University of Freiburg

Frameworks to identify research gaps, frame research needs, and derive research priorities from evidence syntheses:a scoping review

Objectives To identify and describe frameworks for systematically identifying research gaps from evidence syntheses, framing research needs, and establishing priorities, with emphasis on their use of GRADE (Grading of Recommendations Assessment, Development and Evaluation) certai...

A single-amino-acid cleavage controls global mitochondrial complex integrity

Abstract Mitochondrial proteostasis depends on precise N-terminal processing of imported precursor proteins. Defects in this maturation step are implicated in disease, yet the functional impact in humans remains unclear. Here we show that the intermediate cleaving peptidase ICP55...

Tricuspid-Valve Intervention in Heart Failure

BackgroundThe effect of transcatheter tricuspid-valve repair on clinical outcomes, including death and hospitalization for heart failure, in patients with severe tricuspid regurgitation remains uncertain. MethodsWe randomly assigned patients with symptomatic severe tricuspid regu...

Design of a Multistable Finger Prosthesis with Programmable Metamaterials

Shape change, as well as the ability to hold specific deformation, is a main requirement for finger prostheses. Currently, these functionalities are realized by screwed hinges with latching elements. To avoid the assembly process and increase the sustainability a non-assembly, 3D...

IoT-based monitoring workflow for continuous analysis of apple ripening delay and maturation patterns under agrivoltaics

Abstract Agrivoltaic systems, combining solar energy generation with agricultural activities, offer a sustainable approach to maximising land efficiency. However, these systems can present challenges, such as potential shading effects that may impact fruit quality or crop yields....

Between myopathy and mortality: Challenges in the diagnosis of PLOD1 -related kyphoscoliotic Ehlers-Danlos syndrome

Objective PLOD1-related kyphoscoliotic Ehlers-Danlos syndrome (kEDS) is a rare autosomal recessive connective tissue disorder characterized by generalized joint laxity, severe congenital hypotonia, progressive kyphoscoliosis, hyperextensible and easily bruised skin, ocular abnorm...

Volumetric reference data of the orbit: a deep learning MRI analysis in the German national cohort

Abstract Manual segmentation of orbital magnetic resonance imaging (MRI) is labor-intensive, hindering large-scale morphometric studies. To overcome this, we developed a fully automated deep learning pipeline to segment orbital MRIs and establish age- and sex-stratified normative...

Impact of combined Hydrus Microstent implantation and cataract surgery on diurnal intraocular pressure range: a longitudinal, retrospective study

Abstract Purpose To evaluate the impact of combined Hydrus Microstent implantation and cataract surgery on the 24-hour intraocular pressure (IOP) range in patients with open-angle glaucoma. Patients and methods This retrospective, single-center study included 125 consecutive eyes...

A biomechanical comparison of closed-reduction osteosynthesis techniques for fractures of the ulnar styloid

BACKGROUND: Ulnar styloid fractures (USF) are frequently underestimated and can contribute to clinically relevant wrist instability and impaired functional outcomes. Several osteosynthesis techniques are available for the treatment of unstable USF. This study aims to compare the...

Elucidating a potential role of the infant gut microbiome on L-tyrosine bioavailability in phenylketonuria using whole-body metabolic modelling

Phenylketonuria (PKU) is an inherited metabolic disorder caused by phenylalanine hydroxylase (PAH) deficiency, leading to elevated L-phenylalanine and severe neurological damage if untreated. While phenylalanine-based biomarkers are diagnostic and phenylalanine levels correlate w...

MoCaNLO: a Monte Carlo integrator for NLO calculations

Abstract We present the Monte Carlo integration code MoCaNLO, which computes cross sections and distributions for processes at high-energy colliders like the LHC at leading and next-to-leading order (NLO) in the strong and electroweak couplings. It relies on the Recola package fo...

A Cournot–Nash model for a coupled hydrogen and electricity market

Abstract We present a novel model of a coupled hydrogen and electricity market on the intraday time scale, where hydrogen gas is used as a storage device for the electric grid. Electricity is produced by renewable energy sources or by extracting hydrogen from a pipeline that is s...

Insights into the development and key factors of five European governance innovations for forest ecosystem service provision

Climate change and biodiversity loss necessitate the forestry sector to adapt its management practices to provide forest ecosystem services (FES) sustainably. However, there is a limited understanding of influences that foster novel governance approaches in forest management syst...

Decoupling of emigration timing and skill acquisition in a saturated population of golden eagles

Abstract Many animals must gain independence from parental care by acquiring skills necessary for survival. Thus, the rate of skill acquisition can predict when parental care ends and animals emigrate. However, young animals sometimes acquire adult-like skills long before they em...

Combination therapy of sutimlimab and rituximab can lead to stable remission in autoimmune hemolytic anemia: a case series

Abstract Autoimmune hemolytic anemia (AIHA) is associated with a significant impairment of quality of life for affected patients and can lead to life-threating hemolytic crises. Complement-mediated destruction of antibody-opsonized erythrocytes is a central pathomechanism in many...

Elevated IL-10 is Linked With the Expansion of T-bethighCD21low B Cells in Patients With Common Variable Immunodeficiency

Abstract Common variable immunodeficiency (CVID) is frequently complicated by autoimmune and inflammatory manifestations associated with profound immune dysregulation (CVIDc), including expansion of T-bet high CD21 low B cells (CD21 low B cells). Elevated serum IL-10 levels have...

Reduced IP6K levels impair life-cycle transitions and intracellular development of Trypanosoma cruzi within human cardiomyocytes

Trypanosoma cruzi is the etiological agent of Chagas disease (CD). During its life cycle, T. cruzi undergoes several key differentiation processes that are essential for its survival. The precise mechanisms that regulate these processes remain elusive, and any interference in thi...

AngleCam V2: Predicting leaf inclination angles across taxa from daytime and nighttime photos

Abstract Understanding how plants capture light and maintain their energy balance is crucial for predicting how ecosystems respond to environmental changes. By monitoring leaf inclination angle distributions (LIADs), we can gain insights into plant behaviour that directly influen...

The parameter estimation tables (PEtab) format version 2

Abstract Parameter estimation is a central task in data-driven computational modeling, and a clear, unambiguous, and commonly understood specification of parameter estimation problems is essential for reproducibility and interoperability. PEtab provides a standardized framework f...

Outcome after cataract surgery with IOL implantation in adolescents and adults with juvenile idiopathic arthritis (JIA) associated or ANA-positive anterior uveitis

Purpose Cataract surgery in patients with chronic anterior uveitis may be associated with increased risk for complications and poor outcomes. This study analyses visual outcome, uveitis course and complications after cataract surgery with intraocular lens (IOL) implantation in ad...