolyzed with equimolar (2.0 M) NaOH and KOH, and the resulting fifteen compositions were characterized by SEM, ATR-FTIR, XRD, n -butanol porosimetry, and gr...

Scalable Synthesisof a Masked Thiophenol as an Air-Stable,Odorless Intermediate to the Aurora Kinase Inhibitor Tozasertib (VX-680)

Abstract The use of thiophenols on process scales is fraught with challenges relating to their toxicity, malodor, and air sensitivity. We previously demonstrated that the Ni-catalyzed C–S coupling of aryl iodides and thiourea provides a discovery-scale route to S-aryl isothiouron...

Treatment with Cistus incanus and Rosmarinus officinalis reduces inflammatory processes in an in vitro virus mimicry approach

Acute respiratory viral diseases caused by single-stranded RNA (ssRNA) viruses like influenza A infection occur frequently in all age groups, with significant impact on morbidity and mortality worldwide. The severity and burden of the disease is tightly connected to host inflamma...

Queen loss fails to elicit physiological and transcriptional responses in workers of the invasive garden ant Lasius neglectus.

Colonies of insects with morphologically distinct castes have been called superorganisms because the function of their queens and workers is analogous to the germline and soma in metazoan bodies. In the case of formicoid ants, workers typically have lost the sperm storage organ,...

DECIDER-2: Prospective randomized multicenter phase III trial of decitabine and venetoclax administered in combination with all-trans retinoic acid or placebo in patients with acute myeloid leukemia who are ineligible for induction chemotherapy

Abstract Background Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of the combination of venetoclax (VEN) with azacitidine (AZA) or decitabine (DAC) in the European Union in 2021 for the treatment of patients wit...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

Electrochemical in vivo oxygen sensing on cochlear implants

Abstract Cochlear implants (CIs) are the most frequently implanted neuroprostheses. Despite the clinical success of CIs, the processes actually occurring at the electrodes post-implantation remain unknown, and the majority of research is limited to endpoint analyses. Electrochemi...

Using a digital health tool to strengthen community engagement in arboviral disease prevention: an implementation study in Colombia

Abstract Background Arboviral diseases remain major public health problems in Colombia. Mobile applications such as WhatsApp are increasingly being used to support health interventions by improving community engagement and preventive practices. Given its widespread use in Colombi...